CAS: 314771-88-5; (S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)Oxy)Quinazolin-4-Amine

上下游产品

4-((3-Chloro-4-Fluorophenyl)Amino)-6-Nitroquinazolin-7-Ol
阿法替尼 Afatinib 850140-72-6
N-(3-氯-4-氟苯基)-7-氟-6-硝基-4-喹唑啉胺 N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine 162012-67-1
7-氯-N-(3-氯-4-氟苯基)-6-硝基-4-氨基喹唑啉 7-Chloro-N-(3-Chloro-4-Fluorophenyl)-6-Nitroquinazolin-4-Amine 179552-73-9
(S)-6 Nitro-7-((Tetrahydrofuran-3-yl)Oxy)Quinazolin-4(3H)-One 1621182-18-0
阿法替尼中间体 N-((3-Chloro-4-Fluorophenyl)-6-Nitro-7-Phenylsulfonyl)Quinazolin-4-One 945553-94-6

7-氯-N-(3-氯-4-氟苯基)-6-硝基-4-氨基喹唑啉置于potassium Tert-Butylate,1-{[19-氨基-7-(2-氨基-2-羰基乙基)-10-(3-氨基-3-羰基丙基)-16-(4-乙基苯甲基)-13-(1-甲基丙基)-6,9,12,15,18-五羰基-1,2-二硫杂-5,8,11,14,17-五氮杂环二十碳烷-4-基]羰基}脯氨酰亮氨酰甘氨酸酰胺体系中,用 四氢呋喃,N,N-二甲基甲酰胺,叔丁醇 作为反应溶剂,化学反应 12.0H,反应生成 N-(3-氯-4-氟苯基)-6-硝基-7-[[(3S)-四氢-3-呋喃基]氧基]-4-喹唑啉胺
参考文献:一种阿法替尼中间体杂质及其制备方法,用途
标题:一种阿法替尼中间体杂质及其制备方法,用途
摘要:本发明公开了一种阿法替尼中间体杂质及其制备方法,用途,本发明的阿法替尼中间体杂质为氧化偶氮二聚物,所述氧化偶氮二聚物是在阿法替尼中间体制备过程中在有氧条件下存在发生聚合反应生成,为4‑[(3‑氯‑4‑氟苯基)氨基]‑6‑胺基‑7‑((S)‑四氢呋喃‑3‑基氧基)‑喹唑啉的氧化偶氮二聚物,其残留在阿法替尼中的可能性较大,最终影响阿法替尼的产品质量;本发明的方法可快速简单的制备所述氧化偶氮二聚物,为阿法替尼制备中形成的杂质提供对照品,不需要采用分解阿法替尼自身来得到杂质对照品,可有效降低阿法替尼的质量研究成本及难度.

专利信息

专利号:WO-2023098592-A1
优先权日:2021-11-30
标题:Preparation method for carbon-loaded iron-based catalyst and use thereof in synthesis of intermediates of anti-cancer inhibitors

专利号:CN-114315595-B
优先权日:2021-11-30
标题 :Preparation method of a carbon-supported iron-based catalyst and its application in the synthesis of anti-cancer inhibitor intermediates

专利号:US-8188274-B2
优先权日:2006-01-26
标题 :Process for preparing aminocrotonylamino-substituted quinazoline derivatives
发明人：SCHROEDER JUERGEN; DZIEWAS GEORG; FACHINGER THOMAS; JAEGER BURKHARD; REICHEL CARTSEN; RENNER SVENJA
权利人:SCHROEDER JUERGEN; DZIEWAS GEORG; FACHINGER THOMAS; JAEGER BURKHARD; REICHEL CARTSEN; RENNER SVENJA; BOEHRINGER INGELHEIM INT
摘要:The invention relates to an improved process for preparing aminocrotonylamino-substituted quinazoline derivatives of general formula (I) n nwherein the groups R a , R b , R c and R d have the meanings given in the claims, as well as sulphonyl derivatives of formulan n nand the use thereof as synthesis components for preparing quinazolines of formula (I). The quinazoline derivatives of formula (I) are inhibitors of signal transduction mediated by tyrosinekinases and by the Epidermal Growth Factor-Receptor (EGF-R) and are therefore particularly suitable for the treatment of tumoral diseases.

专利号:CN-114315595-A
优先权日:2021-11-30
标题:Preparation method of carbon-supported iron-based catalyst and synthesis application of anti-cancer inhibitor intermediate thereof