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项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Equilenin CAS Registry Number: 517-09-9 马萘雌甾酮

CAS Name: 3-Hydroxyestra-1,3,5,7,9-pentaen-17-one
Additional Names: 11,12,13,14,15,16-hexahydro-3-hydroxy-13-methyl-17H-cyclopenta[a]phenanthren-17-one; 1,3,5:10,6,8-estrapentaen-3-ol-17-one Literature References: Estrogenic steroidal hormone isolated from urine of pregnant mares: Girard et al., Compt. Rend. 195, 981 (1932). Occurs naturally in the d-form. Not found in human urine. Component of Conjugated Estrogenic Hormones, q.v. Isoln by chromatography: Duschinsky, Lederer, Bull. Soc. Chim. Biol. 17, 1534 (1935). Total synthesis: Bachmann et al., J. Am. Chem. Soc. 61, 974 (1939); 62, 824 (1940); Johnson et al., ibid. 67, 2274 (1945); 69, 2942 (1947); 72, 505 (1950); Hughes, Smith, Chem. Ind. (London) 1960, 1022; Bailey et al., Chem. Commun. 1967, 1253; Stein et al., Tetrahedron 26, 1917 (1970). Synthesis from estrone: Corbellini et al., Farmaco Ed. Sci. 19, 913 (1964); O. N. Minailova et al., Zh. Obshch. Khim. 49, 2633 (1979); A. R. Daniewski, T. Kowalczyk-Przewloka, Tetrahedron Lett. 1982, 2411. Review of synthetic studies: Taub, "Naturally Occurring Aromatic Steroids" in The Total Synthesis of Natural Products vol. 2, J. ApSimon, Ed. (John Wiley Sons, New York, 1973) pp 642-663.

Droloxifene CAS Registry Number: 82413-20-5 屈洛昔芬

CAS Name: 3-[(1E)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol
Additional Names: (E)-a-[p-[2-(dimethylamino)ethoxy]phenyl]-a'-ethyl-3-stilbenol; (E)-1-[4'-(2-dimethylaminoeth...
Literature References: Estrogen-receptor antagonist. Prepn: H. Schickaneder et al., EP 54168; eidem, US 5047431 (1982, 1991 both to Klinge); P. C. Ruenitz et al., J. Med. Chem. 25, 1056 (1982). Symposium on pharmacology and clinical studies: Am. J. Clin. Oncol. 14, Suppl. 2, S1-S63 (1991). Clinical trial in breast cancer: P. F. Bruning, Eur. J. Cancer 28A, 1404 (1992).

Gadopentetic Acid CAS Registry Number: 80529-93-7 二亚乙基三胺五乙酸g(III)二氢盐

CAS Name: [N,N-Bis[2-[bis(carboxymethyl)amino]ethyl]glycinato(5-)]gadolinate(2-) dihydrogen
Additional Names: N,N-bis[2-[bis(carboxymethyl)amino]ethyl]glycine gadolinium complex; gadolinium die...
Literature References: Evaluation as water-soluble paramagnetic relaxation reagent (PARR) for NMR spectrometry: J. J. Dechter, G. C. Levy, J. Magn. Reson. 39, 207 (1980); and prepn: T. J. Wenzel et al., Anal. Chem. 54, 615 (1982). Use as diagnostic medium for NMR imaging: H. Gries et al., DE 3129906; eidem, US 4647447 (1983, 1987 both to Schering AG). Physicochemical properties: H. Gries, H. Miklautz, Physiol. Chem. Phys. Med. NMR 16, 105 (1984); E. Roux, L. De Broe, J. Belge Radiol. 71, 31 (1988). Evaluation as NMR contrast-enhancing agent in animals: R. C. Brasch et al., Am. J. Roentgenol. 142, 625 (1984). Pharmacokinetics and toxicity: H. J. Weinmann et al., ibid. 619; in humans: H. J. Weinmann et al., Physiol. Chem. Phys. Med. NMR 16, 167 (1984). HPLC determn: M. M. Vora et al., J. Chromatogr. 369, 187 (1986). Exptl use in imaging reperfused myocardium in dogs: S. Schaefer et al., J. Am. Coll. Cardiol. 12, 1064 (1988). Clinical studies of diagnostic use in brain imaging: R. Felix et al., Radiology 156, 681 (1985); J. P. Stack et al., Neuroradiology 30, 145 (1988). Safety and tolerance in humans: H. A. Goldstein et al., Radiology 174, 17 (1990). Reviews of diagnostic use in intracranial lesions: J. R. Hesselink, G. A. Press, Radiol. Clin. North Am. 26, 873-887 (1988); in spinal disease: G. Sze, ibid. 1009-1024.

