CAS: 116-43-8; 4-Oxo-4-((4-(N-(Thiazol-2-yl)Sulfamoyl)Phenyl)Amino)Butanoic Acid

该化合物是具有抗菌特性的磺酰胺衍生物,主要用作肠道乳房化剂,其主要优势在于其有限的系统吸收,允许其在肠胃道内就地行动,同时尽量减少系统性副作用;该化合物对一系列抗克菌阳性和克菌阴性细菌有效,有助于治疗肠道感染;其氨基混合物会提高溶性,并减少肾毒性,而与其他磺酰胺相比.

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ECHA物质ECHA物质C&L通报REACH预注册

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CAS号108-30-5 丁二酸酐 | CAS号72-14-0 磺胺噻唑 | CAS号36340-57-5 N,N-succinyl-su... | CAS号96-50-4 2-氨基噻唑 | CAS号5694-39-3 N-(4-chlorosulf... | CAS号110-15-6 琥珀酸； 丁二酸

合成工艺路线路线简述

    📜N,N-Succinyl-Sulfanilic Acid Thiazol-2-Ylamide置于sodium Hydroxide体系中,化学反应生成琥珀酰磺胺噻唑
    参考文献:Dicarboxylic Acid Derivatives Of Sulfonamides1
    标题:Dicarboxylic Acid Derivatives Of Sulfonamides1
    摘要:
    Doi:10.1021/ja01259A023

    海关参考信息

    专利信息


    专利号:US-6613942-B1
    优先权日:1997-07-01
    标题 :Glucagon antagonists/inverse agonists
    发明人：LING ANTHONY; GREGOR VLAD; GONZALEZ JAVIER; HONG YUFENG; KIEL DAN; KUKI ATSUO; SHI SHENGHUA; NAERUM LARS; MADSEN PETER; SAMS CHRISTIAN; LAU JESPER; PLEWE MICHAEL BRUNO; FENG JUN; TENG MIN; JOHNSON MICHAEL DAVID; TESTON KIMBERLY ANN; SIDELMANN ULLA GROVE; KNUDSEN LOTTE BJERRE
    权利人:NOVO NORDISK AS
    摘要:Non-peptide compounds comprising a central hydrazide motif and methods for the synthesis thereof are disclosed. The compounds act to antagonize the action of the glucagon peptide hormone.

    专利号:CN-101208345-B
    优先权日:2005-05-25
    标 题 :(S) -N-methylnaltrexone, method of synthesis and pharmaceutical use thereof

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Maternal gut and fetal brain connection: Increased anxiety and reduced social interactions in Wistar rat offspring following peri conceptional antibiotic exposure Stéphanie Degroote, Darel J. Hunting, Andrea A. Baccarelli, Larissa Takser Prog Neuropsychopharmacol Biol Psychiatry. Author manuscript; available in PMC 2019 Jun 20.Published in final edited form as: Prog Neuropsychopharmacol Biol Psychiatry. 2016 Nov 3;
    71: 76–82. Published online 2016 Jun 21. doi: 10.1016/j.pnpbp.2016.06.010 Clapper, Ikuya T. Kurita J Bacteriol. 1948 Feb; 55(2): 277–284. 2019 Jan; 3(1): nzy070. Published online 2018 Oct 3. doi: 10.1093/cdn/nzy070 PMCID: PMC6324351

    合成参考文献


    摘要:CRC Handbook of Antibiotic Compounds, Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980, 7(151), 1981
    摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
    摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 1985. Acute oral toxicity and repellency of 933 chemicals to house and deer mice. Archives of Environmental Contamination and Toxicology 14:111-129.
    摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 2004. Toxicity, Repellency of Phytotoxicity of 979 Chemicals to Birds, Mammals and Plants. Research Report No. 04-01. National Wildlife Research Center, Fort Collins, Colorado. 118 pp.
    参考文献:10.1007/bf02784087
    摘要:Uthus EO, Poellot RA. Dietary folate affects the response of rats to nickel deprivation. Biol Trace Elem Res. 1996 Apr;52(1):23–35. doi: 10.1007/bf02784087.
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