CAS: 4457-32-3; 4-Nitrobenzyl Carbonochloridate

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CAS号75-44-5 光气 | CAS号619-73-8 对硝基苯甲醇 | CAS号141890-67-7 (4-nitrophenyl)... | CAS号90505-36-5 (S)-3-疏基吡咯烷-1-基... | CAS号96034-57-0 反式-4-羟基-1-(4-硝基... | CAS号96036-02-1 保护美罗培南 | CAS号96034-64-9 美罗培南侧链 | CAS号68011-66-5 3-hydroxybenzo[... | CAS号104457-91-2 (4-nitrophenyl)... | CAS号102637-13-8 (4-nitrophenyl)... | CAS号619-73-8 对硝基苯甲醇 | CAS号140843-12-5 (1S,2R,5S)-5-Me...

对硝基苯甲醇,氯甲酸三氯甲酯置于4-二甲氨基吡啶体系中,用 甲苯 作为反应溶剂,化学反应 24.0H,反应生成 氯甲酸对硝基苄酯
参考文献:新型杂硒代氨基甲酸酯的体外自由基清除和细胞毒活性
标题:新型杂硒代氨基甲酸酯的体外自由基清除和细胞毒活性
摘要:合成了含有氨基甲酸酯部分的新型硒氰酸酯和二硒化物衍生物,并在体外进行了评估,以确定它们的细胞毒性和自由基清除特性.针对一组人类细胞系(包括ccrf-Cem(淋巴母细胞性白血病),Ht-29(结肠癌),Htb-54(肺癌),Pc-3(前列腺癌),Mcf-7(乳腺癌))测试了细胞毒活性),184B5(非恶性,源自乳腺)和beas-2B(非恶性,源自支气管上皮).大多数化合物对gi 50均显示出高抗增殖活性在mcf-7,Ccrf-Cem和pc-3细胞中,其值低于10μm.通过测试新型硒化合物清除dpph和abts自由基的能力,证实了它们的自由基清除性能.基于硒基谷胱甘肽过氧化物酶(gpxs)的活性,进一步筛选化合物1A,2E和2H在硫醇存在下还原过氧化氢的能力.结果表明化合物1A模拟gpxs活性.细胞毒性参数,自由基清除活性和adme谱指出1A是有前途的候选药物.
DOI:10.1016/j.Bmc.2015.02.048

专利信息

专利号:US-7429658-B2
优先权日:2003-09-11
标题 :Synthesis of protected pyrrolobenzodiazepines
发明人：HOWARD PHILIP; MASTERSON LUKE
权利人:SPIROGEN LTD
摘要:A method of synthesis of a N-10 protected PBD compound of formula (I): n nvia an intermediate of formula (II) or formula (V):

专利号:US-8557979-B2
优先权日:2004-06-10
标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
发明人：CHOI WOO-BAEG; KOWALIK EWA
权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

专利号:US-4786684-A
优先权日:1986-08-21
标题 :Benzylthioether-linked solid support-bound thiol compounds and method for peptide synthesis
发明人：GLASS JOHN D
权利人:SINAI SCHOOL MEDICINE
摘要:A method for the synthesis of sulfydryl-containing peptides which comprises forming a benzylthioether-linked solid support-bound thiol compound having at least one functional group for generating at least one peptide bond, sequentially coupling at least one protected amino acid or peptide to the compound until a peptide having desired amino acid sequence is obtained, and cleaving the benzylthioether linkage to release the peptide from the support with concomitant regenertion of the sulfydryl group in the peptides. The invention also encompasses compounds having the general formula wherein X is H, NH2, or acyl-NHY, said acyl being an amino acid or a peptide; Y is H, COOH, CONHNH2, the ester COOR1 in which R1 is selected from the group consisting of methyl, ethyl, phenyl, ortho-nitrophenyl and para-nitrophenyl, the amide CONH2, or the amide CONHR2 in which R2 is an amino acid or peptide; and providing that X and Y cannot both be H.

专利号:US-5817758-A
优先权日:1995-06-07
标 题:P-nitrobenzyl side-chain protection for solid-phase synthesis
发明人：LYTTLE MATTHEW H; HOCKER MICHAEL D
权利人:TERRAPIN TECH INC
摘要:Solid phase supported synthesis of peptides and other molecules using protecting groups comprising p-nitrobenzyl is described.

专利号:US-4309346-A
优先权日:1980-03-27
标 题:Process for the preparation of 1-carbapenems and intermediates via trithioorthoacetates
发明人：CHRISTENSEN BURTON G; RATCLIFFE RONALD W; SALZMANN THOMAS N
权利人:MERCK & CO INC
摘要:Disclosed is a process for the total synthesis of 1-carbapenem antibiotics (I) from L-aspartic acid via intermediates II and III: I II III wherein R is hydrogen, a pharmaceutically acceptable ester moiety or salt cation, or a readily removable blocking group; R6 and R7 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl; R1' is hydrogen or a protecting group; and Ra, Rb and Rc are independently selected from alkyl, aryl and aralkyl.

专利号:US-4378315-A
优先权日:1980-05-29
标题:Process for the preparation of thienamycin and intermediates
发明人：CHRISTENSEN BURTON G; RATCLIFFE RONALD W; SALZMANN THOMAS N
权利人:MERCK & CO INC
摘要:Disclosed is a process for the total synthesis of thienamycin from L-aspartic acid via intermediate III: ##STR1## R=H, blocking group or salt cation.