Derivative Type: Calcium salt trihydrate
CAS Registry Number: 344423-98-9; 134523-03-8 (anhydrous)Trademarks: Lipitor (Parke-Davis); Sortis (Pfizer); Torvast (Pfizer); Totalip (Guidotti)
Percent Composition: C 65.55%, H 6.17%, Ca 3.31%, F 3.14%, N 4.63%, O 17.20%
Properties: White to off-white crystalline powder. [a]D -7.4° (c = 1 in DMSO). Freely sol in methanol; slightly sol in ethanol; very slightly sol in acetonitrile, distilled water, phosphate buffer (pH 7.4). Insol in aq solns of pH 4 and below.
Optical Rotation: [a]D -7.4° (c = 1 in DMSO)
Derivative Type: Sodium salt
CAS Registry Number: 134523-01-6
Percent Composition: C 68.26%, H 5.90%, F 3.27%, N 4.82%, Na 3.96%, O 13.78%
Properties: pKa 4.46. Soly in water (30°): 20.4 mg/ml (pH 2.1); 1.23 mg/ml (pH 6.0).
pKa: pKa 4.46
Derivative Type: Lactone
CAS Registry Number: 125995-03-1
CAS Name: 5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
Percent Composition: C 73.31%, H 6.15%, F 3.51%, N 5.18%, O 11.84%
Properties: mp 159.2-160.7°. [a]D +26.05° (c = 1 in chloroform).
Melting point: mp 159.2-160.7°
Optical Rotation: [a]D +26.05° (c = 1 in chloroform)
Therap-Cat: Antilipemic.
Keywords: Antilipemic; HMG CoA Reductase Inhibitors; HMG CoA Reductase Inhibitor.
产品链接: 134523-00-5››