CAS: 5001-32-1; 2-(2-(2,6-Dichlorophenoxy)Ethyl)Hydrazinecarboximidamide

该化合物是一种化学化合物,具有一种与二氯苯氧乙基乙基酸相联系的氢氨基氨基胺功能组,其特征是其氢氨结构,其典型的特性表现为具有各种有机合成和生物活动的潜在前体等特性;2,6-二氯苯氧基组的存在表明,它可能具有甲草胺或杀虫特性,因为氯化苯氧化合物往往与这些用途有关;该化合物还可能由于存在水生生物功能组,在极地溶剂中表现出中等至高溶性;此外,其结构表明潜在的再活动性,特别是在核分裂生物替代反应方面,这些反应可在合成化学中加以利用;应当注意安全和处理预防措施,因为含有氢氨衍生物的化合物可能具有毒性和潜在致癌性.

结构式图片

MSDS等安全信息

    上下游产品

    CAS号26583-73-3 2-(2-溴乙氧基)-1,3-二氯苯 | CAS号2347-81-1 2-(2,6-二氯苯氧基)乙基肼 | CAS号867-44-7 |S|-甲基异硫脲硫酸盐 | CAS号14527-26-5 S-甲基异硫脲硫酸盐

    合成工艺路线路线简述

      📜2-(2-溴乙氧基)-1,3-二氯苯置于一水合肼体系中,用 乙醇,水 作为反应溶剂,化学反应 2.0H,反应生成 胍氯酚
      参考文献:某些单取代氨基酸的合成,结构证明和生物活性.
      标题:某些单取代氨基酸的合成,结构证明和生物活性.
      摘要:
      DOI:10.1021/jm00327A029

      海关参考信息

      专利信息


      专利号:US-10925977-B2
      优先权日:2006-10-05
      标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
      发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
      权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
      摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

      专利号:KR-101513003-B1
      优先权日:2006-10-05
      标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy compositions and applications

      专利号:US-10814013-B2
      优先权日:2006-10-05
      标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

      专利号:US-4656291-A
      优先权日:1985-03-15
      标 题 :Process for producing amidine sulfonic acids
      发明人:MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
      权利人:MCNEILAB INC
      摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

      专利号:US-4781866-A
      优先权日:1985-03-15
      标题 :Process for producing amidine sulfonic acid intermediates for guanidines
      发明人:MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
      权利人:MCNEILAB INC
      摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

      专利号:AU-2007308022-A2
      优先权日:2006-10-05
      标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

      供应商参考报价(招募中)

      品牌试剂参考报价(招募中)

      📌 第三方产品分析报告

      ✅ COA系统入驻 | 共享模式

      主要参考文献


      1: SINNIAH R, GATENBY PB. CLINICOPHARMACOLOGICAL ASSESSMENT OF THE NEW ANTI-HYPERTENSIVE COMPOUND GUANOCLOR (VATENSOL). Ir J Med Sci. 1965 Mar;471:111-24.
      3: Mackinnon J, el-Baz LM. A comparison of guanoclor and methyldopa in the treatment of severe hypertension. Br J Clin Pract. 1971 Mar;25(3):135-7.
      7: Wahbi AA, Bedair MM, Galal SM, Gazy AA. Spectrophotometric analysis of some guanidino drugs by acid-dye and charge-transfer complexation methods. J Pharm Biomed Anal. 1993 Aug;11(8):639-45.

      合成参考文献


      参考文献:10.1111/j.1432-1033.1986.tb09388.x
      摘要:Frelin C, Vigne P, Barbry P, Lazdunski M. Interaction of guanidinium and guanidinium derivatives with the Na+/H+ exchange system. Eur J Biochem. 1986 Jan 15;154(2):241–5. doi: 10.1111/j.1432-1033.1986.tb09388.x.
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