其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Alexitol Sodium CAS Registry Number: 66813-51-2 铝西托钠

Additional Names: Sodium polyhydroxyaluminum monocarbonate hexitol complex; aluminum sodium carbonate hexitol complex
Trademarks: Actal (SKB)
Literature References: Description and antacid properties: J. R. Gwilt et al., J. Pharm. Pharmacol. 10, 770 (1958). Stabilization with a hexitol (sorbitol or mannitol): Alford, US 2999790 (1962 to Sterling Drug). Neutralizing capacity: R. E. Barry, J. Ford, Br. Med. J. 1, 413 (1978).

Phenyl Aminosalicylate CAS Registry Number: 133-11-9 非那米柳

CAS Name: 4-Amino-2-hydroxybenzoic acid phenyl ester
Additional Names: p-aminosalicylic acid phenyl ester; phenyl p-aminosalicylic acid; p-aminosalol; fenamisal
Trademarks: Phenyl PAS; Pheny...
Literature References: Description of properties: Meyer, Antibiot. Annu. 1957-1958, 614. Prepd by Raney nickel reduction of the corresp nitro ester in ethyl acetate: Friere, US 2604488 (1952 to Rhône-Poulenc).

Hexazole CAS Registry Number: 4671-03-8 海克沙唑

CAS Name: 4-Cyclohexyl-3-ethyl-4H-1,2,4-triazole
Additional Names: 3-ethyl-4-cyclohexyl-4H-1,2,4-triazole; Azoman; Triazol IngelheimPercent Composition: C 67.00%, H 9.56%, N 23.44%
Literature References: Description: Behrens et al., Klin. Wochenschr. 16, 944 (1937).

Valdetamide CAS Registry Number: 512-48-1 二乙烯丙醋胺

CAS Name: 2,2-Diethyl-4-pentenamide
Additional Names: diethylallylacetamide
Trademarks: Novonal (Hoechst)
Percent Composition: C 69.63%, H 11.04%, N 9.02%, O 10.31%
Literature References: Description: Bockmühl, Schaumann, Dtsch. Med. Wochenschr. 54, 270 (1928). Pharmacokinetics and metabolism: H. Uehleke, M. Brinkschulte-Freitas, Arch. Pharmacol. 302, 11 (1978). TLC determn in urine: E. Klug, P. Toffel, Arzneim.-Forsch. 29, 1651 (1979).

Benziodarone CAS Registry Number: 68-90-6 苯碘达隆

CAS Name: (2-Ethyl-3-benzofuranyl) (4-hydroxy-3,5-diiodophenyl) methanone
Additional Names: 2-ethyl-3-(3',5'-diiodo-4'-hydroxybenzoyl)benzofuran; 2-ethyl-3-(3',5'-diiodo-4'-hydroxybenzoyl)oxain...
Literature References: Description: Charlier, Acta Cardiol. Suppl. 7, 1-60 (1959). Synthesis: Beaudet, Henaux, BE 553621; GB 836272 (1957, 1960, both to Labaz); Buu-Hoi, Beaudet, US 3012042 (1961 to Soc. Belge Azote Prod. Chim. Marly). Clinical trial in hyperuricemia in renal transplant patients: F. Perez-Ruiz et al., Nephrol. Dial. Transplant. 18, 603 (2003).

Tolbutamide CAS Registry Number: 64-77-7 甲苯磺丁脲

CAS Name: N-[(Butylamino)carbonyl]-4-methylbenzenesulfonamide
Additional Names: 1-butyl-3-(p-tolylsulfonyl)urea; tolylsulfonylbutylurea; 3-(p-tolyl-4-sulfonyl)-1-butylurea; N-n-butyl-N'-tosylur...
Literature References: Description: Ehrhart, Naturwissenschaften 43, 93 (1956). Prepn: GB 808071; Aumüller, Herr, DE 1066575 (both 1959 to Hoechst); Ruschig et al., US 2968158 (1961 to Upjohn). Comprehensive description: W. F. Beyer, E. H. Jensen, Anal. Profiles Drug Subs. 3, 513-543 (1974).

