其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Phosphorus Pentasulfide CAS Registry Number: 1314-80-3 五硫化二磷

Additional Names: Phosphoric sulfide; thiophosphoric anhydride; phosphorus persulfide
Percent Composition: P 27.87%, S 72.13%
Literature References: Exists as P4S10. Conveniently prepd by fusing red phosphorus with sulfur: Stock, Herscovici, Ber. 43, 1223 (1910); Klement in Handbook of Preparative Inorganic Chemistry vol. 1, G. Brauer, Ed. (Academic Press, New York, 2nd ed., 1963) p 567. Manuf: Faith, Keyes Clark's Industrial Chemicals, F. A. Lowenheim, M. K. Moran, Eds. (Wiley-Interscience, New York, 4th ed., 1975) pp 650-653.

Methyldopa CAS Registry Number: 555-30-6 甲基多巴

CAS Name: 3-Hydroxy-a-methyl-L-tyrosine
Additional Names: L-3-(3,4-dihydroxyphenyl)-2-methylalanine; L-a-methyl-3,4-dihydroxyphenylalanine; L-2-amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic a...
Literature References: Exists as the sesquihydrate. Prepn: Pfister, Stein, US 2868818 (1959 to Merck Co.). Resolution: Jones et al., US 3158648 (1964 to Merck Co.); cf. Slates et al., J. Org. Chem. 29, 1424 (1964). Resolution and configuration: Tristram, ibid. 2053. Synthesis from asymmetric intermediates: Reinhold et al., J. Org. Chem. 33, 1209 (1968). Prepn of the ethyl ester hydrochloride: FR M2153 (1963 to Merck Co.); of pharmaceutical dosage forms: Marcus, US 3230143 (1966 to Merck Co.). Mode of action: Finch, Haeusler, Br. J. Pharmacol. 45, 167p (1972); Day et al., ibid. 168p. Review of pharmacology: A. Scriabine, Ed. in Pharmacology of Antihypertensive Drugs (Raven, New York, 1980) pp 43-54.

Boron Monoxide CAS Registry Number: 12505-77-0

CAS Name: Boron oxide (BO)
Percent Composition: B 40.32%, O 59.68%
Literature References: Exists in multiple polymeric forms, (BO)x. Prepn: E. Zintl et al., Z. Anorg. Allg. Chem. 245, 8 (1940); T. Wartik, E. F. Apple, J. Am. Chem. Soc. 77, 6400 (1955); and proposed structure: A. L. McCloskey et al., ibid. 83, 4750 (1961). VUV absorption spectrum: H. Bredohl et al., Mol. Phys. 101, 2145 (2003).

Angelica Lactone CAS Registry Number: 1333-38-6

CAS Name: 5-Methyl-2-furanone
Percent Composition: C 61.22%, H 6.16%, O 32.62%
Literature References: Exists in three forms. Prepn of a and b-forms: Wolff, Ann. 229, 250 (1885); Thiele, Ann. 319, 184 (1901); v. Auwers, Ber. 56, 1672 (1923); J. H. Helberger et al., Ann. 561, 215 (1949). Prepn of a¢-form: J. P. Wineburg et al., J. Heterocycl. Chem. 12, 749 (1975); V. Jäger, H. J. Günther, Tetrahedron Lett. 1977, 2543; R.A. Amos, J. A. Katzenellenbogen, J. Org. Chem. 43, 560 (1978). Toxicity data for a-form: E. J. Moran et al., Drug Chem. Toxicol. 3, 249 (1980).

Arsenic Acid CAS Registry Number: 7778-39-4 砷酸,原砷酸

Additional Names: Orthoarsenic acid
Percent Composition: As 52.78%, H 2.13%, O 45.09%
Literature References: Exists only as the hemihydrate. Excessive drying produces As2O5.5/3H2O. Conveniently prepd from As2O3 and HNO3: Simon, Thaler, Z. Anorg. Allg. Chem. 161, 143 (1927); 246, 19 (1941). Toxicity study: Joachimoglu, Biochem. Z. 70, 144 (1915). Review of toxicology and human exposure: Toxicological Profile for Arsenic (PB2000-108021, 2000) 468 pp.

