CAS: 762287-59-2; 3-Fluoro-2-Methoxyphenylboronic Acid

在 盐酸体系中,化学反应生成 2-甲氧基-3-氟苯硼酸
参考文献:Substituted 3-Amino Biaryl Propionic Acids As Potent Vla-4 Antagonists
标题:Substituted 3-Amino Biaryl Propionic Acids As Potent Vla-4 Antagonists
摘要:A Series Of Substituted N-(3,5-Dichlorobenzenesulfonyl)-(L)-Prolyl-And (L)-Azetidyl-Beta-Biaryl Beta-Alanine Derivatives Was Prepared As Selective And Potent Vla-4 Antagonists. The 2,6-Dioxygenated Biaryl Substitution Pattern Is Important For Optimizing Potency. Oral Bioavailability Was Variable And May Be A Result Of Binding To Circulating Plasma Proteins. (C) 2002 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0960-894X(02)00460-2

专利信息

专利号:CN-103384663-B
优先权日:2010-12-23
标题:Synthesis of intermediates for the preparation of anacetrapib and derivatives thereof

专利号:US-2025026766-A1
优先权日:2022-01-12
标题 :Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors
发明人：LI JING; XU WENQING; WANG ZHIWEI
权利人:BEIGENE LTD
摘要:The present invention relates to compounds containing thiazolopyridyl amide structure, the process for their synthesis, as well as the use of such compounds for inhibiting DNA Polymerase Theta (Pol Theta), and in the treatment of various diseases including cancers.

专利号:US-9951062-B2
优先权日:2012-12-14
标 题 :Substituted 1 H-pyrrolo [2, 3-b] pyridine and 1 H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
发明人：VANKAYALAPATI HARIPRASAD; YERRAMREDDY VENKATAKRISHNAREDDY; GANIPISETTY VENU BABU; TALLURI SURESHKUMAR; APPALANENI RAJENDRA P
权利人:ARRIEN PHARMACEUTICALS LLC
摘要:Compounds according to Formulas I, IA or IB: n nto pharmaceutically acceptable composition, salts thereof, their synthesis and their use as SIK2 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and/or disorders such as cancer, stroke, cardiovascular, obesity and type II diabetes.

专利号:US-9834551-B2
优先权日:2013-04-18
标 题 :Substituted pyrrolo[2,3-b]pyrazines and substituted pyrazolo[3,4-b]pyridines as ITK and JAK kinase inhibitors
发明人：VANKAYALAPATI HARIPRASAD; YERRAMREDDY VENKATAKRISHNAREDDY; GANGIREDDY PARAMAREDDY; APPALANENI RAJENDRA P
权利人:ARRIEN PHARMACEUTICALS LLC
摘要:The present invention relates to compounds described by Formula I: n nsalts thereof, their synthesis, and their use as ITK and JAK3 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and or disorders such disease associated with abnormal cell growth such as autoimmune, inflammation, rheumatoid arthritis, systemic lupus erythematosus, atherosclerosis, ulcerative colitis, psoriatic arthritis, psoriasis, Crohn's, metabolic and cancer diseases. The present invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions and processes for preparing the compounds of the invention.