CAS: 55447-00-2; (S)-2-((Tert-Butoxycarbonyl)Amino)-3-(Naphthalen-1-yl)Propanoic Acid

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76932-48-4 104882-22-6 138774-93-3

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CAS号24424-99-5 二碳酸二叔丁酯 | CAS号55516-54-6 3-(1-萘基)-L-丙氨酸 | CAS号109-02-4 N-甲基吗啉 | CAS号1122-58-3 4-二甲氨基吡啶 | CAS号5440-57-3 Propanedioicaci...

(2S)-2-<(Tert-Butoxycarbonyl)Amino>-1-<(Tert-Butyldimethylsilyl)Oxy>-3-(1-Naphthyl)Propane置于重铬酸吡啶,四丁基氟化铵体系中,用 四氢呋喃,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 25.0H,反应生成 Boc-3-(1-萘基)-L-丙氨酸
参考文献:Synthesis Of N-Boc-β-Aryl Alanines And Of N-Boc-β-Methyl-β-Aryl Alanines By Regioselective Ring-Opening Of Enantiomerically Pure N-Boc-Aziridines
标题:Synthesis Of N-Boc-β-Aryl Alanines And Of N-Boc-β-Methyl-β-Aryl Alanines By Regioselective Ring-Opening Of Enantiomerically Pure N-Boc-Aziridines
摘要:
DOI:10.1021/jo981140I

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-8378099-B2
优先权日:1994-10-28
标 题:Boronic ester and acid compounds, synthesis and uses
发明人：ADAMS JULIAN; MA YU-TING; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS
权利人:MILLENNIUM PHARMACUETICALS INC; ADAMS JULIAN; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS
摘要:Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.

专利号:US-10906033-B2
优先权日:2016-03-28
标题 :Synthesis and application of chiral substituted polyvinylpyrrolidinones
发明人：HUA DUY H
权利人:UNIV KANSAS STATE
摘要:Chiral polyvinylpyrrolidinone (CSPVP), complexes of CSPVP with a core species, such as a metallic nanocluster catalyst, and enantioselective oxidation reactions utilizing such complexes are disclosed. The CSPVP complexes can be used in asymmetric oxidation of diols, enantioselective oxidation of alkenes, and carbon-carbon bond forming reactions, for example. The CSPVP can also be complexed with biomolecules such as proteins, DNA, and RNA, and used as nanocarriers for siRNA or dsRNA delivery.

专利号:US-8273403-B2
优先权日:2002-05-10
标题 :Generation of surface coating diversity
发明人：BARDEN MICHAEL C; KAMBOURIS PETER A
权利人:BARDEN MICHAEL C; KAMBOURIS PETER A; BIO LAYER PTY LTD
摘要:This invention relates to a surface discovery system and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. The system is built upon a synthon which comprises at least three elements: a chemical backbone coating on the solid substrate that comprises a copolymer (B) of at least one passive constituent (P) and at least one active constituent (A); a spacer unit (S) separating the backbone from a functional group; and a functional group (F). The methods comprise the following steps: 1) selecting a plurality of synthons so that each synthon has at least two points of diversity selected from P, A, S and F; 2) applying copolymer B onto a substrate; and 3) attaching a combination of S and F to constituent A of copolymer B. Steps 2) and 3) are performed such that different synthons are generated on localized regions of the substrate.

专利号:US-5378690-A
优先权日:1986-12-19
标题 :New renin-inhibitory oligopeptides, their preparation and their use
发明人：MORISAWA YASUHIRO; KATAOKA MITSURU; YABE YUICHIRO; IIJIMA YASUTERU; TAKAHAGI HIDEKUNI; KOIKE HIROYUKI; KOKUBU TATSUO; HIWADA KUNIO
权利人:SANKYO CO
摘要:Oligopeptides of formula (I): (I) where R1-R5 are various organic groups, and A represents a group of formula -NH- or -(CH2)n-, in which n represents an integer of from 1 to 3, have renin-inhibitory activity and are particularly suitable for oral administration. They may be prepared by condensing their component amino acids or lower oligopeptides using conventional peptide synthesis reactions.

专利号:US-2020306737-A1
优先权日:2016-03-28
标 题:Synthesis and application of chiral substituted polyvinylpyrrolidinones