Fialuridine CAS Registry Number: 69123-98-4 非阿尿苷

CAS Name: 1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione
Additional Names: 1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodouracil; 5-iodo-2'-fluoroarauracil; FIAU Literature References: Exptl antiviral agent; nucleoside analog with antihepatitis B activity. Prepn: K. A. Watanabe et al., J. Med. Chem. 22, 21 (1979). Antiviral activity: J. M. Colacino, C. Lopez, Antimicrob. Agents Chemother. 24, 505 (1983); K. A. Staschke et al., Antiviral Res. 23, 45 (1994). Clinical pharmacokinetics: R. R. Bowsher et al., Antimicrob. Agents Chemother. 38, 2134 (1994). Report of trial suspension: S. R. Ahmed, Lancet 342, 166 (1993). Evaluation of mechanism of hepatotoxicity: L. Cui et al., J. Clin. Invest. 95, 555 (1995). Clinical toxicological profile: W. Stevenson et al., Transplant. Proc. 27, 1219 (1995).

Erythrophlamine CAS Registry Number: 511-00-2

CAS Name: [1R-(1a,2a,4aa,4bb,7E,8b,8aa,10ab)]-7-[2-[2-(Dimethylamino)ethoxy]-2-oxoethylidene]tetradecahydro-2-hydroxy-1,4a,8-trimethyl-9-oxo-1-phenanthrenecarboxylic acid methyl ester
Percent C...
Literature References: Extracted from the bark of Erythrophleum guineense G. Don., and E. couminga Baillon, Leguminosae. Isoln: Ruzicka et al., Experientia 1, 160 (1945); Engel, Tondeur, Helv. Chim. Acta 32, 2364 (1949). Structure: Mathieson et al., Experientia 16, 404 (1960); Arya, Engel, Helv. Chim. Acta 44, 1650 (1961).

Cassamine CAS Registry Number: 471-71-6 甲基(13Z,14alpha)-13-{2-[2-(二甲基氨基)乙氧基]-2-氧代乙亚基}-14-甲基-7-氧代罗汉松n-16-酸酯

CAS Name: [1S-(1a,4aa,4bb,7E,8b,8aa,10ab)]-7-[2-[2-(Dimethylamino)ethoxy]-2-oxoethylidene]tetradecahydro-1,4a,8-trimethyl-9-oxo-1-phenanthrenecarboxylic acid methyl ester
Additional Names: (E)-...
Literature References: Extracted from the bark of Erythrophleum guineense G. Don., Leguminosae. Isoln: Engel, Tondeur, Helv. Chim. Acta 32, 2364 (1949). Structure: Arya, Engel, ibid. 44, 1650 (1961).

d -Carotene CAS Registry Number: 472-92-4

CAS Name: e,y-Carotene
Percent Composition: C 89.49%, H 10.51%
Literature References: Extracted from the fruit of Gonocaryum pyriforme Mig., Icacinaceae: Winterstein, Z. Physiol. Chem. 219, 249 (1933). Occurs also in carrots and certain varieties of tomatoes. Isoln from tomato mutants: Porter, Murphey, Arch. Biochem. Biophys. 32, 21 (1951). Structure: Kargl, Quackenbush, ibid. 88, 59 (1960). Synthesis: Manchand et al., J. Chem. Soc. 1965, 2019. Absolute configuration: Buchecker, Eugster, Helv. Chim. Acta 54, 327 (1971).

Psoralidin CAS Registry Number: 18642-23-4 补骨脂定

CAS Name: 3,9-Dihydroxy-2-(3-methyl-2-butenyl)-6H-benzofuro[3,2-c][1]benzopyran-6-one
Additional Names: 6-(3-methylbut-2-enyl)coumestrol
Percent Composition: C 71.42%, H 4.79%, O 23.78%
Literature References: Extracted from the seed kernel of Psoralea corylifolia Linn., Leguminosae. Isoln: Chakravarti, J. Sci. Ind. Res. 7B, 24 (1948). Structure: Duttagupta et al., Chem. Ind. (London) 1960, 937. Synthesis: Khastgir et al., Tetrahedron 14, 275 (1961).