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Succinylsulfathiazole CAS Registry Number: 116-43-8 琥珀磺胺噻唑

CAS Name: 4-Oxo-4-[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]butanoic acid
Additional Names: 4'-(2-thiazolylsulfamoyl)succinanilic acid; p-2-thiazolylsulfamylsuccinanilic acid; 2-(N4-succinylsulfanilamido)thiazole
Trademarks: Sulfasuxidine (Merck Co.)
Percent Composition: C 43.93%, H 3.69%, N 11.82%, O 22.51%, S 18.04%

📌 参考资料/链接：
Literature References: Prepd by refluxing sulfathiazole with a slight excess of succinic anhydride in alcohol: Moore, Miller, J. Am. Chem. Soc. 64, 1572 (1942); US 2324013; US 2324014 (both 1943); by refluxing p-succinimidobenzenesulfonyl chloride with 2-aminothiazole in benzene: GB 578004 (1946). Toxicology: A. D. Welch et al., J. Pharmacol. Exp. Ther. 75, 231 (1942).

📄 详细内容

Derivative Type: Monohydrate
Properties: Crystals with unclear mp. Has been reported as mp 184-186°; also reported as mp 192-195°. Emits pungent fumes on heating to mp. One gram dissolves in about 4800 ml water. Soluble in solns of alkali hydroxides and in solns of sodium bicarbonate with the evolution of carbon dioxide; sparingly sol in alcohol and in acetone. Insol in chloroform and ether. LD50 i.p. in mice: ~5.7 g/kg (Welch).
Melting point: mp 184-186°; mp 192-195°
Toxicity data: LD50 i.p. in mice: ~5.7 g/kg (Welch)
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial, esp in enteric infections.
Keywords: Antibacterial (Synthetic); Sulfonamides.
产品链接: 116-43-8››

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