其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Eosine Yellowish ¾ (YS) CAS Registry Number: 17372-87-1 曙红Y(水溶)

CAS Name: 2',4',5',7'-Tetrabromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one disodium salt
Additional Names: 2',4',5',7'-tetrabromofluorescein; bromoeosine; tetrabromofluores...
Literature References: Xanthene dye capable of photodynamic generation of singlet oxygen. Prepd by bromination of fluorescein: Colour Index vol. 4 (3rd ed., 1971) p 4426. Photodynamic injury to leaf tissue and inhibition of photosynthesis: J. P. Knox, A. D. Dodge, Planta 164, 22; 30 (1985). Review: H. J. Conn's Biological Stains, R. D. Lillie, Ed. (Williams Wilkins, Baltimore, 9th ed., 1977), pp 342-344.

Febuxostat CAS Registry Number: 144060-53-7 非布索坦

CAS Name: 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid
Additional Names: 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acidPercent Composition: C 60....
Literature References: Xanthine oxidase/xanthine dehydrogenase inhibitor. Prepn: S. Kondo et al., EP 513379; eidem, US 5614520 (1992, 1997 both to Teijin). Synthesis: M. Hasegawa, Heterocycles 47, 857 (1998). Mechanism of action and crystal structure study: K. Okamoto et al., J. Biol. Chem. 278, 1848 (2003). Pharmacology: Y. Osada et al., Eur. J. Pharmacol. 241, 183 (1993). Clinical pharmacokinetics: M. D. Mayer et al., Am. J. Therap. 12, 22 (2005). Clinical evaluation in hyperuricemia and gout: M. A. Becker et al., N. Engl. J. Med. 353, 2450 (2005). Review of clinical development: B. Tomlinson, Curr. Opin. Invest. Drugs 6, 1168-1178 (2005).

Metrizamide CAS Registry Number: 31112-62-6 甲泛葡胺

CAS Name: 2-[[3-(Acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl]amino]-2-deoxy-D-glucose
Additional Names: 2-[3-acetamido-2,4,6-triiodo-5-(N-methylacetamido)benzamido]-2-deoxy-D-glucos...
Literature References: X-ray contrast agent related to metrizoic acid, q.v. Prepn: H. O. Torsten et al., DE 2031724; eidem, US 3701771 (1971, 1972 both to Nyegaard). Metabolism: J. G. Johansen, S. Kolmannskog, Invest. Radiol. 13, 93 (1978). Pharmacology: T. W. Morris et al., ibid. 74; G. F. Dibona, Proc. Soc. Exp. Biol. Med. 157, 453 (1978). Series of articles on clinical use: Ann. Radiol. 22, 195-206 (1979). Toxicity studies: S. Salvesen, Radiology 123, 241 (1977); M. Sovak et al., ibid. 242; P. Aspelin, Invest. Radiol. 11, 309 (1976). Review: L. Hol et al., in Pharmacological and Biochemical Properties of Drug Substances vol. 1, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1977) pp 387-412.

Lapachol CAS Registry Number: 84-79-7 黄钟花醌

CAS Name: 2-Hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione
Additional Names: lapachic acid; taiguic acid; tecomin; greenhartinPercent Composition: C 74.36%, H 5.82%, O 19.81%
Literature References: Yellow crystalline material derived from the heartwood of Asian and South American bignoniaceous plants, esp Surinam greenheart, Taigu wood, Lapacho heartwood and Bethabarra wood: Arnoudon, Compt. Rend. 41, 1152 (1857); Stein, J. Prakt. Chem. 99, 1 (1866); Paterno, Gazz. Chim. Ital. 9, 506 (1879); Greene, Hooker, Am. Chem. J. 11, 267 (1889). Structure: Paterno, Gazz. Chim. Ital. 12, 337 (1882); Hooker J. Chem. Soc. 61, 611 (1892); 69, 1355 (1896); J. Am. Chem. Soc. 58, 1168 (1936). Synthesis: Fieser, ibid. 49, 857 (1927); Hooker, ibid. 58, 1181 (1936); G. R. Pettit, L. E. Houghton, J. Chem. Soc. C 1971, 509. Although it is related structurally to vitamin K, q.v., it does not possess antihemorrhagic activity: H. J. Almquist, A. A. Klose, J. Am. Chem. Soc. 61, 1923 (1939); L. F. Fieser et al., J. Biol. Chem. 137, 659 (1941). It is reported to be an inhibitor of respiratory processes: E. G. Ball et al., ibid. 168, 257 (1947). Lapachol has also exhibited antitumor activity vs Walker 256 carcinoma: K. V. Rao et al., Proc. Am. Assoc. Cancer Res. 8, 55 (1967). Mass spectrometry: T. A. Elwood et al., Org. Mass Spectrom. 3, 841 (1970). Chromatographic detection: M. H. Simatupang et al., J. Chromatogr. 52, 180 (1970). Pharmacology: S. M. Sieber et al., Cancer Treat. Rep. 60, 1127 (1976). Toxicity study: R. K. Morrison et al., Toxicol. Appl. Pharmacol. 17, 1 (1970). Review of antitumor activity: K. V. Rao, Cancer Chemother. Rep. Part 2 4 (4), 11-17 (1974).

