其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

N-Nitrosodiethylamine CAS Registry Number: 55-18-5 N-二乙基亚硝胺

CAS Name: N-Ethyl-N-nitrosoethanamine
Additional Names: diethylnitrosamine
Trademarks: DEN; DENA; NDEA
Percent Composition: C 47.04%, H 9.87%, N 27.43%, O 15.66%
Literature References: Detected in trace amounts in tobacco smoke: Druckney, Preussman, Naturwissenschaften 49, 498 (1962) and in various processed foods: Hedler, Marquardt, Food Cosmet. Toxicol. 6, 341 (1968); Friemuth, Glaeser, Nahrung 14, 357 (1970). Formed by the interaction of nitrite with diethylamine and by the action of nitrate-reducing bacteria. Industrial prepn: Reilly, DE 1085166 (1960 to du Pont), C.A. 56, 4594h (1962); Levering, Maury, US 3090786 (1963 to Hercules Powder); Minisci, Galli, Chim. Ind. (Milan) 46, 173 (1964). Hepatotoxicity and carcinogenicity studies: Schmaehl et al., Naturwissenschaften 54, 341 (1967); Grover, Fischer, Eur. J. Cancer 7, 77 (1971); Bader et al., Arch. Geschwulstforsch. 37, 327 (1971). General review: Magee, Barnes, Adv. Cancer Res. 10, 163-246 (1967).

Dimercaprol CAS Registry Number: 59-52-9 2,3-二巯基丙醇

CAS Name: 2,3-Dimercapto-1-propanol
Additional Names: 1,2-dithioglycerol; British anti-lewisite; BAL
Trademarks: Dicaptol (Chinoin); Sulfactin (Viatris)
Percent Composition: C 29.00%, H 6...
Literature References: Developed as an antidote to the vesicant warfare agent, dichloro(2-chlorovinyl)arsine, q.v., also known as Lewisite. Inhibits the toxic action of arsenic on pyruvate dehydrogenase. Discovery and development: R. A. Peters et al., Nature 156, 616 (1945); L. L. Waters, C. Stock, Science 102, 601 (1945). Prepn by hydrogenation of hydroxypropylene trisulfide: W. J. Peppel, F. K. Signaigo, US 2402665 (1946 to DuPont). Stereospecific synthesis: A. K. M. Anisuzzaman, L. N. Owen, J. Chem. Soc. C 1967, 1021. GC/MS determn in plasma: C. E. Byers et al., J. Anal. Toxicol. 28, 384 (2004). Toxicity study: P. Zvirblis, R. I. Ellin, Toxicol. Appl. Pharmacol. 36, 297 (1976). Review of discovery, biochemistry and clinical applications: J. A. Vilensky, K. Redman, Ann. Emerg. Med. 41, 378-383 (2003).

Arabitol CAS Registry Number: 2152-56-9 DL-阿拉伯糖醇

CAS Name: Arabinitol
Additional Names: 1,2,3,4,5-pentanepentol; arabite
Percent Composition: C 39.47%, H 7.95%, O 52.58%
Literature References: D-Form obtained by reduction of D-arabinose or D-lyxose with sodium amalgam: Ruff, Ber. 32, 555 (1899); Ruff, Ollendorff, Ber. 33, 1802 (1900); Bertrand, Bull. Soc. Chim. [3] 15, 593 (1896). Production by fermentation from molasses using Saccharomyces rouxii and Saccharomyces mellis: Lavin, Holloway, US 2934474 (1960 to Comm. Solvents). L-Form obtained by reduction of L-arabinose with sodium amalgam: Kiliani, Ber. 20, 1234, 1571 (1887). DL-Form obtained from equal parts of D- and L-arabitol: Ruff, loc. cit. Synthesis: Lespian, Compt. Rend. 206, 1773 (1938).

