CAS: 933-48-2; Cis-3,3,5-Trimethylcyclohexanol

该化合物是一种循环酒精,其独特的分子结构包括一个环环,有3个甲基组和一个氢氧组."cis"名称表明,3和5个位置上的氢氧基和两个甲基组位于环的同一侧,影响其立体化学和物理特性.该化合物通常是室内温度无色液体,由于存在可从事氢结合的氢化基体,水中存在中等溶解性.该化合物化学公式反映多种碳和氢原子的存在,有助于其疏水特性.该化合物对有机合成感兴趣,并可作为各种化学品生产的中间体.此外,其结构特征可影响其再活性和与其他物质的相互作用,使其与立体化学学和分子相互作用研究有关.应当参考安全数据,以便处理和使用,如同所有化学物质一样.

英文名称Cis-3,3,5-Trimethylcyclohexanol
中文名称Rac-(1r,5r)-3,3,5-三甲基环己烷-1-醇,顺式
IUPAC名称(1R,5R)-3,3,5-trimethylcyclohexan-1-ol
其它别名顺式-3,5,5-三甲基环己醇; Cis-3,5,5-Trimethylcyclohexanol
CAS编号933-48-2
MFCD编号:MFCD00070479
EINECS号:213-268-0
分子式:C9H18O分子量:142.24
产品CID: 1971638
产品分类有机原料→分子砌块→脂肪环类化合物→环己烷类化合物

相似结构搜索
InChIKey: BRRVXFOKWJKTGG-HGXVMFPFNA-N
InChI=1S/C9H18O/c1-7-4-8(10)6-9(2,3)5-7/h7-8,10H,4-6H2,1-3H3/t7-,8+/m0/s1
计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数*

相似化合物

116-02-9 767-12-4 767-54-4

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别皮肤腐蚀/刺激类别2
严重眼刺激类别2
水生慢性毒性类别3
严重眼损伤类别1
警示词Warning(警告)
危险描述H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H412 |对水生生物有害并具有长期持续影响.
H318 |造成严重眼损伤.
防范说明P264-P280-P302+P352-P362+P364
危险品标志Xi
安全声明39-26
危险类别码36

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

3,5,5-Trimethylcyclohex-2-en-1-one trans-3,3,5-trimethylcyclohexanol aluminum isopropoxide isopropyl alcohol3,5,5-trimethyl-cyclohexene cyclohexene, 3,3,5-trimethyl- 1,5,5-trimethylcyclohexene 3-bromo-1,1,5-trimethyl-cyclohexane

合成工艺路线路线简述

873-94-9 = 933-48-2
反应条件:1.1 Reagents: Bis(2-Methylpropyl)(2,2,2-Trifluoroacetato-Ko)Aluminum Solvents: Diethyl Ether; 72 H,25 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; 2 H,Rt
标题:Selective Reduction Of Organic Compounds With Al-Acetoxy- And Al-Trifluoroacetoxydiisobutylalane
作者:Cha,Jin Soon; Yi,Ja Eun
参考文献:Journal Of Inclusion Phenomena And Macrocyclic Chemistry 日期:2009 卷标:65(1-2) 页码:15-23]

873-94-9 = 933-48-2
反应条件:1.1 Reagents: Bis(2-Methylpropyl)(2-Propanolato)Aluminum Solvents: Diethyl Ether1.2 Reagents: Water
标题:Selective Reduction Of Carbonyl Compounds With Al-Alkoxydiisobutylalanes
作者:Cha,Jin Soon; Kwon,Oh Oun; Kim,Jong Mi; Chun,Joong Hyun; Lee,Young Soo; Et Al
参考文献:Bulletin Of The Korean Chemical Society 日期:1998 卷标:19(2) 页码:236-242]

873-94-9 = 933-48-2
反应条件:1.1 Reagents: Bis(2-Methylpropyl)(2-Propanolato)Aluminum Solvents: Diethyl Ether
标题:Reexamination Of Al-Isopropoxydiisobutylalane As A Stereoselective Reducing Agent For Reduction Of Cyclic Ketones To Thermodynamically More Stable Alcohols
作者:Cha,Jin Soon; Kwon,Oh Oun
参考文献:Bulletin Of The Korean Chemical Society 日期:1997 卷标:18(7) 页码:689-690]

78-59-1 = 933-48-2
反应条件:1.1 Reagents: Lithium,Ferrous Chloride Tetrahydrate Catalysts: 4,4′-Bis(1,1-Dimethylethyl)-1,1′-Biphenyl Solvents: Tetrahydrofuran; 5 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Diethyl Ether,Water
标题:New Active-Iron Based Reducing System For Carbonyl Compounds And Imines. Stereoselective Reduction Of Cyclic Ketones
作者:Moglie,Yanina; Alonso,Francisco; Vitale,Cristian; Yus,Miguel; Radivoy,Gabriel
参考文献:Tetrahedron 日期:2006 卷标:62(12) 页码:2812-2819]

