CAS: 1146-99-2; 2-(4-Chlorophenyl)-1H-Indene-1,3(2H)-Dione
该化合物是一种合成有机化合物,被归类为coumarin衍生物,主要以其用作抗凝胶剂而闻名,在医学领域,特别是在血栓性失调的管理方面,应用了药物,该化合物表现出黄色晶状,在有机溶剂中可溶解,但水中的溶解性有限.Clorindione功能通过抑制维生素Keperion REDANS,对肝脏中某些凝聚因素的合成至关重要,从而影响凝固层.其药用动力学包括口服生物利用率,在肝脏中代谢,其半衰期因个别病人因素而异.与许多抗凝胶剂一样,在使用血液凝固参数时,必须仔细监测血液凝固参数,以防止诸如出血等不利影响.
- 英文名称2-(4-Chlorophenyl)-1H-Indene-1,3(2H)-Dione
- 中文名称氯苯茚二酮
- IUPAC名称2-(4-chlorophenyl)-1H-indene-1,3(2H)-dione
- 其它别名1,3-Indandione,2-(p-chlorophenyl)- (6CI,7CI,8CI); 2-(4-Chlorophenyl)-1,3-indandione; 2-(p-Chlorophenyl)-1,3-indandione; Chlophenadione; Chlorathrombon; Chlorindion; Chlorindione; Chlorphenadione; Chlorphenindione; Clorindione; Indalitan; Indaliton
- CAS编号1146-99-2
- MFCD编号:MFCD00239203
- EINECS号:214-553-2
- FDA UNII编号:541C7WS64R
- 分子式:C15H9ClO2分子量:256.69
- 产品CID: 181072
- 产品分类生物化工 → 生化试剂 → 激动剂抑制剂
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
1,3-茚满二酮 1,3-Indandione 606-23-5合成工艺路线路线简述
- 合成目标产物 2-(4-Chlorophenyl)Indane-1,3-Dione 主要起始原料 Benzoyl Bromide And 4-Chlorobenzyl Cyanide
- (文献来源)合成步骤主要原料 Benzoyl Bromide 和 4-Chlorobenzyl Cyanide
📜(4-Chlorobenzyl)-(2-Bromophenyl)-Ketone置于盐酸,Lithium Tert-Butoxide体系中,用 四氢呋喃,1,4-二氧六环,水 用作溶剂,化学反应 4.5H,反应生成氯苯茚二酮
参考文献:Palladium-Catalyzed Chemoselective Synthesis Of Indane-1,3-Dione Derivatives Via Tert-Butyl Isocyanide Insertion
标题:Palladium-Catalyzed Chemoselective Synthesis Of Indane-1,3-Dione Derivatives Via Tert-Butyl Isocyanide Insertion
摘要:通过钯(0)催化的反应,利用叔丁基异氰基合成茚-1,3-二酮衍生物的简单高效策略已经开发出来.
Doi:10.1039/c5Ob00472A
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
2903919090-氯苯
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
专利号:KR-101513003-B1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy compositions and applications
专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:US-2008107598-A1
优先权日:2006-10-05
标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: King DA. A Trial of Clorindione-A Long Acting Oral Anticoagulant. Postgrad Med J. 1965 Dec;41(482):783-5.
合成参考文献
摘要:Schweizerische Medizinische Wochenschrift., 90(213), 1960 []
摘要:M. W. Whitehouse and J. E. Leader, Biochem. Pharmacol. 16, 537 (1967).
摘要:Y. Linaberg, O. Nieland, A. Veis and G. Vanag, Dokl. Chem. (Engl. Transl.) 154, 184 (1964).
摘要:W. Sztark, Diss. Pharm. Pharmacol. 19, 429 (1967); CA 68, 95569h.
📝 需求与反馈
尽可能描述清楚需求与问题信息