Chrysergonic Acid CAS Registry Number: 53092-91-4

Percent Composition: C 60.19%, H 4.74%, O 35.08%
Literature References: Yellow pigment from ergot. Diastereoisomer of secalonic acids.

CHES CAS Registry Number: 103-47-9 2-环己胺基乙磺酸(CHES)

CAS Name: 2-(Cyclohexylamino)ethanesulfonic acid
Additional Names: N-cyclohexyltaurine
Percent Composition: C 46.35%, H 8.27%, N 6.76%, O 23.16%, S 15.47%
Literature References: Zwitterionic N-substituted aminosulfonic acid in the style of the "Good" buffers; active in the pH range 8.6-10.0. Synthesis: A. Champseix et al., Bull. Soc. Chim. Fr. 1985, 463. Effects of freezing on buffering: D. L. Williams-Smith et al., Biochem. J. 167, 593 (1977). Effects on Lowry protein assay: C. Cookson, Anal. Biochem. 88, 340 (1978). Dissociation constants and buffering capacity: M. J. Taylor, Y. Pignat, Cryobiology 19, 99 (1982). Use as buffer: M. G. N. Hartmanis, T. C. Stadtman, Proc. Natl. Acad. Sci. USA 84, 76 (1987); C. Engstrand et al., Biochim. Biophys. Acta 1122, 321 (1992).

TAPS CAS Registry Number: 29915-38-6 N-三(羟甲基)甲基-3-氨基丙磺酸(TAPS)

CAS Name: 3-[[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]-1-propanesulfonic acid
Additional Names: N-tris[(hydroxymethyl)methyl]-3-aminopropanesulfonic acid
Percent Composition: C 34.56%, H...
Literature References: Zwitterionic N-substituted sulfonic acid in the style of the "Good" buffers; active in the pH range 6-8.5. Prepn: I. Zeid, I. Ismail, Ann. 1974, 667. Dissociation: A. M. El-Nady, H. A. Azab, Acta Chim. Hung. 130, 665 (1993). Use as eluent: R. H. P. Reid, J. Chromatogr. A 684, 221 (1994). Effect of buffer concentration on pH-activity relationship: C. G. Bevans, A. L. Harris, J. Biol. Chem. 274, 3711 (1999).

Perimycin CAS Registry Number: 11016-07-2

Additional Names: Aminomycin; fungimycinLiterature References: Polyene antifungal antibiotic complex produced by Streptomyces coelicolor var. aminophilus NRRL 2390: W. E. Wooldridge,
US
29...
Properties: Amorphous, golden-yellow solid. Has no definite mp but dec slowly with darkening upon heating. uv max (methanol): 383 nm (E1%1cm 1000). Sol in the following solvents in the presence of water: lower alcohols, pyridine, tetrahydrofuran, acetone, dioxane. Sol in warm methanol, DMF, dimethylsulfoxide, and in the lower fatty acids. Practically insol in water, petr ether, ethyl acetate, benzene.Absorption maximum: uv max (methanol): 383 nm (E1%1cm 1000)

Diisoamylamine CAS Registry Number: 544-00-3 二异戊胺

CAS Name: 3-Methyl-N-(3-methylbutyl)-1-butanamine
Additional Names: isodiamylamine
Percent Composition: C 76.36%, H 14.74%, N 8.90%
Properties: Liquid. d420 0.767. bp 188°. mp -44°. nD21 1.4229. Slightly sol in water; sol in alcohol, chloroform, ether.Melting point: mp -44°Boiling point: bp 188°Index of refraction: nD21 1.4229Density: d420 0.767

Ramoplanin CAS Registry Number: 76168-82-6 雷莫拉宁

Additional Names: A-16686Literature References: Glycolipodepsipeptide antibiotic complex consisting of 6 related components (A1, A2, A3, A'1, A'2, A'3) of which A2 is the most abundant. Isoln and ...
Properties: White powder, slightly hygroscopic. mp 210-230°. [a]D20 +78.3° (c = 1.04 in H2O). Sol in DMF and lower alcohols. Insol in ethyl ether, petroleum ether and benzene. LD50 in mice (mg/kg): 328 i.p., 122 i.v.; orally in rats: 2000 mg/kg (Pallanza).Melting point: mp 210-230°Optical Rotation: [a]D20 +78.3° (c = 1.04 in H2O)Toxicity data: LD50 in mice (mg/kg): 328 i.p., 122 i.v.; orally in rats: 2000 mg/kg (Pallanza)