CAS: 3663-80-7; 2,3-Dihydrobenzo[b][1,4]Dioxine-2-Carboxylic Acid

该化合物是有机化合物,其特点是双环结构,包括一个被二氧烷环连接的苯环,该化合物在二氧烷环的2位置上有一个碳球酸功能组(COOH),这增加了其酸性.该化合物在室温下一般是白色的,在白色至白色的固体,在水和酒精等极溶剂中溶解.该化合物由于存在碳箱酸组而具有溶解性.该化合物对各个领域,包括制药和有机合成业感兴趣,因为其作为较复杂的分子的建筑块具有潜力.该化合物的再活性受到碳箱酸的电阻附性质的影响,该物质可以参与各种化学反应,例如化和恐吓.此外,该化合物可能展示生物活动,从而成为对医药化学进行进一步研究的候选对象.应当参考安全数据,以便处理和使用,如所有化学物质一样.

结构式图片

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

CAS号3663-79-4 1,4-苯并二噁烷-2-甲酸甲酯 | CAS号1008-92-0 2,3-二氢苯并[1,4]二恶... | CAS号4739-94-0 2,3-二氢-1,4-苯并二噁... | CAS号120-80-9 邻苯二酚 | CAS号623-73-4 重氮乙酸乙酯 | CAS号274-09-9 1,2-亚甲二氧基苯 | CAS号4739-94-0 2,3-二氢-1,4-苯并二噁... | CAS号3663-79-4 1,4-苯并二噁烷-2-甲酸甲酯 | CAS号3663-81-8 2,3-二氢-1,4-苯并二恶... | CAS号98572-00-0 (S)-2-羟甲基-1,4-苯并二恶烷 | CAS号70918-00-2 2-(1-哌嗪羰基)-1,4-... | CAS号74191-85-8 多沙唑嗪 | CAS号309923-57-7 4-[(2,3-二氢-1,4-... | CAS号848170-22-9 N-甲氧基-N-甲基-2,3-... | CAS号90557-92-9 2,3-二氢-1,4-苯并二噁... | CAS号92405-50-0 N-(2-aminoethyl...

合成工艺路线路线简述

    1,4-苯并二氧六环-2-甲酸乙酯置于sodium Hydroxide体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应生成1,4-苯并二烷-2-羧酸
    参考文献:Malipeddi,Himaja; Gowda,Visruth; Das,Moonjit,Indian Journal Of Heterocyclic Chemistry,2015,Vol. 25,# 2,P. 113-118
    标题:Malipeddi,Himaja; Gowda,Visruth; Das,Moonjit,Indian Journal Of Heterocyclic Chemistry,2015,Vol. 25,# 2,P. 113-118

    海关参考信息

    专利信息


    专利号:US-7344863-B2
    优先权日:1998-03-13
    标题:Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
    发明人:LI WU-BO; JESSEE JOEL A; SCHUSTER DAVID; XIA JIULIN; GEBEYEHU GULILAT
    权利人:INVITROGEN CORP
    摘要:The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compounds having a formula selected from the group consisting of formula I and formula II (or salts or derivatives thereof), preferably 4-methylmorpholine N-oxide or betaine (carboxymethyltrimethylammonium), and further comprising one or more compounds selected from the group consisting of proline and an N-alkylimidazole compound, and more preferably proline, 1-methylimidazole or 4-methylimidazole. The invention further relates to methods for enhanced, high-fidelity synthesis of nucleic acid molecules, including via amplification (particularly PCR), reverse transcription, and sequencing methods. The invention also relates to nucleic acid molecules synthesized by these methods, to fragments or derivatives thereof, and to vectors and host cells comprising such nucleic acid molecules, fragments, or derivatives. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the compositions of the invention.

    专利号:US-10865116-B2
    优先权日:2017-03-24
    标 题:Process for the synthesis of IZM-2 zeolite in the presence of a template, 1,6-bis(methylpiperidinium)hexane dihydroxide
    发明人:MARTINEZ FRANCO RAQUEL; BATS NICOLAS
    权利人:IFP ENERGIES NOW
    摘要:A novel process is described for the preparation of a microporous crystalline solid, known as IZM-2 microporous solid or IZM-2 zeolite. This novel process consists of carrying out the synthesis of IZM-2 zeolite by conversion/transformation of a zeolite with structure type FAU in a fluorinated medium under hydrothermal conditions. In particular, said novel process consists of carrying out the synthesis of an IZM-2 zeolite in a fluorinated medium starting from a zeolite with structure type FAU used as the source of silicon and aluminium and a specific organic molecule or template comprising two quaternary ammonium functions, namely 1,6-bis(methylpiperidinium)hexane dihydroxide.

