CAS: 67469-78-7; 1-(2-(Bis(4-Fluorophenyl)Methoxy)Ethyl)-4-(3-Phenylpropyl)Piperazine Dihydrochloride

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上下游产品

CAS号637-59-2 1-溴-3-苯基丙烷 | CAS号61897-33-4 1-[2-[bis(4-flu... | CAS号67469-69-6 伐诺司林 | CAS号55455-92-0 苯基丙基哌嗪 | CAS号365-24-2 4,4'-二氟二苯甲醇 | CAS号50366-31-9 1-[2-chloroetho...

合成工艺路线路线简述

  • 合成目标产物 Vanoxerine Dihydrochloride 主要起始原料 1-Bromo-3-Phenylpropane
  • (文献来源)合成步骤主要原料 1-Bromo-3-Phenylpropane

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专利信息


专利号:US-9486471-B2
优先权日:2012-03-28
标题:Combination therapy for the treatment of cancer
发明人：BHATIA MICKIE; SACHLOS ELEFTHERIOS
权利人:UNIV MCMASTER
摘要:Described are methods and compositions for treating cancer that include a dopamine receptor (DR) antagonist such as thioridazine and a chemotherapeutic agent. Optionally, the chemotherapeutic agent is a DNA synthesis inhibitor such as cytarabine or a microtubule inhibitor such as paclitaxel or docetaxel. The methods and compositions are useful for the treatment of cancers such as acute myeloid leukemia.

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主要参考文献


1: Lane EL, Cheetham S, Jenner P. Dopamine uptake inhibitor-induced rotation in 6-hydroxydopamine-lesioned rats involves both D1 and D2 receptors but is modulated through 5-hydroxytryptamine and noradrenaline receptors. J Pharmacol Exp Ther. 2005 Mar;312(3):1124-31. Japanese. Japanese.

合成参考文献


参考文献:10.1038/s41380-021-01194-y
摘要:Korn C, Akam T, Jensen KHR, Vagnoni C, Huber A, Tunbridge EM, Walton ME. Distinct roles for dopamine clearance mechanisms in regulating behavioral flexibility. Molecular Psychiatry. 2021 Jun 30;26(12):7188–99. doi: 10.1038/s41380-021-01194-y.
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