其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Cocaethylene CAS Registry Number: 529-38-4 可卡乙碱

CAS Name: [1R-(exo,exo)]-3-(Benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid ethyl ester
Additional Names: ecgonine ethyl ester benzoate (ester); O-benzoyl-l-ecgonine ethyl este...
Literature References: Homolog of cocaine. Prepn: Merck, Ber. 18, 2952 (1885); Einhorn, ibid. 21, 47 (1888).

Hopantenic Acid CAS Registry Number: 18679-90-8 4-[[(2R)-2,4-二羟基-3,3-二甲基-1-氧代丁基]氨基]-丁酸

CAS Name: 4-[[(2R)-2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl]amino]butanoic acid
Additional Names: D-(+)-4-(2,4-dihydroxy-3,3-dimethylbutyramido)butyric acid; D-homopantothenic acid
Percent Comp...
Literature References: Homolog of pantothenic acid, q.v. Prepn: R. Fuerst, L. L. Li, Biochim. Biophys. Acta 86, 26 (1964); C. M. DeSha, R. Fuerst, ibid. 33. Prepn of the calcium salt: Y. Nishizawa et al., JP 66 732 (1966 to Tanabe), C.A. 64, 12555c (1965). Series of articles on analysis, physicochemical properties, electrophysiology, pharmacology, toxicity studies, teratology: Bitamin 33, 603-632 (1966), C.A. 65, 5949a-g (1966). Colorimetric determn, properties: T. Kodama et al., J. Vitaminol. 13, 298 (1967), C.A. 68, 62755n (1968). Peri- and postnatal studies in rats: Y. Asano et al., Oyo Yakuri 19, 1011 (1980), C.A. 94, 58160 (1981). Mechanism of action: V. M. Arakumov, M. A. Kovler, Farmakol. Toksikol. 44, 30 (1981), C.A. 94, 114577 (1981). Determn in plasma: Y. Umeno et al., J. Chromatogr. 226, 333 (1981). Toxicology studies: Y. Nishizawa et al., J. Vitaminol. 15, 26 (1969). Pharmacology and acute toxicity study: Y. Nishizawa, Med. J. Osaka Univ. 35, 41 (1984).

Povidone CAS Registry Number: 9003-39-8 聚乙烯吡咯烷酮

CAS Name: 1-Ethenyl-2-pyrrolidinone homopolymer
Additional Names: 1-vinyl-2-pyrrolidinone polymers; poly[1-(2-oxo-1-pyrrolidinyl)ethylene]; polyvinylpyrrolidone; polyvidone; PVP
Trademarks: ...
Literature References: Homopolymer of N-vinyl-2-pyrrolidone, produced commercially as a series of products having mean mol wts ranging from 2,500 to 1,000,000. Prepd by free radical polymerization of the monomer. See J. W. Reppe, Acetylene Chemistry (PB Report 18852-s, U.S. Dept. Commerce, 1949) pp 68-72. Review of clinical use and early literature: W. Wessel et al., Arzneim.-Forsch. 21, 1468-1482 (1971); of synthesis and physical properties: H. Warson, Polym. Paint Colour J. 161, 637-644 (1972); F. Haaf et al., Polym. J. 17, 143-152 (1985); of use in cosmetics: F. G. M. Vogel, Soap Cosmet. Chem. Spec. 65, 42-47, 128 (1989). Book: PVP: A Critical Review of the Kinetics and Toxicology of Polyvinylpyrrolidone (Povidone), B. V. Robinson et al., Eds. (Lewis Publishers, Chelsea, MI, 1990) 209 pp. Comprehensive description: C. M. Adeyeye, E. Barabas, Anal. Profiles Drug Subs. Excip. 22, 555-685 (1993). Size exclusion chromatography: C. Wu et al., Chromatogr. Sci. Ser. 69, 311 (1995).

Clofencet CAS Registry Number: 129025-54-3 2-(4-氯苯基)-3-乙基-5-氧代-2,5-二氢哒嗪-4-羧酸

CAS Name: 2-(4-Chlorophenyl)-3-ethyl-2,5-dihydro-5-oxo-4-pyridazinecarboxylic acidPercent Composition: C 56.03%, H 3.98%, Cl 12.72%, N 10.05%, O 17.22%
Literature References: Hybridizing agent for wheat. Prepn: D. R. Patterson, EP 49971; idem, US 4732603 (1982, 1988 both to Rohm Haas). Improved prepn: J. D. Clark et al., Org. Process Res. Dev. 8, 176 (2004). Sorption behavior in soils: I. G. Dubus et al., Chemosphere 45, 767 (2001). Comprehensive description: Clofencet Pesticide Fact Sheet (U.S. EPA, Feb. 1997) 12 pp.

Ferric Sodium Pyrophosphate CAS Registry Number: 10045-87-1 铁钠焦磷酸盐

Additional Names: Sodium ferric pyrophosphate
Percent Composition: Fe 17.49%, Na 14.40%, O 43.85%, P 24.25%
Literature References: Hydrate; Na8Fe4(P2O7).xH2O. The commercial product contains 15.5-16.5% Fe and 50.5-52.5% P2O5.