Dicentrine CAS Registry Number: 517-66-8 D-荷包牡丹碱

CAS Name: 6,7,7a,8-Tetrahydro-10,11-dimethoxy-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline
Additional Names: 9,10-dimethoxy-1,2-(methylenedioxy)aporphine; 1,2-methylenedioxy-9,10-di...
Literature References: d-Form prevalent in nature. Found in Dicentra pusilla Sieb. Zucc., Fumariaceae and several other Dicentra species. Related to actinodaphnine, and laurotetanine, q.q.v. Isoln: Y. Asahina, Arch. Pharm. 247, 201 (1909). Isoln of l-form from Duguetia A. St. Hil., Annonaceae: Casagrande, Ferrari, Farmaco Ed. Sci. 25, 442 (1970). Synthesis of dl-form: Haworth et al., J. Chem. Soc. 127, 2018 (1925); Cava et al., Tetrahedron 29, 2245 (1973). Resolution of isomers: Haworth et al., J. Chem. Soc. 129, 29 (1926).

Glaucine CAS Registry Number: 475-81-0 (+)-海罂粟碱

CAS Name: (6aS)-5,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo[de,g]quinoline
Additional Names: 1,2,9,10-tetramethoxyaporphine; boldine dimethyl ether
Trademarks: Bromcholitin...
Literature References: d-Form prevalent in nature. Found in Glaucium flavum Crantz (G. luteum Scop.), Papaveraceae and in Dicentra and Corydalis species, Fumariaceae. Isoln: Fischer, Arch. Pharm. 239, 426 (1901). Structure and prepn: Gadamer, ibid. 249, 680 (1911); Späth, Tharrer, Ber. 66, 904 (1933). Configuration: Faltis, Adler, Arch. Pharm. 284, 281 (1951). Synthesis of dl-form: Chan, Maitland, J. Chem. Soc. C 1966, 753; Jackson, Martin, ibid. 2061; Cava et al., J. Org. Chem. 35, 175 (1970). Pharmacology and toxicity of dl-glaucine phosphate: Y. Kasé et al., Arzneim.-Forsch. 33, 936 (1983). Sites of antitussive action: eidem, ibid. 947.

Diacerein CAS Registry Number: 13739-02-1 双醋瑞因; 二乙酰大黄酸; 二乙酰二氢蒽羧酸

CAS Name: 4,5-Bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid
Additional Names: 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroic acid diacetate; 1,8-diacetoxy-3-carboxyanthra...
Literature References: Diacetyl derivative of rhein, q.v. Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Prepn: A. Tschirch, K. Heuberger, Arch. Pharm. 240, 596 (1902); V. K. Murty et al., Tetrahedron 23, 515 (1967). Effect on prostaglandin release: P. Pomarelli et al., Farmaco Ed. Sci. 35, 836 (1980). Inhibition of proteases: L. Raimondi et al., Pharmacol. Res. Commun. 14, 103 (1982). Use in arthritis: C. A. Friedmann, DE 2711493; idem, US 4244968 (1977, 1981 both to Proter). Preliminary clinical study in osteoarthritis: A. G. Kay et al., Curr. Med. Res. Opin. 6, 548 (1980). Use in multiple sclerosis, amyotrophic lateral sclerosis: C. A. Friedmann, US 4346103 (1982); idem, JP Kokai 83 225015 (1983 to Proter), C.A. 100, 144991e (1984). Clinical trial in osteoarthritis: S. Adami et al., Clin. Ter. 112, 439 (1985).

Chromafenozide CAS Registry Number: 143807-66-3 2'-叔丁基-5-甲基-2'-(3,5-二甲基苯甲酰基)色满-6-甲酰肼

CAS Name: 3,4-Dihydro-5-methyl-2H-1-benzopyran-6-carboxylic acid 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl)hydrazide
Additional Names: 2'-tert-butyl-5-methyl-2'-(3,5-xyloyl)chromane-6-carboh...
Literature References: Diacylhydrazine ecdysone mimetic for use in food crops. Prepn: M. Yanagi et al., EP 496342; eidem, US 5378726 (1992, 1995 both to Nippon Kayaku; Sankyo). Properties and biological activity: M. Yanagi et al., BCPC Conf. - Pests Dis. 2000, 27. Field trial against apple tortix: R. Ichinose et al., Annu. Rep. Sankyo Res. Lab. 52, 59 (2000). Mode of action: T. Toya et al., Biochem. Biophys. Res. Commun. 292, 1087 (2002). Series of articles on design, synthesis, and activity: Y. Sawada et al., Pest Manage. Sci. 59, 25-57 (2003). Review of development, environmental chemistry, safety, and toxicity: K. Tanaka et al., Annu. Rep. Sankyo Res. Lab. 53, 1-49 (2001).

