专利号:US-2019152962-A1 优先权日:2016-07-14 标题 :Cyclopropyl derivatives as ror-gamma modulators 发明人:DESAI RANJIT; KUMAR SANJAY S; PANDYA VRAJESH; DESAI JIGAR; RAVAL SAURIN 权利人:CADILA HEALTHCARE LTD 摘要:The present invention provides compounds which are modulators of RORγ and their use for the treatment of diseases or conditions mediated by RORγ. Further, the present invention relates to processes of preparing such compounds, their tautomeric forms, novel intermediates involved in their synthesis, their pharmaceutically acceptable salts, methods for using such compounds and pharmaceutical compositions containing them (Formula I).
专利号:WO-2018011747-A1 优先权日:2016-07-14 标 题 :Polycyclic compounds as ror-gamma modulators 发明人:DESAI RANJIT; KUMAR SANJAY S; PANDYA VRAJESH; DESAI JIGAR; RAVAL SAURIN 权利人:CADILA HEALTHCARE LTD 摘要:The present invention provides compounds which are modulators of RORγ and their use for the treatment of diseases or conditions mediated by RORγ. Further, the present invention relates to processes of preparing such compounds, their tautomeric forms, novel intermediates involved in their synthesis, their pharmaceutically acceptable salts, methods for using such compounds and pharmaceutical compositions containing them.
专利号:US-9023384-B2 优先权日:2004-11-02 标题:Liposome and method for injecting substance to cell using this liposome 发明人:MORITA IKUO; AKIYOSHI KAZUNARI; NOMURA SHINICHIRO 权利人:MORITA IKUO; AKIYOSHI KAZUNARI; NOMURA SHINICHIRO; UNIV TOKYO MEDICAL & DENTAL; DAINIPPON PRINTING CO LTD 摘要:It is intended to efficiently inject into a target cell, a substance charged within a liposome. The present inventors have found that connexin synthesized within a liposome is introduced as connexon having a gap junction function into the liposome membrane. Specifically, the liposome according to the present invention is a liposome in which connexon composed of connexin synthesized by an in-vitro protein synthesis system is incorporated in a state of having a gap junction function.
专利号:WO-2018193297-A1 优先权日:2017-04-21 标题:Novel compounds as ror-gamma modulators 发明人:SHARMA RAJIV; KUMAR SANJAY; SRIVASTAVA BRIJESH KUMAR 权利人:CADILA HEALTHCARE LTD 摘要:The present invention provides compounds which are modulators of RORÏ’ and their use for the treatment of diseases or conditions mediated by RORÏ’. Further, the present invention relates to processes of preparing such compounds, their tautomeric forms, deuterated form, novel intermediates involved in their synthesis, their pharmaceutically acceptable salts, methods for using such compounds and pharmaceutical compositions containing them. formula (I)
1: Evans GL, Gamage SA, Bulloch EM, Baker EN, Denny WA, Lott JS. Repurposing the chemical scaffold of the anti-arthritic drug Lobenzarit to target tryptophan biosynthesis in Mycobacterium tuberculosis. Chembiochem. 2014 Apr 14;15(6):852-64. doi: 10.1002/cbic.201300628. Epub 2014 Mar 12. Erratum in: Chembiochem. 2015 Mar 23;16(5):706. Chembiochem. 2015 Mar 23;16(5):706. doi: 10.1002/cbic.201500098. Epub 2015 Mar 11. Review. doi: 10.1016/j.ejps.2009.07.013. Epub 2009 Aug 8. Review. Japanese.
合成参考文献
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