CAS: 511-45-5; Pridinol

英文名称Pridinol
中文名称二苯帕诺
IUPAC名称1-Piperidinepropanol, alpha,alpha-diphenyl-
其它别名1,1-Diphenyl-3-(1-piperidyl)-1-propanol; 1,1-Diphenyl-3-piperidino-1-propanol; 3-(N-Piperidyl)-1,1-diphenyl-1-propanol; 3-Piperidino-1,1-diphenyl-1-propanol; Benzhydrol, a-(2-piperidinoethyl)-; Nonplesin; ParKS 12 Hommel; Parks; Pridinol; a,a-Diphenyl-1-piperidinepropanol
CAS编号511-45-5
MFCD编号:MFCD00242961
EINECS号:208-128-0
FDA UNII编号:AQ4K0AJT6G
分子式:C20H25NO分子量:295.4186
产品CID: 1500434
同类组份化合物CAS968-58-1 (HCl)511-45-5 (free base)6856-31-1 (mesylate)
产品分类有机原料 → 醇、酚、酚醇类化合物及衍生物

相似结构搜索
InChIKey: RQXCLMGKHJWMOA-UHFFFAOYSA-N
1S/C20H25NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1-2,4-7,10-13,22H,3,8-9,14-17H2
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数5.0

物理性质

熔点120-121°
沸点460.9 °C at 760 mmHg
闪点229.9 °C
密度1.079 g/cm3
pKa:13.49±0.29(预测)
PSA:23.47
LogP:3.7364
蒸汽压5.10X10-9 mm Hg at 25 °C (est)
溶解性In water, 33 mg/L at 25 °C (est)
外观形态固体-粉末
储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

MSDS等安全信息

上下游产品

CAS号1932-03-2 1-(2-氯乙基)哌啶 | CAS号119-61-9 二苯甲酮 | CAS号144-11-6 苯海索 | CAS号13150-57-7 脱水盐酸普地洛尔

合成工艺路线路线简述

合成目标产物 Pridinol 主要起始原料 Methyl 3-(Piperidin-1-yl)Propanoate And Phenylmagnesium Bromide
(文献来源)合成步骤主要原料 Methyl 3-(Piperidin-1-yl)Propanoate 和 Phenylmagnesium Bromide

📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于水体系中,化学反应生成二苯帕诺
参考文献:The Cleavage Of 3-Dimethylamino-1,1-Diphenylbutyl Ethyl Sulfone
标题:The Cleavage Of 3-Dimethylamino-1,1-Diphenylbutyl Ethyl Sulfone
摘要:
DOI:10.1021/ja01148A501

海关参考信息

2902600000-乙苯
2905121000-正丙醇
2906210000-苄醇
2921199090-其他无环单胺
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:WO-2022090277-A1
优先权日:2020-10-30
标题:N-functionalized fatty acid amides as self-tanning substances
发明人：OSTHOFF JULIAN; VON HAGEN JOERG; CAROLA CHRISTOPHE
权利人:MERCK PATENT GMBH
摘要:The present invention relates to the use of N-functionalized fatty acid amides of formula I as self-tanning substances for skin, for stimulating melanin synthesis, for improving melanin transport, for boosting natural tanning and/or improving the distribution of melanin in suprabasal layers of the skin, and to preparations comprising these amides.

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

1: Lauricella L, Calabrese N, Scaturro D, Migliorino D, Vecchio M, Letizia Mauro G. Effectiveness rehabilitative therapy and Pridinol Mesylate in low back pain. Front Med (Lausanne). 2025 Jan 22;11:1470996. doi: 10.3389/fmed.2024.1470996.
2: Rodríguez-Basso ÁG, Bonafede SL, Prado HJ. Concurrent Determination of Pridinol, Diclofenac and Impurity A by HPLC-UV. J Chromatogr Sci. 2023 Dec 30;62(1):92-99. doi: 10.1093/chromsci/bmad017. 13(e3):e945-e947. doi: 10.1136/spcare-2022-003821. 38(7):1203-1217. doi: 10.1080/03007995.2022.2077579. Epub 2022 Jun 1. 38(7):1141-1151. doi: 10.1080/03007995.2022.2072089. Epub 2022 May 23. 59(6):471-477. doi: 10.5414/CP203900.
7: Salazar-Rojas D, Intilangelo A, Vignaduzzo SE, Maggio RM. Development and validation of a green method for dissolution monitoring of pharmaceutical combinations. Meloxican and pridinol. J Pharm Biomed Anal. 2019 Jun 5;170:228-233. doi: 10.1016/j.jpba.2019.03.038. Epub 2019 Mar 18. 74(Pt 3):304-310. doi: 10.1107/S2052520618007023. Epub 2018 May 23.