DEHP CAS Registry Number: 117-81-7 邻苯二甲酸二辛酯

CAS Name: 1,2-Benzenedicarboxylic acid bis(2-ethylhexyl) ester
Additional Names: bis(2-ethylhexyl) phthalate; di(2-ethylhexyl) phthalate; DOP; dioctyl phthalate
Trademarks: Octoil
Percent...
Literature References: Dialkyl phthalate ester plasticizer used to impart softness and flexiblilty to PVC products. Prepn: P. J. Garner, G. Watson, US 2508911 (1950 to Shell). Effect on dynamic mechanical properties: D. L. Hertz, Jr., Elastomerics 116, 20 (1984); interaction with PVC polymer: B. Garnaik, S. Sivaram, Macromolecules 29, 185 (1996). HPLC determn in PVC packaging: M. F. Aignasse et al., Int. J. Pharm. 113, 241 (1995). GC/MS determn in toys: R. Stringer et al., Environ. Sci. Pollut. Res. Int. 7, 27 (2000). Evaluation of carcinogenic risk: J. Doull et al., Regul. Toxicol. Pharmacol. 29, 327 (1999); of health effects: M. Fay et al., Toxicol. Ind. Health 15, 651 (1999). Review: L. G. Krauskopf, Plast. Compd. 6, 28-38 (1983). Review of environmental fate: C. A. Staples et al., Chemosphere 35, 667-749 (1997); of aquatic toxicity: idem et al., Environ. Toxicol. Chem. 16, 875 (1997); of toxicology and human exposure: Toxicological Profile for Di(2-ethylhexyl)phthalate (PB2003-100138, 2002) 337 pp.

DINP CAS Registry Number: 28553-12-0 邻苯二甲酸二异壬酯

CAS Name: 1,2-Benzenedicarboxylic acid diisononyl ester
Additional Names: diisononyl phthalate
Percent Composition: C 74.60%, H 10.11%, O 15.29%
Literature References: Dialkyl phthalate ester plasticizer used to impart softness and flexiblilty to PVC products. Prepn: P. J. Garner, G. Watson, US 2508911 (1950 to Shell). Effects on behavior and properties of PVC: S. V. Patel, M. Gilbert, Plast. Rubber Process. Appl. 6, 321 (1986); eidem, ibid. 8, 215 (1987). Effects of temperature on viscosity and density: L. D. Lorenzi et al., J. Chem. Eng. Data 43, 183 (1998). GC/MS determn in toys: R. Stringer et al., Environ. Sci. Pollut. Res. Int. 7, 27 (2000). Review: L. G. Krauskopf, Plast. Compd. 6, 28-38 (1983). Review of environmental fate: C. A. Staples et al., Chemosphere 35, 667-749 (1997). Review of health effects and risk assessment: C. F. Wilkinson, J. C. Lamb, Regul. Toxicol. Pharmacol. 30, 140-155 (1999); and environmental fate and toxicology: U. S. Gill et al., Rev. Environ. Contam. Toxicol. 172, 87-127 (2001).

Mitolactol CAS Registry Number: 10318-26-0 二溴甘露醇

CAS Name: 1,6-Dibromo-1,6-dideoxygalactitol
Additional Names: 1,6-dibromo-1,6-dideoxydulcitol; dibromodulcitol; dibromodulcit; DBDTrademarks: Elobromol (Chinoin)
Percent Composition: C 23.40...
Literature References: Diastereoisomer of mitobronitol, q.v., with myelosuppressive effects. Prepn and anticancer activity: NL 6600395; P. Horváth-Lengyel et al., US 3993781 (1966, 1976 both to Chinoin); B. Kellner et al., Nature 213, 402 (1967). Structure-activity correlations: L. Institoris et al., Arzneim.-Forsch. 17, 145 (1967). Pharmacological study: T. H. Corbett et al., Cancer 40, Suppl. 5, 2660 (1977). Metabolism, pharmacokinetics: I. P. Horváth et al., Eur. J. Cancer 15, 337 (1979). Clinical studies: W. Medina, J. M. Kirkwood, Cancer Treat. Rep. 66, 195 (1982); D. C. Tormey et al., Am. J. Clin. Oncol. 5, 33 (1982).