网站主页>>>项目整合精选>>>项目整合精选>>>Lobenzarit CAS Registry Number: 63329-53-3 2-((2-羧基苯基)氨基)-4-氯苯甲酸

Lobenzarit CAS Registry Number: 63329-53-3 2-((2-羧基苯基)氨基)-4-氯苯甲酸

CAS Name: 2-[(2-Carboxyphenyl)amino]-4-chlorobenzoic acid
Additional Names: N-(2-carboxyphenyl)-4-chloroanthranilic acid; 4-chloro-2,2'-iminodibenzoic acid; CCA
Percent Composition: C 57.65%, H 3.46%, Cl 12.15%, N 4.80%, O 21.94%

📌 参考资料/链接：
Literature References: Disease modifying antirheumatic drug (DMARD) with immunomodulating activity. Prepn: M. Tanemura et al., DE 2526092; eidem, US 4092426 (1976, 1978 both to Chugai). HPLC determn in plasma: F. J. Schwende, S. W. Turner, Pharm. Res. 8, 523 (1991). Immunosuppression of B cell activity: S. Hirohata et al., Arthritis Rheum. 35, 168 (1992). Clinical trial in rheumatoid arthritis: Y. Shiokawa et al., J. Rheumatol. 11, 615 (1984); in systemic lupus erythematosus: S. Hirohata et al., Clin. Exp. Rheumatol. 12, 261 (1994). Review of pharmacology: R. González, D. Remirez, Invest. Allergol. Clin. Immunol. 7, 77-82 (1997).

📄 详细内容

Properties: Crystals, mp 306°. LD50 in male, female rats (mg/kg): 2100, 2600 orally (Tanemura).
Melting point: mp 306°
Toxicity data: LD50 in male, female rats (mg/kg): 2100, 2600 orally (Tanemura)
Derivative Type: Disodium salt
CAS Registry Number: 64808-48-6
Trademarks: Carfenil (Chugai)
Percent Composition: C 50.10%, H 2.40%, Cl 10.56%, N 4.17%, Na 13.70%, O 19.07%
Properties: Solid, mp 388° (dec).
Melting point: mp 388° (dec)
Therap-Cat: Antirheumatic.
Keywords: Antiarthritic/Antirheumatic.
产品链接: 63329-53-3››

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