其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Ibuproxam CAS Registry Number: 53648-05-8 异丁普生

CAS Name: N-Hydroxy-a-methyl-4-(2-methylpropyl)benzeneacetamide
Additional Names: dl-2-(4-isobutylphenyl)propionohydroxamic acidTrademarks: Ibudros (Manetti Roberts)
Percent Composition: C 7...
Literature References: Hydroxylamine deriv of ibuprofen, q.v., to which it is converted in vivo. Prepn: G. Orzalesi, R. Selleri, DE 2400531; eidem, US 4082707 (1974, 1978 both to Manetti Roberts). Metabolism in rats: G. Orzalesi et al., Arzneim.-Forsch. 27, 1012 (1977); in humans: eidem, ibid. 30, 1607 (1980). Pharmacological study: eidem, ibid. 27, 1006 (1977). Thermal decomposition: S. Chimichi et al., J. Pharm. Sci. 69, 521 (1980). Physico-chemical properties: M. Mannelli et al., Boll. Chim. Farm. 119, 203 (1980).

Ceronapril CAS Registry Number: 111223-26-8 西罗普利

CAS Name: 1-[(2S)-6-Amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L-proline
Additional Names: 1-[(2S)-6-amino-2-hydroxyhexanoyl]-L-proline, hydrogen (4-phenylbutyl)phosphonate (es...
Literature References: Hydroxylphosphonate angiotensin converting enzyme (ACE) inhibitor. Prepn: D. S. Karanewsky, E. W. Petrillo, Jr., EP 97534; eidem, US 4452790 (both 1984 to Squibb); eidem et al., J. Med. Chem. 31, 204 (1988). HPLC determn in body fluids: H. Kadin et al., J. Chromatogr. 487, 135 (1989). Pharmacology: J. M. DeForrest et al., J. Cardiovasc. Pharmacol. 16, 121 (1990). Radioimmunoassay and pharmacokinetics: J. Tu et al., Ther. Drug Monit. 14, 209 (1992). Clinical evaluation in hypertension: J. Sasaki et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 31, 83 (1993).

Atovaquone CAS Registry Number: 95233-18-4 阿托伐醌

CAS Name: 2-[trans-4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione
Additional Names: trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinoneTrademarks: Mepron (GSK); We...
Literature References: Hydroxynaphthoquinone derivative that inhibits mitochondrial electron transport. Prepn: A. T. Hudson, A. W. Randall, EP 123238; eidem, US 5053432 (1984, 1991 both to Burroughs Wellcome). Antiprotozoal activity, metabolism, and pharmacokinetics: A. T. Hudson et al., Drugs Exp. Clin. Res. 17, 427 (1991). Mechanism of action study: M. Fry, M. Pudney, Biochem. Pharmacol. 43, 1545 (1992). Clinical trial for prevention of pneumocystis pneumonia in AIDS patients: W. M. El-Sadr et al., N. Engl. J. Med. 339, 1889 (1998).

Schwartz's Reagent CAS Registry Number: 37342-97-5 双(环戊二烯)二氯氢化锆

CAS Name: Chlorobis(h5-2,4-cyclopentadien-1-yl)hydrozirconium
Additional Names: Cp2Zr(H)Cl; (h5-C5H5)2Zr(H)Cl
Percent Composition: C 46.58%, H 4.30%, Cl 13.75%, Zr 35.38%
Literature References: Hydrozirconation reducing agent for a range of unsaturated compounds. Prepn: P. C. Wailes, H. Weigold, J. Organomet. Chem. 24, 405 (1970); with high yield: S. L. Buchwald et al., Tetrahedron Lett. 28, 3895 (1987); in situ prepn: B. H. Lipshutz et al., ibid. 31, 7257 (1990). Stereoselectivity: E. Cesarotti et al., Inorg. Chim. Acta 64, L207 (1982). Use as general reducing agent: J. Schwartz, J. A. Labinger, Angew. Chem. Int. Ed. 15, 333 (1976); reduction of halides in presence of triethylborane, q.v.: K. Fujita et al., J. Am. Chem. Soc. 123, 3137 (2001); in silylation of alkenes: J. Terao et al., Tetrahedron 60, 1301 (2004). Review of applications in phosphorous chemistry: J.-P. Majoral et al., Ber. 129, 879-886 (1996); of mechanism and reduction of amides: J. M. White et al., Chem. Innovation 30, 23-28 (2000).

o-Iodoxybenzoic Acid CAS Registry Number: 64297-64-9; 61717-82-6 (cyclic tautomer) 2-碘酰苯甲酸

CAS Name: 2-Iodylbenzoic acid
Additional Names: 1-hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide; IBX; 2-iodoxybenzoic acid
Percent Composition: C 30.02%, H 1.80%, I 45.32%, O 22.85%
Literature References: Hypervalent 10-I-4 iodine reagent; cyclic tautomer is the predominant molecular structure. Prepn: C. Hartmann, V. Meyer, Ber. 26, 1727 (1893); F. R. Greenbaum, Am. J. Pharm. 108, 17 (1936); and conversion to stable 12-I-5 periodinanes: D. B. Dess, J. C. Martin, J. Am. Chem. Soc. 113, 7277 (1991). Improved prepn: M. Frigerio et al., J. Org. Chem. 64, 4537 (1999). Prepn of a stabilized, nonexplosive formulation: D. Depernet, B. Francois, US 6462227 (2002 to Simafex). IR analysis: R. Bell, K. J. Morgan, J. Chem. Soc. 1960, 1209. Crystal structure: J. Z. Gougoutas, Acta Crystallogr. 10, 489 (1981). 13C NMR analysis: A. R. Katritzky et al., Magn. Reson. Chem. 27, 1007 (1989). Oxidizing properties and reaction conditions: M. Frigerio et al., J. Org. Chem. 60, 7272 (1995). Kinetics and mechanism of oxidation reactions: S. De Munari et al., ibid. 61, 9272 (1996). Characterization of crystallographic forms: P. J. Stevenson et al., J. Chem. Soc. Perkin Trans. 2 1997, 589. Brief review of chemistry: T. Wirth, Angew. Chem. Int. Ed. 40, 2812-2814 (2001).

