其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Isomaltol CAS Registry Number: 3420-59-5 1-(3-羟基-2-呋喃基)乙酮

CAS Name: 1-(3-Hydroxy-2-furanyl)ethanone
Additional Names: 3-hydroxy-2-furyl methyl ketone
Percent Composition: C 57.14%, H 4.80%, O 38.06%
Literature References: Trace constituent of bread. Obtained by the action of enzymes on starch: Backe, Compt. Rend. 151, 78 (1910). Synthesis from a-lactose and a secondary amine: Hodge, Nelson, US 3054805 (1962 to USDA). Structure: Hodge, Nelson, Cereal Chem. 38, 207 (1961); Fischer, Hodge, J. Org. Chem. 29, 776 (1964).

Stilbene CAS Registry Number: 588-59-0 二苯乙烯

CAS Name: 1,1'-(1,2-Ethenediyl)bis[benzene]
Additional Names: a,b-diphenylethylene; bibenzal; bibenzylidene
Percent Composition: C 93.29%, H 6.71%
Literature References: trans-Form prepd by Clemmensen reduction of benzoin: Shriner, Berger, Org. Synth. coll. vol. III, 786 (1955); cis-form by copper-chromite decarboxylation of a-phenylcinnamic acid: Buckles, Wheeler, ibid. coll. vol. IV, 857 (1963). Synthesis of cis- and trans-forms by the Wittig reaction and by decarboxylation of phenylcinnamic acids: Wheeler, Batlle de Pabon, J. Org. Chem. 30, 1473 (1965).

Dichloroacetic Acid CAS Registry Number: 79-43-6 二氯乙酸

Additional Names: Bichloracetic acid; dichlorethanoic acid; DCA
Percent Composition: C 18.63%, H 1.56%, Cl 54.99%, O 24.82%
Literature References: Transformation of chloral to dichloroacetic acid: Wallach, Ann. 173, 288 (1874); Frantzen, Fikentscher, ibid. 623, 68 (1959); Rosenblum et al., Chem. Ind. (London) 1960, 718. Toxicity: Smyth et al., Arch. Ind. Hyg. Occup. Med. 4, 119 (1951); P. W. Stacpoole et al., N. Engl. J. Med. 300, 372 (1979); J. L. Cicmanec et al., Fundam. Appl. Toxicol. 17, 376 (1991). Mutagenicity studies: V. Herbert et al., Am. J. Clin. Nutr. 33, 1179 (1980). Use in treatment of lactic acidosis: P. W. Stacpoole et al., N. Engl. J. Med. 309, 390 (1983).

Toltrazuril CAS Registry Number: 69004-03-1 托曲珠利

CAS Name: 1-Methyl-3-[3-methyl-4-[4-[(trifluoromethyl)thio]phenoxy]phenyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione
Additional Names: 1-methyl-3-[4-[p-[(trifluoromethyl)thio]phenoxy]-m-tolyl]-s-tr...
Literature References: Triazinetrione anticoccidial. General prepn: BE 826900; J. H. Reisdorff et al., US 3966725 (1975, 1976 both to Bayer). Prepn and use as animal growth promotant: BE 866389; A. Haberkorn et al., US 4219552 (1978, 1980 both to Bayer). Series of articles on efficacy vs coccidia in chickens: E. Kutzer et al., Wien. Tieraerztl. Monatssch. 72, 321-340 (1985). Field trial in sheep: B. Gjerde, O. Helle, Acta Vet. Scand. 27, 124 (1986); in chickens: H. D. Chapman, J. Comp. Pathol. 97, 21 (1987).

Propoxycarbazone CAS Registry Number: 145026-81-9

CAS Name: 2-[[[(4,5-Dihydro-4-methyl-5-oxo-3-propoxy-1H-1,2,4-triazol-1-yl)carbonyl]amino]sulfonyl]benzoic acid methyl ester
Additional Names: methyl 2-[[[(4-methyl-5-oxo-3-propoxy-4,5-dihydro-...
Literature References: Triazolinone graminicide for use in cereal crops; acetolactate synthase inhibitor. Prepn: K.-H. Müller et al., EP 507171; eidem, US 5534486 (1992, 1996 both to Bayer). Review of properties and field trials: D. Feucht et al., Brighton Crop Prot. Conf. - Weeds 1999, 53-58. Absorption and fate in weeds: L. Fandrich et al., Weed Sci. 49, 717 (2001).

