CAS: 533939-05-8; 6-Ethyl-N,N-Dimethyl-1H-Pyrrolo[2,3-B]Pyridine-3-Methanamine

相似化合物

5654-92-2 7546-48-7 1029512-05-7

上下游产品

CAS号533939-04-7 6-乙基-1H-吡咯并[2,3-b]吡啶 | CAS号68-12-2 N,N-二甲基甲酰胺

📜6-乙基-1H-吡咯并[2,3-B]吡啶,N,N-二甲基甲酰胺 以 乙醇,水 作为反应溶剂,以8.22 G的收率获得产物6-乙基-N,N-二甲基-1H-吡咯并[2,3-B]吡啶-3-甲胺
参考文献:发现[3-(4,5,7-三氟-苯并噻唑-2-基甲基)-吡咯并[2,3-B]吡啶-1-基]乙酸作为治疗醛固酮还原酶的强效选择性抑制剂糖尿病并发症
标题:发现[3-(4,5,7-三氟-苯并噻唑-2-基甲基)-吡咯并[2,3-B]吡啶-1-基]乙酸作为治疗醛固酮还原酶的强效选择性抑制剂糖尿病并发症
摘要:确定慢性糖尿病并发症的治疗方法的努力导致发现了一系列新的高效和选择性的[3-(4,5,7-三氟-苯并噻唑-2-基甲基)-吡咯并[2,3-B]吡啶-1-基]乙酸醛糖还原酶抑制剂.主要候选化合物[6-甲基-3-(4,5,7-三氟-苯并噻唑-2-基甲基)-吡咯并[2,3-B]吡啶-1-基]乙酸实例16,抑制醛糖还原酶ic50为8 Nm,而对醛还原酶(ic50> 100μm)无活性,醛还原酶是一种与活性醛解毒有关的相关酶.
DOI:10.1016/j.Bmcl.2009.02.037

专利信息

专利号:US-7361671-B2
优先权日:2001-11-15
标 题 :Substituted heteroarylalkanoic acids
发明人：VAN ZANDT MICHAEL C; GERACI LEO
权利人:INST PHARMACEUTICAL DISCOVERY
摘要:Disclosed are substituted heteroarylalkanoic acids acids of the following formula D-A-C(O)R′, where D, A, and R′ are defined herein. These compounds are useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.