Opiniazide CAS Registry Number: 2779-55-7 奥匹烟肼

CAS Name: 4-Pyridinecarboxylic acid [(2-carboxy-3,4-dimethoxyphenyl)methylene]hydrazide
Additional Names: 5,6-dimethoxyphthalaldehydic acid isonicotinoylhydrazone; 1-(2-carboxy-3,4-dimethoxyben...
Literature References: Description: G. N. Pershin, S.A. Vichkanova, C.A. 51, 10747e (1957); C.A. 52, 1485-1486 (1958); V. A. Buskina, C.A. 54, 744f (1960). Bioavailability: A. F. Zaeko, V. G. Perkova, Farmatsiya (Moscow) 28, 28 (1979), C.A. 92, 185805g (1980). Toxicity study: R. A. Akhundov, Mater. Nauchn. Konf. Azgosmedinstituta 1975, 137, C.A. 86, 50678y (1977).

Chloroprocaine Hydrochloride CAS Registry Number: 3858-89-7 盐酸氯普鲁卡因

CAS Name: 4-Amino-2-chlorobenzoic acid 2-(diethylamino)ethyl ester monohydrochloride
Additional Names: 2-chloro-4-aminobenzoic acid diethylaminoethyl ester hydrochloride
Trademarks: Nesacain...
Literature References: Description: Hädicke, Pharm. Zentralhalle 94, 384 (1955).

Garenoxacin CAS Registry Number: 194804-75-6 加雷沙星

CAS Name: 1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acidPercent Composition: C 64.78%, H 4.73%, F 8.91%, N 6.57%, O 1...
Literature References: Des-F(6)-quinolone antibacterial; topoisomerase II inhibitor. Prepn: Y. Todo et al., WO 9729102; eidem, US 6025370 (1997, 2000 both to Toyama); and antibacterial activity: K. Hayashi et al., Arzneim.-Forsch. 52, 903 (2002). HPLC determn in serum: D. Xuan et al., J. Chromatogr. B 765, 37 (2001). Mechanism of action study: D. Ince et al., Antimicrob. Agents Chemother. 46, 3370 (2002). Comparative antimicrobial spectra: M. Takahata et al., ibid. 43, 1077 (1999); M. Bassetti et al., ibid. 46, 234 (2002). Clinical pharmacokinetics: D. A. Gajjar et al., ibid. 47, 2256 (2003); and pharmacodynamics: S. Van Wart et al., ibid. 48, 4766 (2004). Toxicology study: A. Nagai et al., J. Toxicol. Sci. 27, 219 (2002). Review of pharmacology and therapeutic potential: R. Frechette, Curr. Opin. Invest. Drugs 2, 1706-1711 (2001).

Hypoxanthine CAS Registry Number: 68-94-0 次黄嘌呤

CAS Name: 1,7-Dihydro-6H-purin-6-one
Additional Names: purin-6(1H)-one; sarcine; sarkin
Percent Composition: C 44.12%, H 2.96%, N 41.16%, O 11.75%
Literature References: Desmotropic forms: purin-6-ol; 1H-purin-6-ol; 3H-purin-6-ol; 9H-purin-6-ol; purin-6(3H)-one; 9H-purin-6(1H)-one. Formed in the animal body during the breakdown of nucleic acids; formation from adenosine continues after death. Also widely distributed in the vegetable kingdom. Numerous syntheses, e.g., from 2,6,8-trichloropurine: Fischer, Ber. 30, 2226 (1897); by oxidation of adenine: Krüger, Z. Physiol. Chem. 18, 445 (1894). By reduction of uric acid: Sundwik, ibid. 76, 486 (1912); by condensing ethyl cyanoacetate and thiourea in the presence of Na-ethoxide: Traube, Ann. 331, 64 (1904); from mercapto-4-hydroxy-6-aminopyrimidine: Taylor, Cheng. J. Org. Chem. 25, 148 (1960). Reviews: Levene, Bass, ACS Monograph Series no. 56, entitled "Nucleic Acids" (New York, 1931); Chargaff, Davidson, Nucleic Acids vols. I II (Academic Press, New York, 1955).