CAS: 1508-45-8; Mitopodozide
该化合物是一种化学化合物,在医学化学领域,特别是治疗癌症的潜在应用方面引起了人们的兴趣,其特点是它能够与细胞机制互动,有可能影响线粒体机能和血吸虫病途径;该化合物经常因其药理特性,包括其细胞对各种癌症细胞线的细胞毒性影响而进行研究;Mitopodozide可能表现出有助于其生物活动的具体结构特征,如功能组,这些功能组有助于针对肿瘤发展所涉及的蛋白质或酶.此外,其溶性,稳定性和生物利用率是影响其治疗功效的关键因素.研究继续探索行动机制,最佳剂量疗法和与Mitopodozide相关的潜在副作用,目的是提高它在临床环境中的效用.与许多此类化合物一样,正在进行的研究对于充分阐明其特性和治疗潜力至关重要.
- 英文名称Mitopodozide
- 中文名称米托肼
- IUPAC名称Naphtho(2,3-d)-1,3-dioxole-6-carboxylic acid, 5,6,7,8-tetrahydro-8-hydroxy-7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-, 2-ethylhydrazide, (5R-(5alpha,6alpha,7beta,8alpha))- (9CI)
- CAS编号1508-45-8
- MFCD编号:MFCD01699021
- EINECS号:216-138-1
- FDA UNII编号:6QYI7Y8OBO
- 分子式:C24H30N2O8分子量:474.507
- 产品CID: 733452
- 产品分类原料药 → 抗肿瘤药 → 天然来源类抗肿瘤药
物理性质
- 熔点100-120 °C
- 沸点619.6±55.0 °C(预测)
- 闪点328.5 °C
- 密度1.301±0.06 g/cm3(预测)
- PH:D -154° (c = 0.5 in chloroform)
- pKa:12.79±0.70(预测)
- PSA:127.74
- LogP:2.2672
- 折射率1.587
- 蒸汽压3.26E-16 mmHg at 25 °C
- 外观形态固体-粉末
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用该化合物是一种乙基羟丁酸衍生物,是卵巢癌中的线性毒物.
MSDS等安全信息
上下游产品
ethylhydrazine podofilox合成工艺路线路线简述
📜乙基肼,鬼臼毒素置于溶剂黄146体系中,用 甲醇 用作溶剂,化学反应 6.0H,以92%的收率获得米托肼
参考文献:鬼臼毒素的d环修饰酸性酰肼衍生物的合成及其作为微管蛋白抑制剂的抗癌研究.
标题:鬼臼毒素的d环修饰酸性酰肼衍生物的合成及其作为微管蛋白抑制剂的抗癌研究.
摘要:鬼臼毒素的d环修饰酸酰肼的新系列(化合物3A除外)是通过用各种肼裂解d环而得到的.此外,对合成的化合物针对人肿瘤细胞系mcf-7,Hela和a-549的抗癌活性进行了筛选,并且在合成的化合物3C和3F中显示出显着的抗癌活性,几乎与标准药物依托泊苷相似.还对活性化合物进行了分子建模研究,发现所获得的自由能与观测到的ic50值高度吻合.
Doi:10.1016/j.Bioorg.2019.103384
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2905399001-1,3-丙二醇
2906210000-苄醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2017218006-A1
优先权日:2014-07-31
标题 :Synthesis of Phosphoramidates
发明人：WILHELM THORSTEN; SPITZENSTÄTTER HANS-PETER; SCHÖNE OLGA; RICHTER FRANK; SCHREINER ERWIN
权利人:SANDOZ AG
摘要:A process for the preparation of a compound of formula (I) including all isomers, stereoisomers, enantiomers and diastereomers thereof (I), and salts thereof; the process comprising providing a mixture comprising a compound of formula (II) and a compound of formula (III) subjecting the mixture provided in a) to reaction conditions in the presence of one or more Lewis acids to the mixture provided in a), obtaining a mixture comprising the compound of formula (I).
专利号:US-2007021349-A1
优先权日:2005-04-28
标题:Orthogonally protected bifunctional amino acid
发明人：SRINIVASAN ANANTH; LUYT LEONARD G
权利人:SRINIVASAN ANANTH; LUYT LEONARD G
摘要:The present invention concerns novel orthogonally protected amino acids, there production and use for the synthesis of binding compounds usable in the diagnosis and treatment of proliferative diseases, in particular tumor diseases.
专利号:EP-3174892-A1
优先权日:2014-07-31
标 题:Synthesis of phosphoramidates
专利号:CA-2954940-A1
优先权日:2014-07-31
标 题 :Synthesis of phosphoramidates
专利号:US-8470965-B2
优先权日:2006-03-01
标题 :Methods and compositions related to cyclic peptide synthesis
发明人：SCHMIDT ERIC W; HATHAWAY BRIAN; NELSON JAMES T; DONIA MOHAMED S
权利人:SCHMIDT ERIC W; HATHAWAY BRIAN; NELSON JAMES T; DONIA MOHAMED S; UNIV UTAH RES FOUND
摘要:Disclosed are compositions and methods for prenylation of polymers such as peptides.
专利号:AU-2011235044-A1
优先权日:2010-03-31
标 题:Stereoselective synthesis of phosphorus containing actives
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Shi J, Wang X, Qiu J, Si Q, Sun R, Guo H, Wu Q. Roles of NF-kappaB and SP-1 in oxidative stress-mediated induction of platelet-derived growth factor-B by TNFalpha in human endothelial cells. J Cardiovasc Pharmacol. 2004 Jul;44(1):26-34.
3: Kuwahara J, Watanabe Y, Kayasuga T, Itoh K. Zn finger and nuclear localization of transcription factor Sp1. Nucleic Acids Symp Ser. 2000;(44):265-6. Epub 2003 May 5. Epub 2003 Feb 4. Czech. Epub 2001 Jul 3.
17: Veal GJ, Griffin MJ, Price E, Parry A, Dick GS, Little MA, Yule SM, Morland B, Estlin EJ, Hale JP, Pearson AD, Welbank H, Boddy AV. A phase I study in paediatric patients to evaluate the safety and pharmacokinetics of SPI-77, a liposome encapsulated formulation of cisplatin. Br J Cancer. 2001 Apr 20;84(8):1029-35.
合成参考文献
摘要:Arzneimittel-Forschung. Drug Research., 20(1467), 1970 []
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
参考文献:10.4049/jimmunol.157.8.3499
摘要:Youn BS, Kim KK, Kwon BS. A critical role of Sp1- and Ets-related transcription factors in maintaining CTL-specific expression of the mouse perforin gene. 1996 Oct 15;157(8):3499–509. doi: 10.4049/jimmunol.157.8.3499.
参考文献:10.1128/mcb.24.12.5496-5509.2004
摘要:Ma Z, Shah RC, Chang MJ, Benveniste EN. Coordination of Cell Signaling, Chromatin Remodeling, Histone Modifications, and Regulator Recruitment in Human Matrix Metalloproteinase 9 Gene Transcription. Mol Cell Biol. 2004 Jun;24(12):5496–509. doi: 10.1128/mcb.24.12.5496-5509.2004.
📝 需求与反馈
尽可能描述清楚需求与问题信息