    专利号:US-10875778-B2
    优先权日:2017-03-24
    标 题 :Process for the synthesis of IZM-2 zeolite in the presence of a template, 1,6-bis(methylpiperidinium)hexane dibromide
    发明人:MARTINEZ FRANCO RAQUEL; BATS NICOLAS
    权利人:IFP ENERGIES NOW
    摘要:A novel process is described for the preparation of a microporous crystalline solid, known as IZM-2 microporous solid or IZM-2 zeolite. This novel process consists of carrying out the synthesis of IZM-2 zeolite by conversion/transformation of a zeolite with structure type FAU under hydrothermal conditions. In particular, said novel process consists of carrying out the synthesis of an IZM-2 zeolite starting from a zeolite with structure type FAU used as the source of silicon and aluminium and a specific organic molecule or template comprising two quaternary ammonium functions, namely 1,6-bis(methylpiperidinium)hexane dibromide.

    专利号:US-5684191-A
    优先权日:1996-10-31
    标 题 :Process for the combined synthesis of betaine and choline chloride
    发明人:BELLIS HAROLD EDWARD; JEMISON THOMAS ROBERT; MATHRE OWEN B
    权利人:DUCOA LP
    摘要:A process for the combined synthesis of betaine and choline chloride from monochloroacetic acid, trimethylamine and ethylene oxide by first reacting trimethylamine with monochloroacetic acid, and then reacting ethylene oxide with the reaction product from the previous step.

    专利号:US-4997991-A
    优先权日:1990-03-26
    标 题 :Synthesis of diethynylbenzene
    发明人:CAROSINO LAWRENCE E; HERAK DAVID C
    权利人:HERCULES INC
    摘要:The invention provides an inexpensive synthesis process for preparation of diethynylbenzene monomers that are useful in the preparation of polyacetylenes. This process provides for the preparation of thermally sensitive monomers in a one-pot reaction using readily available materials at low temperatures in an environment capable of absorbing large amounts of energy. Divinylbenzene is first brominated and then dehydrobrominated with sodium hydroxide or potassium hydroxide preferably in the presence of a phase transfer agent followed by distillation to recover the diethylnylbenzene product.

    专利号:US-5529929-A
    优先权日:1995-06-07
    标 题 :Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens
    发明人:ROSSI JR RICHARD F; ZEPP CHARLES M; HEEFNER DONALD L
    权利人:SEPRACHEM INC
    摘要:A process for resolving racemic alkyl 1,4-benzodioxan-2-carboxylates useful as intermediates in the synthesis of optically pure pharmaceutical compounds such as (S)-doxazosin is disclosed. The process utilizes a microbial enzyme derived from Serratia marcescens to catalyze the enantioselective hydrolysis of the alkyl (S)-1,4-benzodioxan-2-carboxylate enantiomer of the racemic mixture to its corresponding carboxylic acid at a faster rate than the R-enantiomer. An enantiomerically pure S-configured carboxylic acid is thereby formed for subsequent pharmaceutical synthesis. The nonhydrolyzed alkyl (R)-1,4-benzodioxan-2-carboxylate enantiomer can also be isolated and racemized, and the enzymatic hydrolysis reaction repeated.
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    合成参考文献


    摘要:Desroches, J.; Paquin, J.-F., Science of Synthesis Knowledge Updates, (2016) 1, 384.
    摘要:Zhou, Q.-Q.; Wei, Y.; Lu, L.-Q.; Xiao, W.-J., Science of Synthesis: Photocatalysis in Organic Synthesis, (2018) 1, 195.
    摘要:Zhou, Q.-Q.; Wei, Y.; Lu, L.-Q.; Xiao, W.-J., Science of Synthesis: Photocatalysis in Organic Synthesis, (2018) 1, 178.
    摘要:Brasholz, M., Science of Synthesis: Photocatalysis in Organic Synthesis, (2018) 1, 375.
    摘要:Ouellet-Du Berger, M.-R.; Paquin, J.-F., Science of Synthesis: Knowledge Updates, (2023) 2, 285.
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