CAS: 18997-57-4; 4-Methyl-7-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-2H-Chromen-2-One

该化合物是一种含氟基基质,广泛用于酶学实验,特别是用于检测β-glucosidase活动,经β-glucosidase水解后,释放出高荧光4-甲基苯丙酮(4-MU),能够进行敏感和定量测量,该化合物因其高度特殊性,稳定性和低底底线荧光度而具有价值,适合生物化学,分子生物学和诊断研究的应用,其水溶性和可靠的动能特性进一步提高了其在端点和连续实验中的效用. 4-MUG通常用于酶动能学,淋病存储障碍和微生物酶特征分析研究.

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合成工艺路线路线简述

    📜羟甲香豆素置于甲醇,Sodium Hydroxide,Sodium Methylate,丙酮体系中,化学反应生成4-甲基伞形酮酰-β-D-吡喃葡糖酸苷
    参考文献:Constantzas; Kocourek,Collection Of Czechoslovak Chemical Communications,1959,Vol. 24,P. 1099,1102
    标题:Constantzas; Kocourek,Collection Of Czechoslovak Chemical Communications,1959,Vol. 24,P. 1099,1102

    海关参考信息

    专利信息


    专利号:US-5973228-A
    优先权日:1997-07-24
    标 题:Coniferin beta-glucosidase cDNA for modifying lignin content in plants
    发明人:CARLSON JOHN E; DHARMAWARDHANA D PALITHA; DOUGLAS CARL J; ELLIS BRIAN E
    权利人:UNIV BRITISH COLUMBIA
    摘要:A cDNA molecule encoding coniferin beta-glucosidase is disclosed. This enzyme catalyzes one of the last steps in the synthesis of lignin in plants. Plants having modified lignin content may be produced by transformation with this cDNA (or parts of the cDNA), for example, in either sense or antisense orientation. The invention includes methods of altering-lignin content in plants using this cDNA, as well as transformed plants, such as conifers, having modified lignin content.

    专利号:US-6287798-B1
    优先权日:1996-05-01
    标题 :Esculetin derivatives
    发明人:JAMES ARTHUR; ARMSTRONG LYLE
    权利人:IDG UK LTD
    摘要:The invention concerns novel 6- or 7-substituted derivatives of esculetin (6,7-dihydroxy-2H-1-benzopyran-2-one), their synthesis, and their application as substrates for the detection of micro-organisms in samples where a derivative is enzymatically cleaved to release a colored or fluorogenic marker which has a low tendency to diffuse through agar or other aqueous environments.

    专利号:ES-2289853-B1
    优先权日:2005-02-18
    标题:HEXASUBSTITUTE CYCLHEXAN ACTIVATOR OF THE BETA-GLUCOSIDASE ENZYME, SYNTHESIS PROCEDURE, PHARMACEUTICAL COMPOSITION CONTAINING IT AND ITS APPLICATIONS.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1002/mus.20473
    摘要:Slonim AE, Bulone L, Minikes J, Hays AP, Shanske S, Tsujino S, DiMauro S. Benign course of glycogen storage disease type IIb in two brothers: nature or nurture Muscle Nerve. 2006 Apr;33(4):571–4. doi: 10.1002/mus.20473.
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