CAS: 236406-61-4; Tert-Butyl 2,7-Diazaspiro[4.5]Decane-7-Carboxylate

相似化合物

1279856-08-4 885268-42-8 1086395-71-2

2,7-Diazaspiro[4.5]Decane-1,3,6,8-Tetraone置于lithium Aluminium Tetrahydride,三氟乙酸体系中,用 四氢呋喃,乙醇,二氯甲烷 用作溶剂,化学反应 48.0H,反应生成2,7-二氮杂螺[4.5]癸烷-2-羧酸叔丁酯,2,7-二氮杂螺[4.5]癸烷-7-羧酸叔丁酯
参考文献:吡咯烷和哌啶基螺二胺支架的合成和差异官能化
标题:吡咯烷和哌啶基螺二胺支架的合成和差异官能化
摘要:描述了一系列螺二胺支架的合成和差异取代/保护.还描述了基于2,7-二氮杂螺[4.5]癸烷选择性获得两种单-N-甲基异构体的方法.与该化学反应有关的关键前体易于重排,并报道了解决该问题的方法.而直接单声道-氨基甲酰化作用(boc)无效,选择性地脱保护对称对称的二胺衍生的双重boc保护的衍生物可提供mono-Boc变体.还进行了n-芳基化,以引入2-氯-5-吡啶基部分的一系列单取代的螺二胺为例,该2-氯-5-吡啶基部分是优先的烟碱激动剂亚结构,以提供单芳基化的仲和叔螺二胺变体.
Doi:10.1016/j.Tet.2013.03.064

专利信息

专利号:US-10280189-B2
优先权日:2012-07-17
标题:Method for the synthesis of aminoalkylenephosphonic acid
发明人：BURCK SEBASTIAN; LECLERCQ CEDRIC NICOLAS; NOTTE PATRICK
权利人:MONSANTO TECHNOLOGY LLC
摘要:A method for the synthesis of an aminoalkylenephosphonic acid or its phosphonate esters including the following steps: a) forming, in the presence of an aldehyde or ketone and an acid catalyst, a reaction mixture by mixing a compound having at least one HNR 1 R 2 moiety or a salt thereof, with a compound having one or more P—O—P anhydride moieties, the moieties having one P atom at the oxidation state (+III) and one P atom at the oxidation state (+III) or (+V), wherein the ratio of moles of aldehyde or ketone to N—H moieties is 1 or more and wherein the ratio of N—H moieties to P—O—P anhydride moieties is 0.3 or more, and b) recovering the resulting aminoalkylenephosphonic acid having compound or its phosphonate esters.

专利号:US-9676799-B2
优先权日:2012-07-17
标 题 :Method for the synthesis of N-(phosphonomethyl)glycine
发明人：BURCK SEBASTIAN; BRUYNEEL FREDERIC; NOTTE PATRICK
权利人:STRAITMARK HOLDING AG
摘要:A method for the synthesis of N-(phosphonomethyl)glycine or one of its derivatives selected from the group consisting of its salts, its phosphonate esters, or its phosphonate ester salts, which includes the steps of: a) forming, in the presence an acid catalyst, a reaction mixture having 2,5-diketopiperazine, formaldehyde and a compound including one or more P-0-P anhydride moieties, the moieties having one P atom at the oxidation state (+III) and the other P atom at the oxidation state (+III) or (+V), to form N,N′-bisphosphonomethyl-2,5-diketopiperazine, its mono- to tetra phosphonate esters, the dehydrated forms of N,N′-bisphosphonomethyl-2,5-diketopiperazine and the phosphonate esters of its dehydrated forms; and b) hydrolyzing the N,N′-bisphosphonomethyl-2,5-diketopiperazine, its dehydrated forms or their phosphonate esters to obtain N-(phosphonomethyl)glycine or one of its derivatives selected from the group consisting of its salts, its phosphonate esters and its phosphonate ester salts.

专利号:US-10464958-B2
优先权日:2012-07-17
标题 :Method for the synthesis of alpha-aminoalkylenephosphonic acid
发明人：NOTTE PATRICK; COGELS SAMUEL; BURCK SEBASTIAN
权利人:MONSANTO TECHNOLOGY LLC
摘要:The present invention is related to a new method for the synthesis of alpha-aminoalkylenephosphonic acid or its phosphonate esters comprising the steps of forming a reaction mixture by mixing a P—O—P anhydride moiety comprising compound, having one P-atom at the oxidation state (+III) and the other P-atom at the oxidation state (+III) or (+V), an aminoalkanecarboxylic acid and an acid catalyst, wherein said reaction mixture comprises an equivalent ratio of alpha-aminoalkylene carboxylic acid to P—O—P anhydride moieties of at least 0.2, and recovering the resulting alpha-aminoalkylene phosphonic acid compound or an ester thereof from the reaction mixture.

专利号:US-9150599-B2
优先权日:2012-07-17
标 题 :Method for the synthesis of N-(phosphonomethyl)glycine
发明人：BURCK SEBASTIAN; NOTTE PATRICK
权利人:STRAITMARK HOLDING AG
摘要:A method for the synthesis of N-(phosphonomethyl) glycine or one of its derivatives selected from the group of its salts, its phosphonate esters and its phosphonate ester salts, including the steps of: a) forming a reaction mixture having an acid catalyst, N,N′-bis(carboxymethyl)-2,5-diketopiperazine and a compound having one or more P—O—P anhydride moieties, wherein the moieties have one P atom at the oxidation state (+III) and the other P atom at the oxidation state (+III) or (+V), to form N,N′-bis(phosphonomethyl)-2,5-diketopiperazine, its dehydrated forms or their phosphonate esters; b) hydrolyzing the reaction mixture to form N-(phosphonomethyl)glycine or one of its derivatives selected from the group consisting of its salts, its phosphonate esters and its phosphonate ester salts.

专利号:US-2014342177-A1
优先权日:2011-12-07
标 题 :Synthesis of cupronickel nanowires and their application in transparent conducting films
发明人：WILEY BENJAMIN
权利人:UNIV DUKE
摘要:A method of synthesis to produce a conductive film including cupronickel nanowires. Cupronickel nanowires can be synthesized from solution, homogeneously dispersed and printed to make conductive films (preferably < 1,000 Ω/sq) that preferably transmit greater than 60% of visible light.

专利号:US-10183962-B2
优先权日:2014-02-25
标 题:Synthetic oligomers of Neisseria meningitis serogroup X and process of preparing them
发明人：GILL DAVINDER; HARALE KISHORE; CHHIKARA MANOJ KUMAR
权利人:MSD WELLCOME TRUST HILLEMAN LABORATORIES PVT LTD
摘要:The present invention relates to synthesis of novel higher oligomers and process of preparing the same. In particular the present invention relates to the chemical synthesis of oligomers of Neisseria meningitidis serogroup X (‘hereinafter Men-X), more particularly tetramer. The present invention provides Men-X capsular oligomers obtained from synthetic pathway using purified saccharides of specific chain length and provides said novel oligomers as candidates for the development of conjugate vaccine against bacterial meningitis caused due to Men-X infections.