Lophotoxin CAS Registry Number: 78697-56-0 11,16,18,19-四氧甲酰四环[12.2.2.16,9.01,15.010,12]九烷基-6,8-二烯-7-羧醛,2-(乙酰氧)-12-甲基-4-(1-甲基乙基)-17-氧基-,(1R,2S,4S,10R,12R,14R,15R)-

📌 参考资料/链接：
Literature References: A novel neuromuscular toxin isolated from several spp of Pacific gorgonians (sea fans and whips) of the genus Lophogorgia. Although it belongs to the cembrene class of diterpenoids, the ability of LTX to cause irreversible postsynaptic blockade at the neuromuscular junction resembles the mode of action of the protein snake venom a-bungarotoxin (cf. bungarotoxins). Isoln and structure: W. Fenical et al., Science 212, 1512 (1981). Molecular mode of action: J. R. Smythies, Med. Hypotheses 7, 1457 (1981), C.A. 96, 137527 (1982). Toxicity study: P. Culver, R. S. Jacobs, Toxicon 19, 825 (1981). Description of the cytotoxic, ichthytoxic, and antibacterial activity of alcoholic extracts of gorgonians: R. S. Jacobs et al., Fed. Proc. 40, 26 (1981); V. J. Paul, W. Fenical, J. Org. Chem. 45, 3401 (1981).