其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Biopterin CAS Registry Number: 22150-76-1 L-生物喋呤

CAS Name: 2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4(1H)-pteridinone
Additional Names: 1-(2-amino-4-hydroxy-6-pteridinyl)-1,2-propanediol; 2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine; pte...
Literature References: A pteridine widely distributed in nature; naturally occurring as the L-erythro-form. Considered as a growth factor for some insects; see also Neopterin. Isoln from human urine: Patterson et al., J. Am. Chem. Soc. 77, 3167 (1955); 78, 5871 (1956); GB 814462 (1959 to Am. Cyanamid); from drosophila: H. S. Forrest, H. K. Mitchell, J. Am. Chem. Soc. 77, 4865 (1955); from queen bee jelly: Butenandt, Rembold, Z. Physiol. Chem. 311, 79 (1958). Absolute configuration: E. L. Patterson et al., J. Am. Chem. Soc. 78, 5871 (1956). Synthesis: E. L. Patterson et al., ibid. 5868; Tschesche et al., Ann. 658, 193 (1962); Rembold, Metzger, Ber. 96, 1395 (1963); Viscontini et al., Helv. Chim. Acta 55, 570, 574 (1972); B. Schircks et al., ibid. 60, 211 (1977); T. Sugimoto et al., Bull. Chem. Soc. Jpn. 53, 2344 (1980). Synthesis from neopterin: A. Kaiser, H. P. Wessel, Helv. Chim. Acta 70, 766 (1987). Biosynthesis: G. Kapatos et al., Science 213, 1129 (1981).

Taka-Diastase CAS Registry Number: 9001-19-8 α-淀粉酶(高温淀粉酶)

CAS Name: a-Amylase (Aspergillus oryzae)
Additional Names: Koji; Aspergillus diastase
Trademarks: Sanzyme (Sankyo)
Literature References: A purified multienzyme produced by the microorganism Aspergillus oryzae (Ahl.) Cohn, Aspergillaceae, grown on sterilized wheat bran or on rice hulls. Represents more than 30 different enzymatic functions. It is not only amylolytic but digests proteins and fats also.

Thymine CAS Registry Number: 65-71-4 胸腺嘧啶

CAS Name: 5-Methyl-2,4(1H,3H)-pyrimidinedione
Additional Names: 5-methyluracil; 2,4-dihydroxy-5-methylpyrimidine
Percent Composition: C 47.62%, H 4.80%, N 22.21%, O 25.37%
Literature References: A pyrimidine derivative; constituent of nucleic acids. Originally isolated from thymus nucleic acid: Levene, Z. Physiol. Chem. 39, 4 (1903). Prepn by heating 2-ethylmercapto-4-hydroxy-5-methylpyrimidine: Wheeler, Merriam, Am. Chem. J. 29, 478 (1903); 43, 29 (1910). From methylcyanacetylurea by catalytic reduction: Bergmann, Johnson, J. Am. Chem. Soc. 55, 1733 (1933). From b-methylmalic acid: Scherp, J. Am. Chem. Soc. 68, 912 (1946). Crystal structure of monohydrate: Gerdil, Acta Crystallogr. 14, 333 (1961). Review: Ts'o, "Bases, Nucleosides and Nucleotides" in Basic Principles in Nucleic Acid Chemistry vol. 1, P. O. P. Ts'o, Ed. (Academic Press, New York, 1974) pp 453-584.

Lanthionine CAS Registry Number: 922-55-4 羊毛硫氨酸

CAS Name: S-[(2R)-2-Amino-2-carboxyethyl]-L-cysteine
Additional Names: 3,3'-thiodi-L-alanine; L-lanthionine; [R-(R*,R*)]-bis(2-amino-2-carboxyethyl)sulfide
Percent Composition: C 34.61%, H 5...
Literature References: A rare amino acid found in proteins; sulfide analog of cystine. First isolated as artifacts of wool hydrolysates. Isoln: M. J. Horn et al., J. Biol. Chem. 138, 141 (1941); from chick embryo: N. H. Sloane, K. G. Untch, Biochemistry 5, 2658 (1966); from silkworm and Japanese oak moth: D. R. Rao et al., ibid. 6, 1208. Synthesis: V. du Vigneaud, G. B. Brown, J. Biol. Chem. 138, 151 (1941). Structure studies: I. W. Stapleton, O. A. Weber, Int. J. Pept. Protein Res. 3, 243 (1971). Crystal structure: G. R. Desiraju, D. R. Rao, Acta Crystallogr. C46, 627 (1990).

g -Carotene CAS Registry Number: 472-93-5 gamma-胡罗卜素

Percent Composition: C 89.49%, H 10.51%
Literature References: A rare carotenoid. Has provitamin A activity. Best source is Penicillium sclerotiorum: Mase et al., Arch. Biochem. Biophys. 68, 150 (1957). Also present in small proportions in many plant materials, esp fruits containing b-carotene. Chromatographic isoln from crude carotenes: Kuhn, Brockmann, Ber. 66, 407 (1933); Winterstein, Z. Physiol. Chem. 219, 249 (1933). Structure: Kuhn, Brockmann, loc. cit.; Naturwissenschaften 21, 44 (1933). Synthesis: Garbers et al., Helv. Chim. Acta 36, 1783 (1953); Ruegg et al., ibid. 44, 985 (1961).