Phenyliodine(III) Bis(trifluoroacetate) CAS Registry Number: 2712-78-9 [双(三氟乙酰氧基)碘]苯

CAS Name: Phenylbis(trifluoroacetato-kO)iodine
Additional Names: bis(trifluoroacetoxy)iodobenzene; iodobenzene ditrifluoroacetate; PIFA
Literature References: Hypervalent iodine(III) reagent. Prepn: N. W. Alcock, T. C. Waddington, J. Chem. Soc. 1963, 4103; I. I. Maletina et al., J. Org. Chem. USSR 10, 294 (1974). Structural study: N. W. Alcock et al., J. Chem. Soc. Dalton Trans. 1984, 1709. Use as a one-electron oxidant: L. Eberson et al., Acta Chem. Scand. 49, 640 (1995). Review of applications in organic synthesis: G. Pohnert, J. Prakt. Chem. 342, 731-734 (2000).

Eritadenine CAS Registry Number: 23918-98-1 4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸

CAS Name: (aR,bR)-6-Amino-a,b-dihydroxy-9H-purine-9-butanoic acid
Additional Names: 2(R),3(R)-dihydroxy-4-(9-adenyl)butyric acid; 4-(6-amino-9H-purin-9-yl)-4-deoxy-D-erythronic acid; lentinacin...
Literature References: Hypocholesterolemic principle isolated from the Shiitake mushroom, Lentinus edodes Sing. Isoln, activity and structure: I. Chibata et al., Experientia 25, 1237 (1969). Synthesis: T. Kamiya et al., J. Heterocycl. Chem. 9, 359 (1972). GC/MS determn in mushroom extracts: G. Vitányi et al., Rapid Commun. Mass Spectrom. 12, 120 (1998). Effect on phospholipid metabolism: K. Sugiyama et al., J. Nutr. 125, 2134 (1995); on linoleic acid metabolism: idem et al., Lipids 32, 859 (1997).

Mitiglinide CAS Registry Number: 145375-43-5 米格列奈

CAS Name: (aS,3aR,7aS)-Octahydro-g-oxo-a-(phenylmethyl)-2H-isoindole-2-butanoic acid
Additional Names: (2S)-2-benzyl-3-(cis-hexahydroisoindolin-2-ylcarbonyl)propionic acid
Percent Compositio...
Literature References: Hypoglycemic agent for treatment of type 2 diabetes. Prepn: F. Sato et al., EP 507534; eidem, US 5202335 (1992, 1993 both to Kissei); T. Yamaguchi et al., Chem. Pharm. Bull. 45, 1518 (1997); eidem, ibid. 46, 337 (1998). Improved synthesis: J. Liu et al., Helv. Chim. Acta 87, 1935 (2004). 2D-NMR conformation study: L. Lins et al., Biochem. Pharmacol. 52, 1155 (1996). Mechanism of action studies: F. Reimann et al., Br. J. Pharmacol. 132, 1542 (2001); N. Kaiser et al., ibid. 146, 872 (2005). Clinical evaluation in type 2 diabetes: R. Assaloni et al., Diabetologia 48, 1919 (2005).

Hypoglycine A CAS Registry Number: 156-56-9 (2S)-2-氨基-3-[(1S)-2-亚甲基环丙基]丙酸

CAS Name: (aS,1R)-a-Amino-2-methylenecyclopropanepropanoic acid
Additional Names: 2-methylenecyclopropanealanine; 2-amino-4,5-methylenehex-5-enoic acid; a-amino-b-(2-methylenecyclopropyl)propio...
Literature References: Hypoglycemic principle from the akee plant, Blighia sapida Kon., Sapindaceae: Hassall et al., Nature 173, 356 (1954); Hassall, Reyle, Biochem. J. 60, 334 (1955). Structure: de Ropp et al., J. Am. Chem. Soc. 80, 1004 (1958); Renner et al., Helv. Chim. Acta 41, 589 (1958); Ellington et al., J. Chem. Soc. 1959, 80. Synthesis: Carbon et al., J. Am. Chem. Soc. 80, 1002 (1958); Black, Landor, Tetrahedron Lett. 1963, 1065.

Ciprofibrate CAS Registry Number: 52214-84-3 环丙贝特

CAS Name: 2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
Additional Names: 2-[4-(2,2-dichlorocyclopropyl)phenoxy]isobutyric acidTrademarks: Ciprol (Sterling); Lipanor (Winthrop);...
Literature References: Hypolipemic agent, related structurally to clofibrate, q.v. Prepn: D. K. Phillips, DE 2343606 ; idem, US 3948973 (1974, 1976 both to Sterling). Pharmacokinetics in animals and man: C. Davison et al., Drug Metab. Dispos. 3, 520 (1975). Inhibition of cholesterol biosynthesis in rats: A. Arnold et al., Atherosclerosis 32, 155 (1979). Blood levels, distribution, duration of action: J. Edelson et al., ibid. 33, 351 (1979). Metabolic effects: A. Arnold et al., J. Pharm. Sci. 68, 1557 (1979). Teratology study: H. Tuchman-Duplessis et al., Toxicology 12, 1 (1979).