CAS: 455-40-3; 3,5-Difluorobenzoic Acid

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CAS号124-38-9 二氧化碳 | CAS号461-96-1 1-溴-3,5-二氟苯 | CAS号651027-07-5 3,5-difluoro-4-... | CAS号372-18-9 1,3-二氟苯 | CAS号651027-02-0 (2,6-difluoroph... | CAS号651027-03-1 (3-bromo-2,6-di... | CAS号651027-05-3 (3,4-dibromo-2,... | CAS号651027-04-2 (3,5-dibromo-2,... | CAS号121602-93-5 3,4,5-三氟苯甲酸 | CAS号914637-31-3 3-氟-5-甲氧基苯乙腈 | CAS号198077-69-9 N-(3,5-二氟-苯基)-甲酰胺 | CAS号129589-62-4 2-Methyl-2-prop... | CAS号350-19-6 3,5-二氟苯甲酸乙酯 | CAS号331765-71-0 3,5-二氟-2-硝基苯甲酸 | CAS号132980-99-5 3,5-二氟苯甲酰胺 | CAS号126674-78-0 2-氨基-3,5-二氟苯甲酸 | CAS号129714-97-2 3,5-二氟苯甲酰氯 | CAS号176548-72-4 3-氟-5-甲氧基苯甲酸 | CAS号244022-63-7 3,5-二氟苯甲酰肼

1,3-二氟苯置于氢氧化钾,正丁基锂,溴,仲丁基锂,二异丙胺体系中,用 四氢呋喃,乙醚,乙醇,正己烷,环己烷,水 作为反应溶剂,化学反应 5.25H,反应生成 3,5-二氟苯甲酸
参考文献:探索结构机遇:1,3-二氟苯的区域柔性取代
标题:探索结构机遇:1,3-二氟苯的区域柔性取代
摘要:为了证明现代有机金属方法的优越性,廉价的起始材料 1,3-二氟苯已被选择性地转化为三种苯甲酸和所有七种溴苯甲酸.同位上的两个氟原子.制备2,6-二氟苯甲酸.在由直接金属化和羧化组成的一锅反应中.3-溴-2,6-二氟苯甲酸路线的关键步骤是去质子化引发的溴从2-位迁移到4-位.所有其他产品均通过(2,6-二氟苯基)三乙基硅烷获得.与氟原子相邻的位点连续去质子化,然后进行适当的亲电取代,不仅提供 5-溴-2,4-二氟苯甲酸,还提供 3,5-二溴-2,6-二氟苯基三乙基硅烷及其 5-碘类似物.这些反过来产生 3,4-二溴-2,6-二氟苯基三乙基硅烷 (I) 和它的 4-碘类似物在最重的卤素的碱介导迁移后产生 2-溴-4,6-二氟苯甲酸和 2-溴-3,5-二氟苯甲酸可直接获得.中间体 I 的区域受控单脱溴提供了(4-溴-2,6-二氟)三乙基硅烷,这开辟了通过羧化和原脱甲硅烷化反应生成 3,5-二氟苯甲酸和
DOI:10.1002/ejoc.200300354

专利信息

专利号:US-2002192767-A1
优先权日:1999-10-13
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli . Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:WO-02068613-A1
优先权日:2001-02-28
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
权利人:UNIV LELAND STANFORD JUNIOR; KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli. Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:US-2002045220-A1
优先权日:1999-10-13
标题:Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. col. This achievement permits a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:WO-2024126692-A1
优先权日:2022-12-15
标题 :Peracid promoters in the iridium-catalyzed hydrosilylation synthesis of haloalkylorganosilanes
发明人：SCHOLZ HENRIK; KROKE EDWIN; KRAUSHAAR KONSTANTIN; GLATZER HOLGER JÃœRGEN; LEWIS KENRICK MARTIN; WAGNER ROLAND
权利人:MOMENTIVE PERFORMANCE MAT GMBH
摘要:The present invention is directed at a process for producing a compound of Formula (I): (R1)y(R2O)3-ySiCH2CHR3CR4R5X comprising reacting (a) an olefinic halide; (b) an alkoxysilane; (c) a catalytically effective amount of iridium-containing catalyst; and (d) a reaction-promoting effective amount of a peroxycarboxylic acid to produce the product of Formula (I).

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.