专利号:EP-1575929-B1 优先权日:2002-12-19 标 题 :The method for production of semi-finished products useful in synthesis of paclitaxel 发明人:KOLESINSKA BEATA; KAMINSKI J ZBIGNIEW; KAMINSKA E JANINA 权利人:AGROPHARM S A 摘要:The method for production of the semi-finished products useful in synthesis of Paclitaxel with the generalized formula (2), characterized in that phenyl isoserine derivatives, or mixtures of their epimerides with various configurations on the carbon 2' or their salts, are treated with triazine type condensing agent, possible in the presence of tertiary amine, in medium of anhydrous organic solvent, and the triazine esters produced are treated with Baccatin III, in medium of anhydrous organic solvent, possible in the presence of a catalyst.
专利号:US-9227965-B2 优先权日:2011-09-22 标题 :Processes and intermediates for preparing a macrocyclic protease inhibitor of HCV 发明人:HORVATH ANDRAS; DEPRÉ DOMINIQUE PAUL MICHEL; ORMEROD DOMINIC JOHN 权利人:JANSSEN PHARMACEUTICALS INC 摘要:Disclosed is a process for the preparation of a cinchonidine salt of formula (IV) via an aqueous solution of a racemic 4-hydroxy-1,2-cyclopentanedicarboxylic acid, which is subjected to cyclization without removing water, by the addition of a water-miscible organic solvent to the aqueous solution and, again without removing water, adding cinchonidine to the aqueous-organic solvent solution so as to obtain the cinchonidine salt of the lactone acid. The cinchonidine salt is allowd to crystallize so as to obtain the enantiomerically purified crystalline lactone acid cinchonidine salt (IV). The enantiomerically pure salt is an intermediate in the synthesis of HCV inhibitor compound of formula (I).
专利号:WO-2023287345-A1 优先权日:2021-07-16 标 题 :Aqueous solid phase peptide synthesis 发明人:PAWLAS JAN; LUDEMANN-HOMBOURGER OLIVIER 权利人:POLYPEPTIDE LABORATORIES HOLDING PPL AB 摘要:The present invention relates to a solid phase peptide synthesis (SPPS) where the coupling of amino acids is performed in an aqueous solution comprising at least one organic co-solvent miscible with water. The aqueous solution is capable of sufficiently solubilize the activated Fmoc-α-amine protected amino acid or activated Fmoc-α-amine protected peptide fragment, and where the resin is capable of swelling in the presence of the aqueous solution above about 4 mLg-1. The invention also encompasses a method for regeneration of spent aqueous solution from the SPPS.
专利号:US-2008194801-A1 优先权日:2007-02-14 标题:Robust multidentate ligands for diagnosis and anti-viral drugs for influenza and related viruses 发明人:SWANSON BASIL I; SCHMIDT JURGEN G; IYER SURI S; KALE RAMESH R 权利人:SWANSON BASIL I; SCHMIDT JURGEN G; IYER SURI S; KALE RAMESH R 摘要:Design and synthesis of a novel library of compounds comprising a spacer with an attachment element on one terminus and a recognition element on the other terminus is presented. The library of compounds can be attached to a solid support and used as an integral component of sensors and biosensors or the library of compounds can be used as antiviral drugs or to isolate pathogens from complex mixtures for further analysis.
专利号:PL-194032-B1 优先权日:2002-12-19 标 题 :A method of producing intermediates useful in the synthesis of paclitaxel
专利号:EP-1575929-A1 优先权日:2002-12-19 标 题 :The method for production of semi-finished products useful in synthesis of paclitaxel