CAS: 17832-16-5; Tris(Prop-2-Enyl) Benzene-1,3,5-Tricarboxylate

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CAS号554-95-0 均苯三甲酸 | CAS号107-18-6 烯丙醇 | CAS号2672-58-4 三甲基1,3,5-苯三羟酸酯

📜均苯三甲酸置于氯化亚砜,N,N-二甲基甲酰胺体系中,化学反应生成苯均三酸三烯丙基酯
参考文献:Screening Bicyclic Peptide Libraries For Protein-protein Interaction Inhibitors: Discovery Of A Tumor Necrosis Factor-α Antagonist
标题:Screening Bicyclic Peptide Libraries For Protein-protein Interaction Inhibitors: Discovery Of A Tumor Necrosis Factor-α Antagonist
摘要:Protein-Protein Interactions Represent A New Class Of Exciting But Challenging Drug Targets,Because Their Large,Flat Binding Sites Lack Well-Defined Pockets For Small Molecules To Bind. We Report Here A Methodology For Chemical Synthesis And Screening Of Large Combinatorial Libraries Of Bicyclic Peptides Displayed On Rigid Small-Molecule Scaffolds. With Planar Trimesic Acid As The Scaffold,The Resulting Bicyclic Peptides Are Effective For Binding To Protein Surfaces Such As The Interfaces Of Protein-Protein Interactions. Screening Of A Bicyclic Peptide Library Against Tumor Necrosis Factor-Alpha (Tnf Alpha) Identified A Potent Antagonist That Inhibits The Tnf Alpha-Tnf Alpha Receptor Interaction And Protects Cells From Tnf Alpha-Induced Cell Death. Bicyclic Peptides Of This Type May Provide A General Solution For Inhibition Of Protein-Protein Interactions.
Doi:10.1021/ja405106U

专利信息

专利号:US-7728088-B2
优先权日:2002-08-06
标题 :Synthesis of statistical microgels by means of controlled radical polymerisation
发明人：DESTARAC MATHIAS; BAVOUZET BRUNO; TATON DANIEL
权利人:RHODIA OPERATIONS
摘要:The invention relates to a method of preparing statistical microgels. The inventive method comprises a step involving the radical polymerisation of a composition containing: at least one monoethylenically-unsaturated monomer, at least one multiethylenically-unsaturated monomer, a free radical source and a control agent. The invention also relates to first generation microgels thus prepared and all the compounds resulting from said microgels (next-generation microgels).

专利号:US-9868767-B2
优先权日:2013-05-23
标 题:Chemical synthesis and screening of bicyclic peptide libraries
发明人：PEI DEHUA; UPADHYAYA PUNIT; LIAN WENLONG; TRINH THI
权利人:OHIO STATE INNOVATION FOUNDATION
摘要:Disclosed herein are bicyclic peptide compounds, compositions comprising same, methods for making same, and libraries comprising same. The disclosed compounds, in various aspects, are useful for treating a variety of disorders, including inflammatory disorders, autoimmune disorders, and disorders of uncontrolled cellular proliferation. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-2006106178-A1
优先权日:2002-08-06
标题:Synthesis of statistical microgels by means of controlled radical polymerisation

专利号:AU-2005248117-B2
优先权日:2004-05-14
标题 :Synthesis of copolymers in the form of a mikto star by controlled radical polymerization

专利号:AU-2005248117-A1
优先权日:2004-05-14
标 题:Synthesis of copolymers in the form of a mikto star by controlled radical polymerization

专利号:US-2008114128-A1
优先权日:2004-05-14
标 题 :Synthesis of Copolymers in the Form of a Mikto Star by Controlled Radical Polymerization