Amicarbazone CAS Registry Number: 129909-90-6 胺唑草酮

CAS Name: 4-Amino-N-(1,1-dimethylethyl)-4,5-dihydro-3-(1-methylethyl)-5-oxo-1H-1,2,4-triazole-1-carboxamide
Additional Names: 4-amino-1-(N-t-butylcarbamoyl)-3-isopropyl-1,2,4-triazolin-5-one; 4...
Literature References: Triazolinone herbicide for use in food crops. Prepn: K.-H. Müller et al., DE 3839206; M. Lindig et al., US 5194085 (1990, 1993 both to Bayer). Comprehensive description: B. D. Philbrook et al., Brighton Crop Prot. Conf. - Weeds 1999, 29-34.

Adinazolam CAS Registry Number: 37115-32-5 阿地唑仑

CAS Name: 8-Chloro-N,N-dimethyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-1-methanamine
Additional Names: 8-chloro-1-[(dimethylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzod...
Literature References: Triazolobenzodiazepine; dimethylamino derivative of alprazolam, q.v. Prepn: H. Allgeier, A. Gagneux, DE 2201210; GB 1393256 (1972, 1975 both to Ciba-Geigy); J. B. Hester, Jr., US 4250094 (1984 to Upjohn); idem, J. Heterocycl. Chem. 17, 575 (1980). Chromatographic determn in human plasma: G. W. Peng, J. Pharm. Sci. 73, 1173 (1984). Pharmacological profile: R. A. Lahti et al., Neuropharmacology 22, 1277 (1983). Biological activity and metabolism: V. H. Sethy et al., J. Pharm. Pharmacol. 36, 546 (1984). Preliminary clinical study in severe depression: R. E. Pyke et al., Psychopharmacol. Bull. 19, 96 (1983).

Florasulam CAS Registry Number: 145701-23-1 双氟磺草胺

CAS Name: N-(2,6-Difluorophenyl)-8-fluoro-5-methoxy-[1,2,4]triazolo[l,5-c]pyrimidine-2-sulfonamide
Additional Names: 2',6',8-trifluoro-5-methoxy-s-triazolo[1,5-c]pyrimidine-2-sulfonanilide
T...
Literature References: Triazolopyrimidine herbicide for use in cereals. Acetolactate synthase (ALS) inhibitor. Prepn: J. C. Van Heertum et al., WO 8911782 (1989 to Dow); eidem, US 5163995 (1992 to DowElanco). Comprehensive description: A. R. Thompson et al., Brighton Crop Prot. Conf. - Weeds 1999, 73-80. Review of field trials: A. D. Bailey et al., ibid. 205-209. Photolytic degradation in soil and water: M. S. Krieger et al., J. Agric. Food Chem. 48, 3710 (2000).

Penoxsulam CAS Registry Number: 219714-96-2 五氟磺草胺

CAS Name: 2-(2,2-Difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamideTrademarks: Granite (Dow AgroSci.); Grasp (Dow AgroSci.); Viper (Dow Agr...
Literature References: Triazolopyrimidine sulfonamide herbicide for weed control in rice; inhibits acetolactate synthase (ALS). Prepn: T. C. Johnson et al., US 5858924 (1999 to Dow AgroSciences). Dissipation study in rice fields: D. W. Roberts et al., Proc. 12th Symp. Pestic. Chem. 2003, 349. Comprehensive review: D. Larelle et al., BCPC Int. Congr. - Crop Sci. Technol. 2003, 75-80.

Nortriptyline CAS Registry Number: 72-69-5 去甲替林

CAS Name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Additional Names: 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-D5,g-propylamine; 5-(a-methylaminopr...
Literature References: Tricyclic antidepressant. Prepn: Hoffsommer et al., J. Org. Chem. 27, 4134 (1962); NL 6408512; E. I. Engelhardt, US 3922305 (1965, 1975 both to Merck Co.). Alternative process: N. L. Wendler, US 3442949 (1969 to Merck Co.). GC determn in plasma: J. E. Burch, J. Chromatogr. 308, 165 (1984). Determn in plasma or serum by radioimmunoassay: J. F. Sayegh, Neurochem. Res. 11, 193 (1986). Pharmacokinetics: E. H. Rubin et al., J. Clin. Psychiatry 46, 418 (1985). Clinical trial in post-stroke depression: J. R. Lipsey et al., Lancet 1, 297 (1984). Anticholinergic effect and clinical efficacy in urinary dysfunction: I. Nissenkorn et al., Eur. Urol. 12, 109 (1986). Comprehensive description: J. L. Hale, Anal. Profiles Drug Subs. 1, 233-247 (1972).