CAS: 846023-56-1; 2-Cyano-N-(2,4-Dichloro-5-Methoxyphenyl)-3-((4-Methoxy-3-(3-(4-Methylpiperazin-1-yl)Propoxy)Phenyl)Amino)Acrylamide

上下游产品

2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide 4-methoxy-3-[3-(4-methylpiperazin-1-yl)propoxy]phenylamine orthoformic acid triethyl ester 1-(2-methoxy-5-nitrophenoxy)-3-chloropropane

📜2-(3-氯丙氧基)-1-甲氧基-4-硝基苯置于palladium On Activated Charcoal,氢气,原甲酸三乙酯,Sodium Iodide体系中,用 乙二醇二甲醚,异丙醇 作为反应溶剂,化学反应生成 2-氰基-N-(2,4-二氯-5-甲氧基苯基)-3-{4-甲氧基-3-[3-(4-甲基哌嗪-1-基)-丙氧基]-苯基氨基}-丙烯酰胺
参考文献:A Robust,Streamlined Approach To Bosutinib Monohydrate
标题:A Robust,Streamlined Approach To Bosutinib Monohydrate
摘要:This Article Describes A Systematic Approach Used To Streamline The Process For The Isolation Of Bosutinib Monohydrate,A Promiscuous Solvate Former. A Thorough Understanding Of The Complex Solid Form Landscape Was Garnered,And This Knowledge Was Used To Develop A Process That Routinely Delivered The Correct Solid Form And Excellent Purity At The End Of The Last Bond-Formation Step,Without The Need For Additional Recrystallization And/or Solid Form Conversion Steps.
DOI:10.1021/op300087R