Quisqualic Acid CAS Registry Number: 52809-07-1 异喹啉酸(mM/ml)

CAS Name: (aS)-a-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid
Additional Names: L-quisqualic acid; b-(3,5-dioxo-1,2,4-oxodiazolidin-2-yl)-L-alanine
Percent Composition: C 31.75%, H ...
Literature References: Excitatory amino acid (EAA) used to identify a specific subset of EAA receptors; consequently, the receptors are known as quisqualate receptors. See also NMDA, kainic acid. Isoln from the seeds of Quisqualis chinesis and anthelmintic activity: Y.-C. Tuan et al., Yao Hsueh Hsueh Pao 5, 87 (1957), C.A. 56, 14896b (1958); from Q. indica: S.-T. Fang, J.-H. Chu, Hua Hsueh Hsueh Pao 30, 226 (1964), C.A. 61, 7359f (1962); from Q. fructus: T. Takemoto et al., Yakugaku Zasshi 95, 176 (1975), C.A. 82, 152211a (1975). Enzymic synthesis: I. Murakoshi et al., Chem. Pharm. Bull. 22, 473 (1974). Total synthesis: J. E. Baldwin et al., Chem. Commun. 1985, 256. Crystal structure: J. L. Flippen, R. D. Gilardi, Acta Crystallogr. B32, 951 (1976). Identification as a neuroexcitant: H. Shinozaki, I. Shibuya, Neuropharmacology 13, 665 (1974). Receptor binding studies: K. Koshiya, Life Sci. 37, 1373 (1985); J. T. Greenamyre, J. Pharmacol. Exp. Ther. 233, 254 (1985). Review of isolation of quisqualic acid and other EAAs: T. Takemoto, in Kainic Acid as a Tool in Neurobiology, R. G. McGeer et al., Eds. (Raven Press, New York, 1978) pp 1-15.

Domoic Acid CAS Registry Number: 14277-97-5 软骨藻酸

CAS Name: (2S,3S,4S)-2-Carboxy-4-[(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadienyl]-3-pyrrolidineacetic acid
Percent Composition: C 57.87%, H 6.80%, N 4.50%, O 30.83%
Literature References: Excitatory amino acid isolated from the red alga Chondria armata Okamura, Rhodomelaceae, known in Japanese as "domoi". Structural analog of kainic acid, q.v. Shown to be responsible for amnesic shellfish poisoning associated with ingestion of certain cultured blue mussels. Isoln: T. Takemoto, K. Daigo, Chem. Pharm. Bull. 6, 578 (1958); eidem, Arch. Pharm. 293, 627 (1960). Series of articles on isoln, structure, and anthelminthic activity: K. Daigo, Yakugaku Zasshi 79, 350-364 (1959), C.A. 53, 14218 (1959). Structural studies: T. Takemoto et al., ibid. 86, 874 (1966), C.A. 66, 28604m (1967). Total synthesis and revised structure: Y. Ohfune, M. Tomita, J. Am. Chem. Soc. 104, 3511 (1982). Neuroexcitatory activity: T. J. Biscoe et al., Nature 255, 166 (1975); R. Zaczek, J. T. Coyle, Neuropharmacology 21, 15 (1982). Effect on kainate receptor activation: G. Debonnel et al., Can. J. Physiol. Pharmacol. 67, 29, 904 (1989). Identification in toxic mussel extracts: J. L. C. Wright et al., Can. J. Chem. 67, 481 (1989). LC determn in shellfish products: J. F. Lawrence et al., J. Chromatogr. 462, 349, 419 (1989). Reviews: M. A. Quilliam, J. L. C. Wright, Anal. Chem. 61, 1053A-1059A (1989); J. Clayden et al., Tetrahedron 61, 5713-5724 (2005).

Gold Monoxide CAS Registry Number: 1303-57-7

Additional Names: Aurous oxide
Literature References: Existence doubtful; probably a mixture of gold and auric oxide: Pollard, J. Chem. Soc. 129, 1347 (1926). "Au2O" has been prepared by treating K(AuBr2) with alkali.

b -Peltatin CAS Registry Number: 518-29-6 盾叶鬼臼素

CAS Name: [5R-(5a,5ab,8aa)]-5,8,8a,9-Tetrahydro-10-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Additional Names: 8-hydroxy-2-hydroxymethyl-6,7-methylen...
Literature References: Exists as a glucoside in the rhizomes of Podophyllum peltatum L., Berberidaceae: von Wartburg et al., Helv. Chim. Acta 40, 1331 (1957). Isoln from resin podophyllum: Hartwell, Detty, J. Am. Chem. Soc. 70, 2833 (1948); 72, 246 (1950); from Hyptis verticillata Jacq., Labiatae: German, J. Pharm. Sci. 60, 649 (1971).

a -Peltatin CAS Registry Number: 568-53-6 alpha-盾叶鬼臼素

CAS Name: [5R-(5a,5ab,8aa)]-5,8,8a,9-Tetrahydro-10-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Additional Names: 8-hydroxy-2-hydroxymethyl-6,7-m...
Literature References: Exists as a glucoside in the rhizomes of Podophyllum peltatum L., Berberidaceae: von Wartburg et al., Helv. Chim. Acta 40, 1331 (1957). Isoln from resin podophyllum: Hartwell, Detty, J. Am. Chem. Soc. 72, 246 (1950).

Niobium Potassium Oxypentafluoride CAS Registry Number: 17523-77-2

Additional Names: Columbium potassium oxypentafluoride
Percent Composition: F 41.55%, K 24.43%, Nb 29.03%, O 5.00%
Literature References: Exists as monohydrate. Prepn: Hoard, Martin, J. Am. Chem. Soc. 63, 11 (1941).

Reinecke Salt CAS Registry Number: 13573-16-5 利英钠克盐

CAS Name: Ammonium diamminetetrakis(thiocyanato-N)chromate(1-)
Additional Names: ammonium reineckate; ammonium tetrathiocyanodiammonochromate
Percent Composition: C 14.28%, H 3.00%, Cr 15.46...
Literature References: Exists as monohydrate; made by fusing ammonium thiocyanate with ammonium dichromate. Prepn: Dakin, Org. Synth. coll. vol. II, 555 (1943).