Negamycin CAS Registry Number: 33404-78-3 2-[[(3,6-二氨基-5-羟基己烷酰基)氨基]-甲基氨基]乙酸

CAS Name: 3,6-Diamino-2,3,4,6-tetradeoxy-L-threo-hexonic acid 2-(carboxymethyl)-2-methylhydrazide
Additional Names: 3,6-diamino-5-hydroxyhexanoic acid 2-(carboxymethyl)-2-methylhydrazide; [2-(3...
Literature References: Hydrazide antibiotic isolated from strains related to Streptomyces purpeofuscus: Hamada et al., J. Antibiot. 23, 170 (1970). Prepn: H. Umezawa et al., ZA 7002933; eidem, US 3679742 (1970, 1972 both to Microbiochem. Res. Found.). Structure and partial synthesis: Kondo et al., J. Am. Chem. Soc. 93, 6305 (1971). Total synthesis of negamycin and its antipode: Shibahara et al., ibid. 94, 4353 (1972). Synthesis of racemic negamycin: W. Streicher et al., J. Antibiot. 31, 725 (1978); G. Pasquet et al., Tetrahedron Lett. 21, 931 (1980); A. Pierdet et al., Tetrahedron 36, 1763 (1980). Stereocontrolled synthesis of (+)-negamycin: Y. F. Wang et al., J. Am. Chem. Soc. 104, 6465 (1982); S. DeBernardo et al., Tetrahedron Lett. 29, 4077 (1988). Mechanism of action: Mizuno et al., J. Antibiot. 23, 581 (1970); Y. Uehara et al., Biochim. Biophys. Acta 442, 251 (1976).

Bifenazate CAS Registry Number: 149877-41-8 联苯肼酯

CAS Name: 2-(4-Methoxy[1,1'-biphenyl]-3-yl)hydrazinecarboxylic acid 1-methylethyl ester
Additional Names: isopropyl 3-(4-methoxy-3-biphenylyl)carbazateTrademarks: Floramite (Uniroyal)
Percen...
Literature References: Hydrazinecarboxylate miticide for use on fruits and ornamentals. Prepn: M. A. Dekeyser, P. T. McDonald, WO 9310083; eidem, US 5367093 (1993, 1994 both to Uniroyal). Review of physical properties, biological activity, and field trials: M. A. Dekeyser et al., Brighton Crop Prot. Conf. - Pests Dis. 1996, 487-492.

Difluoromethane CAS Registry Number: 75-10-5 二氟甲烷

Additional Names: HFC-32; methylene difluoride; R-32
Trademarks: Genetron 32 (Honeywell)
Percent Composition: C 23.09%, H 3.88%, F 73.04%
Literature References: Hydrofluorocarbon refrigerant with zero ozone-depletion potential. Prepn: A. L. Henne, J. Am. Chem. Soc. 59, 1400 (1937). Structural studies: L. O. Brockway, J. Phys. Chem. 41, 185, 747 (1937); W. C. Hamilton, K. Hedberg, J. Am. Chem. Soc. 75, 5529 (1952). Microwave spectrum: D. R. Lide, Jr., ibid. 74, 3548 (1952). UV absorption spectrum: P. Wagner, A. B. F. Duncan, ibid. 77, 2609 (1955). Thermodynamic properties: P. F. Malbrunot et al., J. Chem. Eng. Data 13, 16 (1968); D. R. Defibaugh et al., ibid. 39, 333 (1994). Viscosity study: M. Takahashi et al., ibid. 40, 900 (1995). Toxicology and metabolism in rats: M. K. Ellis et al., Fundam. Appl. Toxicol. 31, 243 (1996).

Crilanomer CAS Registry Number: 37291-07-9

CAS Name: Starch polymer with 2-propenenitrile
Additional Names: Super-Slurper
Trademarks: Clinagel (Schering); Intrasite (Fisch)
Literature References: Hydrolyzed starch-polyacrylonitile graft copolymers capable of absorbing 2000 times their initial weight of liquid. Prepn: L. A. Gugliemelli et al., J. Appl. Polym. Sci. 13, 2007 (1969). Continuous production: Z. Reyes et al., Ind. Eng. Chem. Process Des. Dev. 12, 62 (1973); manufacturing process: M. O. Weaver et al., Staerke 29, 413 (1977). Analysis: R. J. Dennenberg, T.P. Abbott, J. Polym. Sci. Polym. Lett. Ed. 14, 693 (1976). Use in wound dressings: W. R. Spence, US 4226232 (1980 to Spenco Med). Clinical evaluation in leg ulceration: M. Hornemann, G. Raptis, Z. Hautkrankhr. 62, 41 (1987); B. Esch, G. Raptis, ibid. 64, 1135 (1989). Brief description: H.-G. Elias, Polym. News 4, 26 (1977).

Fenhexamid CAS Registry Number: 126833-17-8 环酰菌胺

CAS Name: N-(2,3-Dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide
Additional Names: 1-methyl-cyclohexanecarboxylic acid (2,3-dichloro-4-hydroxy-phenyl)-amideTrademarks: Decree (Arvesta)...
Literature References: Hydroxyanilide fungicide. Prepn: B.-W. Krüger et al., EP 339418; eidem, US 5059623 (1989, 1991 both to Bayer). Review of properties and activities: H.-J. Rosslenbroich et al., Brighton Crop Prot. Conf. - Pests Dis. 1998, 327-334; of field trials on fruit crops: N. M. Adam, P. A. Birch, ibid., 849-856.