CAS: 63329-53-3; 2-((2-Carboxyphenyl)Amino)-4-Chlorobenzoic Acid

该化合物是其分子结构,它影响其溶解性,稳定性和再活动.在安全和处理方面,与许多化学物质一样,Lobenzarit应谨慎管理,遵守适当的安全议定书,以减轻任何潜在危害.其药理学特征和行动机制是正在进行的研究的主题,目的是阐明其在临床环境中的功效和潜在副作用.

结构式图片

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CAS号123-51-3 异戊醇 | CAS号50-84-0 2,4-二氯苯甲酸 | CAS号7440-44-0 活性炭 | CAS号118-92-3 邻氨基苯甲酸 | CAS号64808-48-6 氯苯扎利二钠 | CAS号24782-72-7 3-chloro-5-carb... | CAS号80258-99-7 1-CHLORO-9,10-D...

合成工艺路线路线简述

    Lobenzarit (Disodium) 反应生成 氯苯扎利
    参考文献:Vebres,Andras;Balogh,Gyula
    标题:Vebres,Andras;Balogh,Gyula

    海关参考信息

    专利信息


    专利号:US-2019152962-A1
    优先权日:2016-07-14
    标题 :Cyclopropyl derivatives as ror-gamma modulators
    发明人:DESAI RANJIT; KUMAR SANJAY S; PANDYA VRAJESH; DESAI JIGAR; RAVAL SAURIN
    权利人:CADILA HEALTHCARE LTD
    摘要:The present invention provides compounds which are modulators of RORγ and their use for the treatment of diseases or conditions mediated by RORγ. Further, the present invention relates to processes of preparing such compounds, their tautomeric forms, novel intermediates involved in their synthesis, their pharmaceutically acceptable salts, methods for using such compounds and pharmaceutical compositions containing them (Formula I).

    专利号:WO-2018011747-A1
    优先权日:2016-07-14
    标 题 :Polycyclic compounds as ror-gamma modulators
    发明人:DESAI RANJIT; KUMAR SANJAY S; PANDYA VRAJESH; DESAI JIGAR; RAVAL SAURIN
    权利人:CADILA HEALTHCARE LTD
    摘要:The present invention provides compounds which are modulators of RORγ and their use for the treatment of diseases or conditions mediated by RORγ. Further, the present invention relates to processes of preparing such compounds, their tautomeric forms, novel intermediates involved in their synthesis, their pharmaceutically acceptable salts, methods for using such compounds and pharmaceutical compositions containing them.

    专利号:US-9023384-B2
    优先权日:2004-11-02
    标题:Liposome and method for injecting substance to cell using this liposome
    发明人:MORITA IKUO; AKIYOSHI KAZUNARI; NOMURA SHINICHIRO
    权利人:MORITA IKUO; AKIYOSHI KAZUNARI; NOMURA SHINICHIRO; UNIV TOKYO MEDICAL & DENTAL; DAINIPPON PRINTING CO LTD
    摘要:It is intended to efficiently inject into a target cell, a substance charged within a liposome. The present inventors have found that connexin synthesized within a liposome is introduced as connexon having a gap junction function into the liposome membrane. Specifically, the liposome according to the present invention is a liposome in which connexon composed of connexin synthesized by an in-vitro protein synthesis system is incorporated in a state of having a gap junction function.

    专利号:WO-2018193297-A1
    优先权日:2017-04-21
    标题:Novel compounds as ror-gamma modulators
    发明人:SHARMA RAJIV; KUMAR SANJAY; SRIVASTAVA BRIJESH KUMAR
    权利人:CADILA HEALTHCARE LTD
    摘要:The present invention provides compounds which are modulators of RORÏ’ and their use for the treatment of diseases or conditions mediated by RORÏ’. Further, the present invention relates to processes of preparing such compounds, their tautomeric forms, deuterated form, novel intermediates involved in their synthesis, their pharmaceutically acceptable salts, methods for using such compounds and pharmaceutical compositions containing them. formula (I)
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    主要参考文献


    1: Evans GL, Gamage SA, Bulloch EM, Baker EN, Denny WA, Lott JS. Repurposing the chemical scaffold of the anti-arthritic drug Lobenzarit to target tryptophan biosynthesis in Mycobacterium tuberculosis. Chembiochem. 2014 Apr 14;15(6):852-64. doi: 10.1002/cbic.201300628. Epub 2014 Mar 12. Erratum in: Chembiochem. 2015 Mar 23;16(5):706. Chembiochem. 2015 Mar 23;16(5):706. doi: 10.1002/cbic.201500098. Epub 2015 Mar 11. Review. doi: 10.1016/j.ejps.2009.07.013. Epub 2009 Aug 8. Review. Japanese.

    合成参考文献


    摘要:Matsubara T, Minakuchi R, Tanaka Y, Hirohata K. The effect of N-(2-carboxyphenyl)-4-chloroantranilic acid disodium salt (CCA) on concanavalin A-induced superoxide anion release in human mononuclear phagocytes. Clin Exp Rheumatol. 1986 Jul;4(3):243–7.
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