CAS: 940-64-7; 2-(P-Tolyloxy)Acetic Acid

该化合物是一种有机化合物,具有芳香结构和功能组的特点,具有苯氧基组,是乙酸碱性的一个联苯环(特别是半替代甲基组),在室温下,该化合物一般是白色的,在白色和非白色固体,在有机溶剂中溶解,由于缺水芳香成分,溶解性在水中有限.它显示出箱酸的典型特性,包括溶液中捐赠质子(H+)的能力,有助于其酸性.在苯基环上存在的甲基组会影响其活动性和与生物系统的相互作用,使其在各种应用中,包括除草剂和药物中引起兴趣.安全数据表明,与许多有机化合物一样,它应该谨慎处理,因为它在接触皮肤或眼睛时可能会引起刺激.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号67028-40-4 (4-甲基苯氧基)乙酸乙酯 | CAS号106-44-5 对甲酚 | CAS号79-11-8 氯乙酸 | CAS号3926-62-3 氯乙酸钠 | CAS号38768-63-7 methyl (para-to... | CAS号1878-49-5 2-甲苯氧基乙酸 | CAS号2989-17-5 2-(2-methylphen... | CAS号95-48-7 邻甲酚 | CAS号1121-70-6 sodium p-cresolate | CAS号1878-94-0 4-碘苯氧基乙酸 | CAS号2021-04-7 2-(4-methylphen... | CAS号99-96-7 4-羟基苯甲酸 | CAS号2933-74-6 2-[(4-甲基苯基)氨基]乙醇 | CAS号33901-44-9 4-甲基苯氧基乙腈 | CAS号15516-47-9 (4-甲基苯氧基)乙酰氯 | CAS号126771-41-3 4-(溴甲基)苯氧基乙酸 | CAS号36304-39-9 对甲苯氧基乙酸肼 | CAS号3156-25-0 2-[(4-Methylphe... | CAS号35368-57-1 2-(4-methylphen... | CAS号15149-10-7 乙二醇单-对甲苯醚

合成工艺路线路线简述

  • 67028-40-4 = 940-64-7
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Tetrahydrofuran,Water; 3 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 1
    标题:High-Yielding Cleavage Of (Aryloxy) Acetates
    作者:Spurg,Anke; Waldvogel,Siegfried R.
    参考文献:European Journal Of Organic Chemistry 日期:2008 卷标:(2) 页码:337-342]

    67028-40-4 = 940-64-7
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Ethanol,Water; 12 H,Rt
    标题:Formononetin Derivative,Preparation Method,And Medicinal Use Thereof
    参考文献:China]

    = 940-64-7
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 30 Min,Heated; Cooled1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
    标题:Synthesis And Antimicrobial Activity Of Novel Pyrazolone And Pyrazole Analogues Containing Benzimidazole Moiety
    作者:Manjunath,G.; Bheemaraju,G.; Mahesh,M.; Ramana,P. Venkata
    参考文献:Research Journal Of Pharmaceutical 日期:2015 卷标:6(4) 页码:704-716]

    = 940-64-7
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 10 - 15 Min,Ph 9 - 10,Rt; Ph 9 - 10,Rt -> 90 °C; 3 H,Ph 9 - 10,80 - 90 °C
    标题:Synthesis And Biological Activities Of 1H-1,2,4-Triazole Derivatives Containing Aryloxyacetate Unit
    作者:Lu,Yan-Chang; Liu,Jian-Bing; Liang,Hua; Shi,Yan-Nian; Fang,Jian-Xin
    参考文献:Youji Huaxue 日期:2006 卷标:26(11) 页码:1571-1575]

    67028-40-4 = 940-64-7
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 2 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 1
    标题:Oxadiazole-Isopropylamides As Potent And Noncovalent Proteasome Inhibitors
    作者:Ozcan,Sevil; Kazi,Aslamuzzaman; Marsilio,Frank; Fang,Bin; Guida,Wayne C.; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2013 卷标:56(10) 页码:3783-3805]

    67028-40-4 = 940-64-7
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol; Overnight,Reflux
    标题:Preparation Of N-(Oxadiazolylmethyl) Phenoxy Acetamide Derivatives As Proteasome Inhibitors
    参考文献:World Intellectual Property Organization]

    15149-10-7 = 940-64-7
    反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: Platinum,Lead Nitrate,Cadmium Nitrate Solvents: Water; Rt -> 40 °C1.2 Reagents: Oxygen; 0.1 Mpa,40 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 1
    标题:Method For Preparation Of Aryloxycarboxylic Acid Raw Pesticide From Aryloxy Alcohol
    参考文献:China]

