CAS: 1198-27-2; 1-Aminonaphthalen-2-Ol Hydrochloride

相似化合物

550-60-7 5417-63-0 41772-23-0

上下游产品

sudan I 1-(pyridin-2-yl-azo)-2-naphthol orange II 1-benzylideneimino-2-naphthol 1-benzoylamino-2-benzoyloxy-naphthalene 1-benzamido-2-naphthol 2-phenyl-3H-naphtho[2,1-b][1,4]oxazin-3-one

Orange Ii置于sodium Dithionite,盐酸,Tin(Ll) Chloride体系中,用 水 用作溶剂,化学反应生成1-氨基-2-萘酚盐酸盐
参考文献:Synthesis,Characterization,In Vitro Anticancer Activity,And Docking Of Schiff Bases Of 4-Amino-1,2-Naphthoquinone
标题:Synthesis,Characterization,In Vitro Anticancer Activity,And Docking Of Schiff Bases Of 4-Amino-1,2-Naphthoquinone
摘要:A Series Of Schiff Bases Of 4-Amino-1,2-Naphthoquinone Were Synthesized,Purified,Characterized,And Evaluated For Cytotoxicity Against A Panel Of Human Cancer Cell Lines (Hep-G(2),Mg-63,And Mcf-7). The Cells Were Dosed With These Schiff Bases At Varying Concentrations,And Cell Viability Was Measured By A 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (Mtt) Assay. Significant Anticancer Activities Were Observed In Vitro For Some Members Of The Series And Compounds 4-(3,4,5-Trimethoxybenzylideneamino)Naphthalene-1,2-Dione (S10) As Well As 4-(4-Hydroxy-3-Methoxybenzylideneamino)Naphthalene-1,2-Dione (S13) Are Active Cytotoxic Agents Against Different Cancer Cell Lines With Ic50 Values In The Range Of 5.91-9.98 Mu M. The Structures Of Synthesized Compounds Were Established By Spectroscopic (Ft-Ir,H-1 NMR,C-13 NMR) And Elemental Analysis. To Study The Molecular Basis Of Interaction And Affinity Of Binding Of The Target Molecules,All The Compounds Were Docked Into The Atpase Domain Of Topoisomerase-Ii (Tp-Ii) By Using Schrodinger Molecular Modeling Software Package. Docking Experiments Showed A Good Correlation Between Their Predicted Glide Scores And The Observed Ic50 Values Of Synthesized Compounds. Structure-Activity Relationships Indicated That Presence Of Electron Donating Groups On Phenyl Ring Of Schiff Bases Enhances The Activity But Schiff Base With Electron Withdrawing Substituents On Phenyl Ring Shows Diminished Activity.
Doi:10.1007/s00044-012-0150-7

专利信息

专利号:US-7550510-B2
优先权日:2001-07-06
标 题 :Solid phase synthesis of arylretinamides
发明人：CURLEY JR ROBERT W; MERSHON SERENA M; BARNETT DEREK W; CLAGETT-DAME MARGARET; CHAPMAN JASON S
权利人:WISCONSIN ALUMNI RES FOUND
摘要:A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride; adding pyridine and a select arylamine to the resulting mixture; and stirring the resulting mixture for a time and at a temperature sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. Also provided, are select arylretinamides that can be prepared by the present method, and methods of using such arylretinamides to induce apoptosis in cancer cells.

专利号:US-2004102650-A1
优先权日:2001-07-06
标 题:Solid phase synthesis of arylretinamides

专利号:WO-9940093-A2
优先权日:1998-02-04
标题 :Synthesis of quinobenzoxazine analogues with topoisomerase ii and quadruplex interactions for use as antineoplastic agents

专利号:US-2003105164-A1
优先权日:2001-07-06
标 题 :Solid phase synthesis of arylretinamides

专利号:WO-03003987-A2
优先权日:2001-07-06
标题:Solid phase synthesis of arylretinamides