Cinchotoxine CAS Registry Number: 69-24-9 1-(4-喹啉基)-3-[(3R,4R)-3-乙烯基-4-哌啶基]-1-丙酮

CAS Name: (3R-cis)-3-(3-Ethenyl-4-piperidinyl)-1-(4-quinolinyl)-1-propanone
Additional Names: 9-deoxy-9-oxo-1,8-secocinchonine; cinchonicine
Percent Composition: C 77.52%, H 7.53%, N 9.52%, ...
Literature References: A rearrangement product of cinchonine or cinchonidine obtained by boiling with acetic acid: Pasteur, Compt. Rend. 37, 110 (1853). Miller, Rohde, Ber. 33, 3214 (1900). Conversion to cinchonidinone and cinchonine: Rabe, Ber. 44, 2088 (1911); 41, 62 (1908). Prepn from cinchonine: Prostenik, Prelog, Helv. Chim. Acta 26, 1965 (1943).

Metoquinone CAS Registry Number: 622-91-3

Percent Composition: C 67.40%, H 6.79%, N 7.86%, O 17.96%
Literature References: A salt-like compound of 1 mol hydroquinone and 2 mols p-monomethylaminophenol.

Cephradine CAS Registry Number: 38821-53-3 头孢拉定

CAS Name: (6R,7R)-7-[[(2R)-Amino-1,4-cyclohexadien-1-ylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Additional Names: 7-[D-2-amino-2-(1,4-cyclohexadienyl)a...
Literature References: A semisynthetic cephalosporin antibiotic. Prepn and activity data: Weisenborn et al., US 3485819 (1969 to Squibb); Dolfini et al., J. Med. Chem. 14, 117 (1971). Clinical trials: Limson et al., Curr. Ther. Res. 14, 101 (1972); Landa, ibid. 496. Comprehensive description: K. Florey, Anal. Profiles Drug Subs. 5, 21-59 (1976). Review: W. E. Brown, J. R. Knill, in Pharmacological and Biochemical Properties of Drug Substances vol. 2, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1979) pp 279-304.

b -Santalol CAS Registry Number: 77-42-9 [1S-[1Alpha,2A(Z),4Alpha]]-2-甲基5-(2-甲基-3-次甲基二环[2.2.1]庚-2-基)-2-戊烯-1-醇

CAS Name: [1S-[1a,2a(Z),4a]]-2-Methyl-5-(2-methyl-3-methylenebicyclo[2.2.1]hept-2-yl)-2-penten-1-ol
Additional Names: 2-methyl-5-(2-methyl-3-methylene-2-norbornyl)-2-penten-1-ol
Percent Comp...
Literature References: A sesquiterpene alcohol from sandalwood oil. Isoln and purification and additional refs: see a-santalol. Structure: L. Ruzicka, G. Thomann, Helv. Chim. Acta 18, 355 (1935). Synthesis: S. C. Bhattacharyya, Sci. Cult. 13, 209 (1957), C.A. 43, 5385a (1949); H. C. Kretschmar, W. F. Erman, US 3662008, US 3679756 (1972 to Procter Gamble). Natural b-santalol has a cis-(-)-configuration. Total synthesis: eidem, Tetrahedron Lett. 1970, 41. Synthesis of dl-form: P. A. Christenson, B. J. Willis, J. Org. Chem. 44, 2012 (1979); M. Baumann, W. H. Hoffman, Ann. 1979, 743; K. Sato et al., Chem. Lett. 1981, 1183.

a -Santalol CAS Registry Number: 115-71-9 5-(2,3-二甲基三环[2.2.1.02,6]-3-庚基)-2-甲基-2-戊烯-1-醇立体异构体

CAS Name: 5-(2,3-Dimethyltricyclo[2.2.l.02,6]hept-3-yl)-2-methyl-2-penten-1-ol
Percent Composition: C 81.76%, H 10.98%, O 7.26%
Literature References: A sesquiterpene alcohol which together with b-santalol comprises about 90% of commercial sandalwood oil: F. W. Semmler, K. Bode, Ber. 40, 1124 (1907); E. Gruenther, The Essential Oils vol. 2 (Van Nostrand, New York, 1949) pp 266-269. Structure: F. W. Semmler, Ber. 43, 1893 (1910). Separation of a- and b-santalols of high purity: A. E. Bradfield et al., J. Chem. Soc. 1935, 309. Synthesis of a-santalol and conversion to b-santalol: S. C. Bhattacharyya, Sci. Cult. 13, 207 (1947), C.A. 43, 5484gh (1949); see also V. M. Sathe et al., Indian J. Chem. 4, 393 (1966); S. Y. Kamat et al., Tetrahedron 23, 4487 (1967). Stereochemistry studies: G. Brieger, Tetrahedron Lett. 1963, 2123. Natural a-santalol has a cis-(+)-configuration. Total synthesis: R. G. Lewis et al., ibid. 1967, 401. Stereospecific synthesis: E. J. Corey et al., J. Am. Chem. Soc. 92, 226, 6314 (1970); M. Julia, P. Ward, Bull. Soc. Chim. Fr. 1973, 3065; M. Tamura, G. Suzukamo, Tetrahedron Lett. 22, 577 (1981). Synthesis and separation of cis- and trans-isomers: K. Sato et al., Bull. Chem. Soc. Jpn. 49, 3351 (1976). Review: J. Simonsen, D. H. R. Barton, The Terpenes vol. 3 (Univ. Press, Cambridge, 1961) pp 178-188; A. Bhati, Flavour Ind. 1, 235-251 (1970).