    = 940-64-7
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 3 H,90 - 95 °C1.2 Reagents: Hydrogen Ion Solvents: Water; Acidified
    标题:Synthesis And Herbicidal Activity Of N-(4,6-Dimethoxy-2-Pyrimidinyl)-2-(Aryloxy)Acetamide
    作者:Chu,Wenyi; Sun,Zhizhong; Gao,Jinsheng; Hou,Yanjun
    参考文献:Huaxue Shijie 日期:2005 卷标:46(12) 页码:741-744]

    = 940-64-7
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Potassium Iodide,Polyethylene Glycol Solvents: Dimethylformamide; 4 H1.2 Reagents: Sodium Hydroxide Solvents: Dimethylformamide,Water; 3 H1.3 Reagents: Hydrochloric Acid Solvents: Dimethylformamide,Water; Ph 3 - 4,Rt
    标题:A Rapid And High-Yield Synthesis Of Aryloxyacetic Acids In One Pot Under Microwave Irradiation And Phase Transfer Catalysis Conditions
    作者:Wei,Tai-Bao; Liu,Hong; Li,Man-Lin; Zhang,You-Ming
    参考文献:Indian Journal Of Chemistry 日期:2006 卷标:(5) 页码:1312-1314]

    = 940-64-7
    反应条件:1.1 Reagents: Sodium Carbonate,Potassium Iodide Solvents: Polyethylene Glycol1.2 -
    标题:Synthesis Of 5-Phenyl-N-[3-(3,4-Dimethyl-1H-Pyrrol-2-Yl)-5-Thioxo-4H-1,2,4-Triazol-4-Yl]-2-Furancarboxamide And 2-Phenoxy-N-[3-(3,4-Dimethyl-1H-Pyrrol-2-Yl)-5-Thioxo-4H-1,2,4-Triazol-4-Yl]Acetamide Derivatives
    作者:Xue,Si-Jia; Lu,Cheng-Liang
    参考文献:Youji Huaxue 日期:2008 卷标:28(6) 页码:1083-1086]

    67028-40-4 = 940-64-7
    反应条件:1.1 Reagents: Lithium Hydroxide Solvents: Tetrahydrofuran,Water
    标题:Boron-Containing Phenoxyacetanilide Derivatives As Hypoxia-Inducible Factor (Hif)-1α Inhibitors
    作者:Shimizu,Kazuki; Maruyama,Minako; Yasui,Yuka; Minegishi,Hidemitsu; Ban,Hyun Seung; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2010 卷标:20(4) 页码:1453-1456]

    = 940-64-7
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; Heated; Rt1.2 85 S,Heated1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 2 - 3,Rt
    标题:Microwave Irradiation-Promoted Synthesis Of Aryloxy Acetic Acids
    作者:Lin,Min; Zhou,Jin-Mei; Xia,Hai-Ping; Yang,Rui-Feng; Lin,Chen
    参考文献:Chemical Research In Chinese Universities 日期:2004 卷标:20(2) 页码:213-215]

    1878-94-0 + 993-15-7 = 940-64-7
    反应条件:1.1 Reagents: Potassium Hydroxide Catalysts: Palladium Chloride Solvents: Water
    标题:Palladium-Catalyzed Cross Coupling Of Organohalostannanes With Aryl Halides In Aqueous Medium
    作者:Bumagin,N. A.; Roshchin,A. I.
    参考文献:Russian Journal Of General Chemistry (Translation Of Zhurnal Obshchei Khimii) 日期:2000 卷标:70(1) 页码:57-63]

    67028-40-4 = 940-64-7
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Ethanol; 12 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Preparation Of Isoflavone Amide Derivatives For Treatment Of Hyperlipemia,Obesity Or Type 2 Diabetes
    参考文献:China]

    67028-40-4 = 940-64-7
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 8 H,Reflux; Cooled1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Cooled
    标题:Design,Docking,Synthesis,And Characterization Of Novel N'(2-Phenoxyacetyl) Nicotinohydrazide And N'(2-Phenoxyacetyl)Isonicotinohydrazide Derivatives As Anti-Inflammatory And Analgesic Agents
    作者:M,Pallavi H.; Al-Ostoot,Fares Hezam; Vivek,Hamse Kameshwar; Khanum,Shaukath Ara
    参考文献:Journal Of Molecular Structure 日期:2022 卷标:1247]

    = 940-64-7
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 3 H,Reflux; Reflux -> 60 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; 20 Min,Ph 5 - 6,60 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 1 - 2,Rt
    标题:Preparation Of Heterocyclic Oxyacetamide Herbicide
    参考文献:China]

