CAS: 50402-56-7; 5-((2-Aminoethyl)Amino)Naphthalene-1-Sulfonic Acid

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4272-77-9 100900-07-0 36930-63-9

上下游产品

6-Hydroxy-2-naphthalene sulfonic acid sodium salt ethylenediamine 3,6-dimethyl-1,2,4,5-tetrazine 2-(6-methyl-1,2,4,5-tetrazin-3-yl)acetic acid B°C-Glu(EDANS)-OBzl 5-((2-(4-azidobenzamido)ethyl)amino)naphthalene-1-sulfonic acid 4-(3-methoxy-4-{[2-(5-sulfo-naphthalen-1-ylamino)-ethylamino]-methyl}-phenoxy)-butyric acid

📜在 N,N-二异丙基乙胺体系中,用 Aq. Phosphate Buffer,二甲基亚砜,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 4.0H,反应生成,5-(2-氨基乙基氨基)-1-萘磺酸
参考文献:荧光双功能反式环辛烯作为研究点击释放动力学的有效工具.
标题:荧光双功能反式环辛烯作为研究点击释放动力学的有效工具.
摘要:四嗪和烯丙基取代的反式环辛烯(tco)之间的逆电子需求狄尔斯-阿尔德哒嗪消除反应是生物正交键断裂反应的关键参与者.迄今为止,确定烷基胺底物的消除率很困难.在这里,我们报告了一种由 Tco 连接的 Edans 荧光团和 Dabcyl 猝灭剂组成的荧光工具,用于准确测定任何四嗪在生理相关浓度下的点击和释放速率常数.
DOI:10.1002/chem.201905446

专利信息

专利号:US-6451543-B1
优先权日:1998-08-31
标题:Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
发明人：KOCHENDOERFER GERD G; HUNTER CHRISTIE L; KENT STEPHEN B H; BOTTI PAOLO
权利人:GRYPHON SCIENCES
摘要:The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis. The methods and compositions of the invention have multiple uses. For example, they can be used to assay ligand binding to membrane polypeptides and domains comprising a receptor, and thus are extremely useful for structure/function studies, drug screening/selection/design, and diagnostics and the like, including high-throughput applications. The methods and compositions of the invention are particularly suited for FRET analyses of previously inaccessible membrane polypeptides.

专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2023159450-A1
优先权日:2020-05-08
标 题 :Dimers for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; ALTITI AHMAD
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.

专利号:US-9365607-B1
优先权日:2012-07-31
标题 :Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites, and oligonucleotides
发明人：SRIVASTAVA SURESH C; YASKO AMY
权利人:ASED LLC
摘要:The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.

专利号:US-6175020-B1
优先权日:1999-04-09
标题 :Spirodiamino acid scaffold for combinatorial synthesis
发明人：DOLLE III ROLAND ELLWOOD; BARDEN MICHAEL C
权利人:PHARMACOPEIA INC
摘要:Azaspirononanes of formula I and their synthesis n are disclosed. The compounds are useful as templates for constructing synthetic receptors and as intermediates in the synthesis of enzyme inhibitors. They are prepared by an intramolecular ylide cycloaddition of a 6-hydrazone of 2,10-undecadienoic acid ester.

专利号:US-7541165-B2
优先权日:2001-10-30
标 题 :Molecular detection systems utilizing reiterative oligonucleotide synthesis
发明人：HANNA MICHELLE M
权利人:RIBOMED BIOTECHNOLOGIES INC
摘要:The present invention provides methods for detecting the presence of a target molecule by generating multiple detectable oligonucleotides through reiterative enzymatic oligonucleotide synthesis events on a defined polynucleotide sequence. The methods generally comprise using a nucleoside, a mononucleotide, an oligonucleotide, or a polynucleotide, or analog thereof, to initiate synthesis of an oligonucleotide product that is substantially complementary to a target site on the defined polynucleotide sequence; optionally using nucleotides or nucleotide analogs as oligonucleotide chain elongators; using a chain terminator to terminate the polymerization reaction; and detecting multiple oligonucleotide products that have been synthesized by the polymerase. In one aspect, the invention provides a method for detecting a target protein, DNA or RNA by generating multiple detectable RNA oligoribonucleotides by abortive transcription.