= 933-48-2
反应条件:1.1 Reagents: Hydrochloric Acid
标题:Introduction Of An O-Ethoxymethyl Group To Protect The Hydroxy Group In Alcohols And Phenols
作者:Schaper,Ulf Armin
参考文献:Synthesis 日期:1981 卷标:(10) 页码:794-6]

873-94-9 = 933-48-2
反应条件:1.1 Reagents: Lithium,Ferrous Chloride Tetrahydrate Solvents: Tetrahydrofuran; Rt; 1 H,Rt; Cooled1.2 Reagents: Water
标题:The Stereoselective Reductions Of Ketones To The Most Thermodynamically Stable Alcohols Using Lithium And Hydrated Salts Of Common Transition Metals
作者:Kennedy,Nicole; Cohen,Theodore
参考文献:Journal Of Organic Chemistry 日期:2015 卷标:80(16) 页码:8134-8141]

78-59-1 = 933-48-2
反应条件:1.1 Reagents: Lithium,Nickel Dichloride Catalysts: 4,4′-Bis(1,1-Dimethylethyl)-1,1′-Biphenyl Solvents: Tetrahydrofuran; 10 Min,Rt1.2 Reagents: Isopropanol Solvents: Isopropanol; Rt -> 76 °C; 1 H,76 °C
标题:Hydrogen-Transfer Reduction Of Carbonyl Compounds Promoted By Nickel Nanoparticles
作者:Alonso,Francisco; Riente,Paola; Yus,Miguel
参考文献:Tetrahedron 日期:2008 卷标:64(8) 页码:1847-1852]

470-99-5 = 933-48-2
反应条件:1.1 Reagents: Hydrogen Catalysts: Iridium(1+),[(1,2,5,6-η)-1,5-Cyclooctadiene](Pyridine)(Tricyclohexylphosphine)-... Solvents: Dichloromethane
标题:Directing Effects In Homogeneous Hydrogenation With [ir(Cod)(Pcy3)(Py)]Pf6
作者:Crabtree,Robert H.; Davis,Mark W.
参考文献:Journal Of Organic Chemistry 日期:1986 卷标:51(14) 页码:2655-61]

873-94-9 = 933-48-2
反应条件:1.1 Reagents: Sodium Carbonate,β-Cyclodextrin Hydrogen Sulfate Sodium Salt Solvents: Water; 16 H,Rt1.2 Reagents: Sodium Borohydride; Rt
标题:The Effect Of β-Cyclodextrin On The Diastereoselective Nabh4 Reduction Of Cyclohexanone Derivatives
作者:Seo,Myung Soo; Lee,Sang Hee
参考文献:Bulletin Of The Korean Chemical Society 日期:2006 卷标:27(5) 页码:783-785]

873-94-9 = 933-48-2
反应条件:1.1 Reagents: Aluminum Hydride Solvents: Tetrahydrofuran1.2 Reagents: Hydrochloric Acid Solvents: Water
标题:Reexamination Of Aluminum Hydride As A Stereoselective Reducing Agent For Reduction Of Cyclic Ketones To Thermodynamically More Stable Alcohols
作者:Cha,Jin Soon; Moon,Suk Joung; Kwon,Oh Oun; Lee,Yong Rok
参考文献:Bulletin Of The Korean Chemical Society 日期:2000 卷标:21(1) 页码:128-130]

767-54-4 = 933-48-2 + 873-94-9
反应条件:1.1 Reagents: 2,5-Dimethyl-2,5-Hexanediol,Nickel Acetate,Sodium Hydride Solvents: Tetrahydrofuran
标题:Activation Of Reducing Agents. Sodium Hydride-Containing Complex Reducing Agents. 29. Epimerization Of Alcohols By Nickel-Containing Complex Reducing Agents (Nicra)
作者:Feghouli,G.; Et Al
参考文献:Tetrahedron Letters 日期:1988 卷标:29(12) 页码:1383-4]

873-94-9 = 933-48-2
反应条件:1.1 Reagents: (Methanesulfonato-Ko)Bis(2-Methyl-1-Propanolato)Aluminum Solvents: Diethyl Ether,Tridecane; 72 H,25 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; 2 H,25 °C
标题:Selective Reduction Of Organic Compounds With Al-Methanesulfonyldiisobutylalane
作者:Cha,Jin Soon; Noh,Minyeong
参考文献:Bulletin Of The Korean Chemical Society 日期:2010 卷标:31(4) 页码:840-844]