    = 940-64-7
    反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: 1-Butanaminium,N,N-Dibutyl-N-Ethyl-,Ethyl Sulfate (1:1)
    标题:Synthesis Of Aryloxyacetic Acids Using Tributylethylammonium Ethylsulfate As Phase Transfer Catalyst
    作者:Li,Yiqun
    参考文献:Huaxue Shiji 日期:2000 卷标:22(1) 页码:47-48]

    67028-40-4 = 940-64-7
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; Ph 13; 1 H1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 4
    标题:Aryl-Substituted Piperazine Carbonyl Derivatives Useful In Treatment Of Ischemic Stroke And Their Preparation
    参考文献:China]

    38768-63-7 = 940-64-7
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Methanol; 60 Min,35 °C1.2 Reagents: Water1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 2
    标题:Facile Hydrolysis Of Esters With Koh-Methanol At Ambient Temperature
    作者:Khurana,Jitender M.; Chauhan,Sushma; Bansal,Geeti
    参考文献:Monatshefte Fuer Chemie 日期:2004 卷标:135(1) 页码:83-87]

    = 940-64-7
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 8 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
    标题:Some New Aryloxyacetic Acid
    作者:Shah,V. H.; Purohit,D. M.; Mehta,T. S.; Ravat,N. R.; Doshi,N. G.
    参考文献:Journal Of The Institution Of Chemists (India) 日期:2003 卷标:75(2) 页码:62-63
📜2-甲基苯氧基乙酸置于sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应 0.05H,反应生成 (4-甲基苯氧基)乙酸
参考文献:Wei,Tai-Bao; Liu,Hong; Li,Man-Lin,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,2006,Vol. 45,# 5,P. 1312-1314
标题:Wei,Tai-Bao; Liu,Hong; Li,Man-Lin,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,2006,Vol. 45,# 5,P. 1312-1314

海关参考信息

专利信息


专利号:WO-9002605-A1
优先权日:1988-09-02
标题:An apparatus and a method for the synthesis of peptides
发明人：MELDAL MORTEN; HOLM ARNE; BUCHARDT OLE
权利人:MELDAL MORTEN; HOLM ARNE; BUCHARDT OLE
摘要:An apparatus for use in chemical synthesis, especially peptide synthesis, comprises a synthesis chamber unit having a multiplicity of synthesis chambers, each of which has a liquid inlet and a liquid outlet, means for introducing liquid into the individual synthesis chambers and means for simultaneous removal of liquid via the liquid outlets of the synthesis chambers by regulation of the fluid pressure difference between the liquid inlets and the liquid outlets. A method for peptide synthesis using such an apparatus comprises the provision in each of the synthesis chambers of a solid-phase support material having a first, at least N-protected amino acid coupled thereto, after which a liquid deprotection reagent is introduced into the synthesis chambers. Following deprotection, the deprotection reagent is removed, after which a second, at least N-protected amino acid is introduced into each synthesis chamber in order to couple the first and second amino acids. Third, fourth, etc. amino acids may be coupled analogously. Complete removal of the deprotection reagent from the synthesis chambers and the support material can be ensured by incorporating a stable, intensely coloured dye, e.g., azorubin, in the deprotection reagent. The apparatus and the method make possible the parallel synthesis of a large number of peptides, e.g. peptides having overlapping amino acid sequences and constituting part of a longer peptide chain. The apparatus can be adapted to manual, semi-automatic or fully automatic performance of the various steps in the synthesis procedure.

专利号:US-5986132-A
优先权日:1995-11-18
标 题 :Synthesis of carboxylic acid derivatives
发明人：REEVE MAXWELL; BOWLES STEPHEN ARTHUR
权利人:BRITISH BIOTECH PHARM
摘要:Compounds of formula (I) wherein R 1 , R 2 , R 3 , R 4 , X are as defined in the specification and are prepared by elimination of one of the groups X 1 and X 2 from a compound of formula (II) wherein X 1 and X 2 each independently represent a carboxylic acid group or salt thereof, or a protected carboxylic acid group, the non-eliminated group X 1 or X 2 corresponding to the group X in the desired compound of formula (I). ##STR1##

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:WO-9719050-A1
优先权日:1995-11-18
标题:Synthesis of carboxylic acid derivatives

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摘要:Desroches, J.; Paquin, J.-F., Science of Synthesis Knowledge Updates, (2016) 1, 375.
摘要:Saha, D.; Aggarwal, T.; Sumii, Y.; Yadav, A. K.; Shibata, N., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2025) 2.
摘要:Das, A.; Ramkumar, N.; Veliks, J., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2025) 2.
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