CAS: 215935-23-2; The Metabolite Of Ivabradine

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    上下游产品

    1-[(7S)-3,4-dimethoxybicyclo-[4.2.0]°Cta-1,3,5-trien-7-yl]methanamine hydr°Chloride

    合成工艺路线路线简述

      📜N-{[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-Trien-7-Yl]Methyl}-3-(7,8-Dimethoxy-2-Oxo-1,2,4,5-Tetrahydro-3H-3-Benzazepin-3-yl)Propanimidamide 以30的收率获得盐酸伊伐布雷定的杂质去甲伊伐布雷定
      参考文献:Process For The Synthesis Of Ivabradine And Addition Salts Thereof With A Pharmaceutically Acceptable Acid
      标题:Process For The Synthesis Of Ivabradine And Addition Salts Thereof With A Pharmaceutically Acceptable Acid
      摘要:公式(i)的伊伐布雷定合成及其与药学上可接受的酸的加成盐的制备过程.

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      专利信息


      专利号:US-8101747-B2
      优先权日:2009-03-31
      标 题:Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
      发明人：PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERKIZ BERNARD
      权利人:PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERKIZ BERNARD; SERVIER LAB
      摘要:Process for the synthesis of ivabradine of formula (I): n nand addition salts thereof with a pharmaceutically acceptable acid.

      专利号:US-2010249397-A1
      优先权日:2009-03-31
      标 题:Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

      专利号:AU-2010201058-B2
      优先权日:2009-03-31
      标 题:New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

      专利号:EP-2241554-B1
      优先权日:2009-03-31
      标题 :Process for the synthesis of ivabradine and its pharmaceutically acceptable acid addition salts

      专利号:WO-2010112704-A1
      优先权日:2009-03-31
      标 题:Novel method for the synthesis of ivabradine and the addition salts thereof with a pharmaceutically acceptable acid

      专利号:JP-2010241809-A
      优先权日:2009-03-31
      标题 :A new method for the synthesis of ivabradine and its addition salts with pharmaceutically acceptable acids

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      主要参考文献

      参考标题: Novel Method For The Synthesis Of Ivabradine And The Addition Salts Thereof With A Pharmaceutically Acceptable Acid Nouveau Procede De Synthese De L'Ivabradine Et De Ses Sels D'Addition A Un Acide Pharmaceutiquement Acceptable
      摘要:Procédé De Synthèse De L'Ivabradine De Formule (I) Et De Ses Sels D'Addition à Un Acide Pharmaceutiquement Acceptable.

      合成参考文献


      参考文献:10.1124/mol.119.115964
      摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964.
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