CAS: 6168-72-5; 2-Aminopropan-1-Ol

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CAS号2902-96-7 2-硝基-1-丙醇 | CAS号116-09-6 羟基丙酮 | CAS号302-72-7 DL-2-氨基丙酸 | CAS号56-81-5 甘油 | CAS号17344-99-9 2-amino-propion... | CAS号120586-56-3 Propanoic acid,... | CAS号7476-61-1 3-chloro-2-meth... | CAS号107-10-8 丙胺 | CAS号1188-01-8 DL-丙氨酰甘氨酸 | CAS号1437-89-4 2-巯基-4-甲基-2-噻唑啉 | CAS号2749-11-3 L-氨基丙醇 | CAS号35320-23-1 D-氨基丙醇 | CAS号1492-24-6 L-2-氨基丁酸 | CAS号116-09-6 羟基丙酮 | CAS号302-72-7 DL-2-氨基丙酸 | CAS号4744-12-1 2-aminopropanal | CAS号302-84-1 DL-丝氨酸 | CAS号56-40-6 甘氨酸 | CAS号3042-21-5 2-Phenyl-5-meth...

2-硝基-1-丙醇置于三氯硅烷,N,N-二异丙基乙胺体系中,用 乙腈 作为反应溶剂,化学反应 18.0H,以90%的收率获得产物dl-氨基丙醇
参考文献:芳香族和脂肪族硝基化合物无金属还原成胺:Hsicl 3介导的反应,具有广泛的通用性
标题:芳香族和脂肪族硝基化合物无金属还原成胺:Hsicl 3介导的反应,具有广泛的通用性
摘要:报道了一种新的,温和的,不含金属的,Hsicl 3介导的将芳族和脂肪族硝基均还原为胺的方法,该方法具有广泛的通用性,可耐受许多官能团,并尊重立体中心的立体化学完整性.
DOI:10.1021/acs.Orglett.5B01698

专利信息

专利号:US-6133018-A
优先权日:1997-06-02
标 题 :Enzymatic synthesis of chiral amines using -2-amino propane as amine donor
发明人：WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE L; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

专利号:US-10040752-B2
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
发明人：MKRTCHYAN GNEL; YAO QINGWEI
权利人:CODY LABORATORIES INC
摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

专利号:EP-1075534-B8
优先权日:1998-03-11
标 题 :Improvements in the enzymatic synthesis of chiral amines
发明人：WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

专利号:US-9777027-B2
优先权日:2013-10-25
标 题 :Method for the synthesis of ethane-1-hydroxy-1,1-diphosphonic acid
发明人：NOTTÉ PATRICK PIERRE; COGELS SAMUEL
权利人:STRAITMARK HOLDING AG
摘要:The present invention is related to a method for the synthesis of ethane-1-hydroxy-1,1-diphosphonic acid or its salt which includes the steps of reacting tetraphosphorus hexaoxide and acetic acid under controlled reaction conditions; hydrolyzing the formed ethane-1-hydroxy-1,1-diphosphonic acid condensates to form ethane-1-hydroxy-1,1-diphosphonic acid; further processing the ethane-1-hydroxy-1,1-diphosphonic acid solution. The process according to the method of the present invention is highly controllable and further is characterized by a high selectivity.

专利号:WO-2015130660-A1
优先权日:2014-02-25
标题 :Synthesis of racemic amphetamine derivatives by cuprate addition reaction with aziridine phosphoramidate compounds
发明人：MECKLER HAROLD; GREGG BRIAN THOMAS; YANG JIE
权利人:Chemapotheca LLC
摘要:The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.

专利号:US-9321794-B2
优先权日:2013-12-31
标题:Synthesis of racemic amphetamine derivatives by cuprate addition reaction with aziridine phosphoramidate compounds
发明人：MECKLER HAROLD; GREGG BRIAN THOMAS; YANG JIE
权利人:Chemapotheca LLC
摘要:The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.