CAS: 79-81-2; (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-Trimethylcyclohex-1-En-1-yl)Nona-2,4,6,8-Tetraen-1-Yl Palmitate

上下游产品

CAS号112-39-0 棕榈酸甲酯 | CAS号127-47-9 维生素A醋酸酯 | CAS号57-10-3 棕榈酸 | CAS号110-86-1 吡啶 | CAS号68-26-8 视黄醇 | CAS号112-67-4 棕榈酰氯 | CAS号4759-48-2 异维A酸 | CAS号302-79-4 维生素A酸； 视黄酸

β-Cyclogeranyl Chloride置于sodium Methylate,Sodium Ethanolate,Sodium Hydroxide体系中,用 二氯甲烷,水,N,N-二甲基甲酰胺,乙腈 作为反应溶剂,化学反应 19.0H,反应生成 维生素 A 棕榈酸酯
参考文献:一种维生素a酯中间体c15及维生素a酯的制备方法
标题:一种维生素a酯中间体c15及维生素a酯的制备方法
摘要:本发明提供一种维生素a酯中间体c15及维生素a酯的制备方法.该方法以3,7‑二甲基‑3‑羟基‑1,6‑辛二烯为起始原料,经卤代反应,环化反应,然后和三苯基膦或亚磷酸三酯经取代反应制备相应wittig试剂,然后和2‑甲基‑4‑乙酰氧基‑2‑丁烯醛经wittig反应,酸化,所得产物经水解和酸化,再和三苯基膦或亚磷酸三酯经取代反应制备c15.利用所得c15和2‑甲基‑4‑r3取代基羰基氧基‑2‑丁烯醛经wittig反应可制备维生素a酯.本发明方法反应类型单一,反应条件易于操作和实现,操作安全环保,后处理简单,成本较低;反应活性强,反应选择性高,原子经济性高,目标产物收率和纯度高.

专利信息

专利号:US-8722852-B2
优先权日:2006-04-28
标 题 :Cosmetic composition for stimulating the synthesis of proteins of the basement membrane
发明人：ZIEGLER HUGO; IMFELD DOMINIK; STOCKLI MARTIN; HEIDL MARC
权利人:ZIEGLER HUGO; IMFELD DOMINIK; STOCKLI MARTIN; HEIDL MARC; DSM IP ASSETS BV
摘要:Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R 1 is H, C 1 -C 20 -alkyl, cycloalkyl or aryl-C 1 -C 4 -alkyl, n is 1-4, X is —O—, —NH— or —NR 2 — and R 2 H or C 1 -C 20 -alkyl; and at least one compound corresponding to the above formula (I) but in which XR 1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is —NR 2 — and both R 1 and R 2 are different from H, and the compounds corresponding to formula (I) but in which XR 1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid, as such.

专利号:WO-2024263718-A1
优先权日:2023-06-23
标 题:Synthesis of (-)-trans-δ9-tetrahydrocannabivarin and analogs thereof
发明人：ROGGEN MARKUS; SAMMIS GLENN M; ROBERTS MATTHEW
权利人:NALU BIO INC
摘要:A method is provided for the synthesis of (-)-trans-Δ9-tetrahydrocannabivarin (Δ9-THCV) and analogs thereof starting from a resorcinol reactant, such as divarinol, and a p-menthadienol reactant and proceeding through Δ8-THCV as intermediate. The initial step of the reaction between the resorcinol reactant and the p-menthadienol reactant is carried out in a solvent at elevated temperature in the presence of a Brønsted acid to form the Δ8 isomer. The Δ8 double bond is halogenated and the halogenated intermediate thus formed treated with a strong base to effect dehydrohalogenation and provide the desired product, Δ9-THCV, in high yield, with minimal or no remaining Δ8-THCV.

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:WO-2015183067-A1
优先权日:2014-05-30
标题 :Synthesis of analogues of y-amino acids and resulting products
发明人：FERNÃ?NDEZ ZERTUCHE MARIO; TOVAR GUDIÑO ERIKA; TRUJILLO FERRARA JOSÉ GUADALUPE; GUEVARA SALAZAR JUAN ALBERTO
权利人:UNIV AUTÓNOMA DEL ESTADO DE MORELOS
摘要:The invention relates to a compound of formula (see formula), suitable for use as drugs in the treatment of chronic neurodegenerative disorders of the Huntington's disease, Parkinson's disease and epilepsy type, inter alia . The invention relates to novel methods for the synthesis of said analogues and the pharmaceutically acceptable solvates and salts thereof.

专利号:US-9579267-B2
优先权日:2011-07-14
标 题:Cosmetic with enhanced collagen I synthesis
发明人：DOUCET OLIVIER; BERNINI DOROTHEE; ROBERT CECILE; PUJOS MURIEL
权利人:DOUCET OLIVIER; BERNINI DOROTHEE; ROBERT CECILE; PUJOS MURIEL; COTY GERMANY GMBH
摘要:A cosmetic including two different systems for procurement of actives in the human skin and enhancing the collagen I synthesis. The cosmetic with enhanced collagen I synthesis can include 0.001 to 2% by weight, related to the total weight of the cosmetic, of a first retinol-containing system including retinol encapsulated in a chitosan and carboxymethyl cellulose shell, 0.001 to 3.5% by weight, related to the total weight of the cosmetic, of a second retinol-containing system including cationic liposomes composed of phospholipids and with a quaternary fatty acid monoamine with C 21 -C 23 alkyl residue and the difference to 100% by weight of cosmetic subsidiaries. Very small amounts of retinol in combination with both transport systems show a remarkable effect on the synthesis of collagen I in comparison with one or more other known combinations of retinol derivatives or encapsulated systems.