CAS: 66376-36-1; (4-Amino-1-Hydroxybutane-1,1-Diyl)Diphosphonic Acid

上下游产品

4-amino-n-butyric acid tetramethyl (4-phthalimido-1-hydroxybutylidene)bisphosphonate 4-phthalimidobutyryl chloride 2-pyrrolidinon sodium alendronate

Sodium Alendronate置于盐酸,乙醇,水体系中,化学反应 2.0H,反应生成 阿仑膦酸
参考文献: Antiresorptive Mutual Salt Of Raloxifene And Bisphosphonic Acid[fr] Sels Antiresorbants De Raloxifene Et D'Acide Biphosphonique
标题: Antiresorptive Mutual Salt Of Raloxifene And Bisphosphonic Acid[fr] Sels Antiresorbants De Raloxifene Et D'Acide Biphosphonique
摘要:来自拉洛西芬和双磷酸盐的相互盐表现出两种成分之间意想不到的协同效应,以增强骨密度(bmd),控制血钙密度并降低血清胆固醇水平.

专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:WO-2025078505-A1
优先权日:2023-10-13
标 题 :One pot gmp scalable production method for the synthesis of dextran-guanidine-bisphosphonate conjugate
发明人：HOLMBERG ANDERS R
权利人:DEXTECH MEDICAL AB
摘要:The disclosure relates to a large scale GMP synthesis of a modified dextran conjugate, and more particularly to a dextran-guanidine-bisphosphonate conjugate wherein the bisphosphonate is an alendronate group. The disclosure relates to a large scale GMP synthesis that produces high purity, pharmaceutical grade dextran-guanidine-bisphosphonate conjugate. The present disclosure further concerns the use of said dextran-guanidine-bisphosphonate conjugate in medicines treating tumors.

专利号:US-12146136-B2
优先权日:2020-03-26
标题:Synthesis of modified oligonucleotides with increased stability
发明人：KHVOROVA ANASTASIA; ROUX LOÃ?C MAURICE RENÉ JEAN; YAMADA KEN
权利人:UNIV MASSACHUSETTS
摘要:This disclosure relates to the synthesis of novel modified oligonucleotides. The synthesis of novel phosphoramidites are also provided.

专利号:US-8178712-B2
优先权日:2006-06-23
标 题:Process for the synthesis of Ibandronate sodium
发明人：RAO DHARAMARAJ RAMCHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI GANPATI
权利人:RAO DHARAMARAJ RAMCHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI GANPATI; CIPLA LTD
摘要:The present invention relates to an improved process for the synthesis of Ibandronate sodium of formula (I). The present invention also provides novel processes for the synthesis of 3-[N-(methylpentyl)amino]propionic acid (III).

专利号:US-2024009660-A1
优先权日:2022-07-05
标题 :Methods for synthesis of hierarchically ordered crystalline microporous materials with long-range mesoporous order
发明人：PARSAPUR RAJESH KUMAR; HODGKINS ROBERT PETER; KOSEOGLU OMER REFA; HUANG KUO-WEI; SEDJERARI ANISSA BENDJERIOU
权利人:SAUDI ARABIAN OIL CO; UNIV KING ABDULLAH SCI & TECH
摘要:Methods for synthesis of hierarchically ordered zeolites and zeolite-type materials are provided. Synthesized hierarchically ordered zeolites and zeolite-type materials formed according to the methods herein possess a high-degree of well-defined long-range mesoporous ordering. The methods include base-mediated reassembly, by dissolution of the parent material to the level of oligomeric structural building units of the parent material, and minimizing or avoiding amorphization/structural collapse. The dissolution and self-assembly is comprehensively controlled to produce hierarchically ordered zeolites and zeolite-type materials according to the methods herein.

专利号:US-2024010662-A1
优先权日:2022-07-05
标题 :Methods for synthesis of hierarchically ordered crystalline microporous materials with long-range mesoporous order
发明人：PARSAPUR RAJESH KUMAR; HODGKINS ROBERT P; KOSEOGLU OMER REFA; HUANG KUO-WEI; SEDJERARI ANISSA BENDJERIOU
权利人:SAUDI ARABIAN OIL CO; UNIV KING ABDULLAH SCI & TECH
摘要:Methods for synthesis of hierarchically ordered zeolites and zeolite-type materials are provided. Synthesized hierarchically ordered zeolites and zeolite-type materials formed according to the methods herein possess a high-degree of well-defined long-range mesoporous ordering. The methods include base-mediated reassembly, by dissolution of the parent material to the level of oligomeric structural building units of the parent material, and minimizing or avoiding amorphization/structural collapse. The dissolution and self-assembly is comprehensively controlled to produce hierarchically ordered zeolites and zeolite-type materials according to the methods herein.