873-94-9 = 933-48-2
反应条件:1.1 Reagents: Aluminate(1-),(Cyano-Kc)Trihydro-,Sodium (1:1),(T-4)- Solvents: Tetrahydrofuran; 0.5 H,0 °C1.2 Reagents: Hydrochloric Acid Solvents: Water
标题:Reaction Of Sodium Cyanoaluminum Hydride With Selected Organic Compounds Containing Representative Functional Groups
作者:Cha,Jin Soon; Yu,Se Jin; Roh,Min Young; Yi,Ja Eun; Park,Seung Jin; Et Al
参考文献:Bulletin Of The Korean Chemical Society 日期:2008 卷标:29(12) 页码:2379-2382]

873-94-9 = 933-48-2
反应条件:1.1 Reagents: Bis(2-Methylpropyl)(2-Propanolato)Aluminum Solvents: Diethyl Ether1.2 Reagents: Hydrochloric Acid Solvents: Water
标题:Al-Isopropoxydiisobutylalane. A Stereoselective Reducing Agent For Reduction Of Cyclic Ketones To Thermodynamically More Stable Alcohols
作者:Cha,Jin Soon; Kwon,Oh Oun
参考文献:Journal Of Organic Chemistry 日期:1997 卷标:62(9) 页码:3019-3020]

873-94-9 = 933-48-2
反应条件:1.1 Reagents: Aluminum,Bis(2-Methylpropyl)-1H-Pyrrol-1-Yl- Solvents: Diethyl Ether1.2 Reagents: Hydrochloric Acid Solvents: Water
标题:1-Pyrrolyldiisobutylalane. A Stereoselective Reducing Agent For Reduction Of Cyclic Ketones To Thermodynamically More Stable Alcohols
作者:Kwon,Oh Oun; Cha,Jin Soon
参考文献:Bulletin Of The Korean Chemical Society 日期:2000 卷标:21(6) 页码:659-661]

873-94-9 = 933-48-2
反应条件:1.1 Reagents: Diisobutylaluminum Hydride Solvents: Diethyl Ether
标题:Reexamination Of Diisobutylaluminum Hydride As A Stereoselective Reducing Agent For Reduction Of Cyclic Ketones To Thermodynamically More Stable Alcohols
作者:Cha,Jin Soon; Kwon,Oh Oun; Kim,Jong Mi; Cho,Sun Dong
参考文献:Synlett 日期:1997 卷标:(12) 页码:1465-1466]

873-94-9 = 933-48-2
反应条件:1.1 Solvents: Tetrahydrofuran1.2 Reagents: Water,Borate(1-),1,5-Cyclooctanediyl(1,1-Dimethylethyl)Hydro-,Potassium,(T-4)-1.3 Reagents: Potassium Carbonate,Hydrogen Peroxide Solvents: Tetrahydrofuran
标题:Preparation Of Potassium 9-Alkyl-9-Boratabicyclo[3.3.1]Nonanes And Their Stereoselectivity In The Reduction Of Cyclic Ketones
作者:Cha,Jin Soon; Yoon,Mal Sook; Lee,Kwang Woo; Lee,Jae Cheol
参考文献:Heterocycles 日期:1988 卷标:27(6) 页码:1455-60]

873-94-9 = 933-48-2
反应条件:1.1 Reagents: Borate(1-),1,5-Cyclooctanediyl(1,1-Dimethylethyl)Hydro-,Potassium,(T-4)- Solvents: Tetrahydrofuran
标题:A New Class Of Stereoselective Reducing Agents,Potassium 9-Alkyl-9-Boratabicyclo[3.3.1]Nonanes
作者:Cha,Jin Soon; Yoon,Mal Sook; Kim,Young Shick; Lee,Kwang Woo
参考文献:Tetrahedron Letters 日期:1988 卷标:29(9) 页码:1069-70]

873-94-9 = 933-48-2
反应条件:1.1 Reagents: Sodium Borohydride Solvents: Ethanol; 4 H,Reflux
标题:Surface Modified Nano Fly Ash As An Activator In The Reduction Of Ketones
作者:Dash,Subhajit; Chaudhuri,Haribandhu; Viswakarma,Sangita; Sarkar,Ashis
参考文献:Journal Of Nanoscience And Nanotechnology 日期:2018 卷标:18(6) 页码:4282-4287]

78-59-1 = 933-48-2
反应条件:1.1 Reagents: 2-Amino-5-Chlorobenzoic Acid; Rt -> 0 °C1.2 Reagents: Lithium; 120 Min,0 °C; 90 Min,0 °C; 50 Min,0 °C -> 16 °C1.3 Reagents: Dimethylamine,Oxalic Acid,Potassium Bromide; 16 °C
标题:Method For Synthesizing Cis-3,3,5-Trimethylcyclohexanol As Intermediate Of Cyclandelate Drug
参考文献:China]

873-94-9 = 933-48-2
反应条件:1.1 Reagents: Hydrogen Catalysts: Ruthenium1.2 Catalysts: P-Toluenesulfonic Acid Solvents: Toluene
标题:Preparation Of Cis-3,3,5-Trimethylcyclohexanol
参考文献:Japan