CAS: 20445-33-4; (S)-3,3,3-Trifluoro-2-Methoxy-2-Phenylpropanoyl Chloride

上下游产品

CAS号17257-71-5 (S)-(-)-α-甲氧基-α... | CAS号20445-31-2 (R)-(+)-α-甲氧基-α... | CAS号1461-22-9 三丁基氯化锡 | CAS号31590-84-8 2-(2,2-dimethyl... | CAS号108-93-0 环己醇

📜(R)-(+)-α-甲氧基-α-(三氟甲基)苯乙酸置于草酰氯体系中,用 正己烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 1.0H,反应生成甲氧基-三氟甲基苯
参考文献:N-杂环卡宾介导的苯酚对不对称烷基芳基烯酮的对映选择性加成
标题:N-杂环卡宾介导的苯酚对不对称烷基芳基烯酮的对映选择性加成
摘要:手性n-杂环卡宾(nhc)介导将2-苯基苯酚对映选择性加成到不对称的烷基芳基烯酮中,从而提供具有非常好对映体控制水平的ee-烷基-α-芳酸衍生物(最高ee达84%).在nhc促进的酯化反应中使用2-苯基苯酚和二氢苯酚,使用衍生自焦谷氨酸的三唑鎓预催化剂观测到对映体立体化学结果,这与这些过程中起作用的独特机理相符.
Doi:10.1002/adsc.200900538

专利信息

专利号:US-5468876-A
优先权日:1986-05-22
标题:Intermediates for the stereoconservative synthesis of 1-substituted (S)-and (R)-2-aminomethylpyrrolidines
发明人：FEDERSEL HANS-JUEGEN; HOE THOMAS; RAEMSBY STEN I; STROEM PETER H E
权利人:ASTRA AB
摘要:Disclosed are (R)- and (S)-isomers of the compounds of the Formulas II and III with at least 95% optical purity ##STR1## wherein R 1 and R 2 are the same or different and represent a hydrogen atom, a lower alkyl, lower alkenyl or lower alkynyl group, a cycloalkyl group or a group (CH 2 ) m Ph, wherein m is 0-3 and Ph is a substituted or unsubstituted phenyl group. n These compounds are intermediates in the stereoconservative synthesis of 1-substituted (S)- and (R)-2-aminomethylpyrrolidines.

专利号:US-5488131-A
优先权日:1994-03-23
标题:Synthesis of compounds with predetermined chirality
发明人：MYERS ANDREW G
权利人:CALIFORNIA INST OF TECHN
摘要:A method for synthesizing enantiomerically enriched chemical intermediates with predetermined chirality is described. The method comprises formation of a pseudoephedrine amide, followed by stereoselective alkylation at the alpha carbon. The chiral auxiliary can then be cleaved off, affording chiral end products useful for further transformations. The enantiomeric enrichment of the chiral end products may exceed 98%, and the chiral auxiliary can be recovered. Novel amides of pseudoephedrine used in this method are also disclosed.

专利号:US-7923226-B2
优先权日:2003-10-01
标题 :Synthesis of 1,2,4-butanetriol enantiomers from carbohydrates
发明人：FROST JOHN W
权利人:UNIV MICHIGAN STATE
摘要:A bioengineered synthesis scheme for the production of L-1,2,4-butanetriol, D-1,2,4-butanetriol and racemic mixtures thereof from a carbon source is provided. Methods of producing L-1,2,4-butanetriol, D-1,2,4-butanetriol and racemic mixtures thereof are also provided. Methods are also provided for converting D-1,2,4-butanetriol and L-1,2,4,-butanetriol to D,L-1,2,4-butanetriol trinitrate.

专利号:US-2011165641-A1
优先权日:2006-03-31
标 题 :Synthesis of 1,2,4-Butanetriol Enantiomers from Carbohydrates
发明人：FROST JOHN W
权利人:UNIV MICHIGAN STATE
摘要:A bioengineered synthesis scheme for the production of L-1,2,4-butanetriol, D-1,2,4-butanetriol and racemic mixtures thereof from a carbon source is provided. Methods of producing L-1,2,4-butanetriol, D-1,2,4-butanetriol and racemic mixtures thereof are also provided. Methods are also provided for converting D-1,2,4-butanetriol and L-1,2,4,-butanetriol to D,L-1,2,4-butanetriol trinitrate.

专利号:WO-2014011120-A1
优先权日:2012-07-13
标 题 :Endoperoxides, synthesis and uses thereof for the treatment of neoplastic diseases such as cancer
发明人：TAN NGUAN SOON; CHIBA SHUNSUKE
权利人:UNIV NANYANG TECH
摘要:The present invention generally relates to processes and methods for the synthesis of endoperoxide compounds. More specifically, the invention relates to a method for preparing endoperoxide compounds starting from an aryl imine of formula (I) in the presence of a metallic catalyst and oxygen. The present invention also relates to endoperoxide compounds of formula (III) and their pharmaceutically acceptable salts thereof, useful for therapy. All substituents are defined herein. Also disclosed are methods of treating cancer using the compounds of formula (III).

专利号:US-6033882-A
优先权日:1994-07-07
标题:Chiral synthesis of 2-hydroxy carboxylic acids with a dehydrogenase
发明人：HOLBROOK JOSEPH JOHN; WILLIS CHRISTINE LOUISE; JOHNSEN KEYJI; HATELEY MARTIN JOHN
权利人:GENZYME CORP
摘要:PCT No. PCT/EP95/02692 Sec. 371 Date May 29, 1997 Sec. 102(e) Date May 29, 1997 PCT Filed Jul. 7, 1995 PCT Pub. No. WO96/01892 PCT Pub. Date Jan. 25, 1996Inter alia, an enzyme, a 2-hydroxy carboxylic acid dehydrogenase, characterised in that it is obtainable from Lactobacillus delbrueckii ssp. Bulgaricus and in that it catalyses the production of (R)-hydroxy derivatives of 2-keto acids, which are unsubstituted in the 3-position, but which may be substituted in the 4-position or beyond is disclosed.