CAS: 20577-61-1; Methyl 2,4-Dioxopentanoate

相似化合物

13192-04-6 615-79-2 6376-59-6

上下游产品

sodium methylate oxalic acid diethyl ester acetone Dimethyl oxalateH-pyrazole-3-carboxylic acid methyl ester5-methyl-2-(4-nitro-phenyl)-2H-pyrazole-3-carboxylic acid methyl ester 5-methylisoxazole 3-carboxylic acid 3-methyl-5-isoxazolecarboxylic acid methyl 2-methylazulene-3-carboxylate

草酸二甲酯,丙酮置于sodium Methylate体系中,用 甲醇 用作溶剂,化学反应 3.0H,以68%的收率获得乙酰丙酮酸甲酯
参考文献:新型水溶性铂配合物(1R,2R-环己二胺-N,N')[2-羟基-4-氧代-2-戊烯基(2-)-O2]铂(II)的合成,结构和抗肿瘤活性.
标题:新型水溶性铂配合物(1R,2R-环己二胺-N,N')[2-羟基-4-氧代-2-戊烯基(2-)-O2]铂(II)的合成,结构和抗肿瘤活性.
摘要:二氢(1R,2R-环己二胺)铂(II)与2,4-二氧戊酸反应生成水溶性络合物,(1R,2R-环己二胺-N,N')[2-羟基-4-氧-2-戊烯基(2-)-O2]铂(II).配合物的结构通过x射线晶体分析确定.数据表明2,4-二氧代戊酸的乙酰丙酮基部分与铂(II)的螯合.该复合物在小鼠中显示出对小鼠白血病l1210的中等抗肿瘤活性(在200 Mg / Kg的剂量下t / C = 195%)和对顺铂耐药l1210白血病的高活性(在25 Mg剂量下t / C = 275%) /公斤).
Doi:10.1248/cpb.41.357

专利信息

专利号:US-12150934-B2
优先权日:2016-11-30
标 题 :Methods of using substituted pyrazole and pyrazole compounds and for treatment of hyperproliferative diseases
发明人：SIDDIQUI ARSHAD M; CIBLAT STEPHANE; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; GUO XIANGYU; SRIVASTAVA SANJAY; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW W; LUTHER MICHAEL; LEVINE JEDD
权利人:BANTAM PHARMACEUTICAL LLC
摘要:Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1, Z2, the ring system denoted by “aâ€?, R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.

专利号:US-11325903-B2
优先权日:2016-11-30
标 题:Substituted pyrazole compounds and methods of using them for treatment of hyperproliferative diseases
发明人：SIDDIQUI M ARSHAD; CIBLAT STEPHANE; DERY MARTIN; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; BRUNEAU-LATOUR NICOLAS; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW J; LUTHER MICHAEL; LEVINE JEDD
权利人:BANTAM PHARMACEUTICAL LLC
摘要:Disclosed are compounds useful, for example, in methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formulae (Ia), (Ib), (Ic), (Id) and (Ie), in which R 1 , L 1 , L 2 , Q, L 3 , R 3 , L 4 , R 4 , L 5 , and R 5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.