CAS: 127828-22-2; Tert-Butyl (2-(2-Aminoethoxy)Ethyl)Carbamate

该化合物是有机化合物,其特点是氨基乙基乙酸功能组;该物质具有与2-氨基甲基乙基基组相连的碳酸混合物,有助于其潜在的生物活动;1,1-二甲基乙酯的存在表明,该产品有一个分支的烷基结构,可影响其溶性和再活性;一般而言,氨基甲酸酯因其在农业中的杀虫剂和除草剂用途以及制药业中的应用而闻名,因为它们能够抑制某些酶;该化合物的具体结构表明,它可能具有独特的特性,例如生物系统中的稳定性或选择性增强;此外,由于存在氨基和醚的功能,它可能会产生水利性,影响其与生物膜的相互作用;总体而言,该化合物的特性使得其在各个领域,包括医药化学和农业化学领域引起兴趣.

结构式图片

相似化合物

165391-09-3 60792-79-2 2752-17-2

欧盟法规

C&L通报

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号60792-79-2 2,2'-氧代双(乙胺)二盐酸盐 | CAS号2752-17-2 2,2'-氧双(乙胺) | CAS号1046804-80-1 Tert-butyl 2-(2... | CAS号139115-91-6 2-(2-B°C-氨基乙氧基)乙醇 | CAS号302331-20-0 B°C-N-PEG2-Ms

合成工艺路线路线简述

    [2-{2-(T-Butoxycarbonylamino)Ethoxy}Ethyl]Methane Sulfonate置于sodium Azide,三苯基膦体系中,用 四氢呋喃,水,N,N-二甲基甲酰胺 用作溶剂,化学反应生成[2-(2-氨基乙氧基)乙基]氨基甲酸叔丁酯
    参考文献:Peptide Nucleic Acid Derivatives With Good Cell Penetration And Strong Affinity For Nucleic Acid
    标题:Peptide Nucleic Acid Derivatives With Good Cell Penetration And Strong Affinity For Nucleic Acid
    摘要:本发明提供了一类新型的肽核酸衍生物,它们具有非常好的细胞穿透性和对核酸的强结合亲和力.

    海关参考信息

    专利信息


    专利号:US-7230101-B1
    优先权日:2002-08-28
    标 题:Synthesis of methotrexate-containing heterodimeric molecules
    发明人:MURTHI KRISHNA K; SMITH CHASE C
    权利人:GPC BIOTECH INC
    摘要:The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:

    专利号:US-8420850-B2
    优先权日:2010-05-14
    标 题:Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers
    发明人:DUOCASTELLA CODINA LLUIS; MOLINA MARIA; ARAD OFIR; BORRELL BILBAO JOSE IGNACIO; GARCIA DAVID SANCHEZ; PETTERSON SALOM SOFIA HENRIETTE
    权利人:DUOCASTELLA CODINA LLUIS; MOLINA MARIA; ARAD OFIR; BORRELL BILBAO JOSE IGNACIO; GARCIA DAVID SANCHEZ; PETTERSON SALOM SOFIA HENRIETTE; IBERHOSPITEX SA
    摘要:The invention comprises compounds which are derived from a drug or a substance with therapeutic properties, and useful as reagents for the synthesis of biostable polymers including said drug in their backbone, namely polyurethanes, polyureas or polyurea urethanes that are biocompatible and biostable. The invention also comprises the processes for preparing the compounds and the polymers, and to the use of these polymers for the manufacture of medical devices.

    专利号:US-6486350-B1
    优先权日:1998-09-30
    标 题:Biological reagents and methods for determining the mechanism in the generation of β-amyloid peptide
    发明人:AUDIA JAMES E; HYSLOP PAUL A; NISSEN JEFFREY S; THOMPSON RICHARD C; TUNG JAY S; TANNER LAURA I
    权利人:ELAN PHARM INC; LILLY CO ELI
    摘要:Disclosed are biological reagents which comprise compounds that inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in determining the cellular mechanism involved in the generation of beta-amyloid peptide.

    专利号:US-12054471-B2
    优先权日:2018-07-13
    标题:Thiocycloheptyne derivatives and their use
    发明人:WETERINGS JOSEPHUS JOHANNES; RIJCKEN CRISTIANNE JOHANNA FERDINAND
    权利人:CRISTAL DELIVERY B V
    摘要:The present invention pertains to novel thiocycloheptyne derivatives of general formula (I): and in particular to thiacycloalkynesulfoimine derivatives and their synthesis. The invention also relates to the use of the novel thiocycloheptyne derivatives in coupling reactions with linkers and drugs. The invention further relates to the use of the novel thiocycloheptynes in bioorthogonal (copper-free) click reactions. The invention further pertains to the use of the novel thiocycloheptyne derivatives in the generation of advanced multifunctional drug delivery systems (drug-loaded) nanoparticles.
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    主要参考文献


    1: Pignatello R, Impallomeni G, Pistarà V, Cupri S, Graziano AC, Cardile V, Ballistreri A. New amphiphilic derivatives of poly(ethylene glycol) (PEG) as surface modifiers of colloidal drug carriers. III. Lipoamino acid conjugates with carboxy- and amino-PEG(5000) polymers. Mater Sci Eng C Mater Biol Appl. 2015 Jan;46:470-81. doi: 10.1016/j.msec.2014.10.054. Epub 2014 Oct 23. doi: 10.1039/c0cc02615h. Epub 2010 Nov 26. doi: 10.1016/j.jpba.2010.07.008. Epub 2010 Aug 1. doi: 10.1039/b811818c. Epub 2008 Sep 16.

    合成参考文献


    参考文献:10.1007/s00044-025-03434-0
    摘要:Shi R, Zhang P, Chen M, Lu W, Xu M, Zeng H, He J, Wang Y, Lin Y, Liu J. Dual-PROTACs based on natural product derivative potassium dehydrographolide succinate: design, synthesis, and antitumor activity of a novel EGFR degrader. Med Chem Res. 2025 Jun 30;34(8):1695–713. doi: 10.1007/s00044-025-03434-0.
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