CAS: 73291-09-5; 4-(Chloromethyl)Benzaldehyde

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CAS号16473-35-1 4-(氯甲基)苯甲基醇 | CAS号142651-25-0 [4-(1,3-dioxola... | CAS号1592-20-7 对氯甲基苯乙烯 | CAS号52889-83-5 4-(甲氧甲基)氯苄 | CAS号874-86-2 4-氰基苄氯 | CAS号1571-08-0 对甲酰基苯甲酸甲酯 | CAS号589-29-7 对苯二甲醇 | CAS号51359-78-5 4-溴甲基苯甲醛 | CAS号52010-97-6 对羟甲基苯甲醛 | CAS号1592-20-7 对氯甲基苯乙烯 | CAS号731846-75-6 (E)-甲基3-(4-(氯甲基... | CAS号93943-06-7 4-(甲氧基甲基)苯甲醛

4-(甲氧甲基)氯苄置于硝酸体系中,用 二氯甲烷 作为反应溶剂,化学反应 1.0H,以91%的收率获得产物4-(氯甲基)苯甲醛
参考文献:硝酸在二氯甲烷中将苯甲醇和醚氧化成羰基衍生物
标题:硝酸在二氯甲烷中将苯甲醇和醚氧化成羰基衍生物
摘要:二氯甲烷中的硝酸可成功用于将苄醇和醚氧化成相应的羰基化合物.所提出的方法被证明具有普遍适用性,醛和酮的收率非常好,并且在许多情况下显示出有趣的化学选择性,可以避免竞争性芳香硝化,以及-在醛的情况下-任何进一步氧化成羧酸. 该反应可能通过自由基机制进行,氧化过程中的活性物质是 No2.在某些情况下观测到硝基酯的竞争性形成,而使用烯丙基和非苄基底物获得的结果不佳.(© Wiley-Vch Verlag Gmbh & Co. Kgaa,69451 Weinheim,Germany,2003)
DOI:10.1002/ejoc.200390090

专利信息

专利号:US-2024261416-A1
优先权日:2023-01-31
标题:Synthesis of novel cereblon e3 ligase ligands, compounds formed thereby, and pharmaceutical compositions containing them
发明人：TANG WEIPING; XIE HAIBO; WU YUNXIANG; LIAO JUNZHUO; LI CHUNRONG; TANDON IRA; TANG HUA
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Provided herein are achiral cereblon (CRBN) ligands based on phenyl dihydrouracil that have optimal binding to CRBN without having chiral carbons. Also provided herein are the proteolysis targeting chimeras (PROTACs) comprising the CRBN ligands and a protein binder, pharmaceutical compositions containing the PROTACs, and methods of treating diseases using the PROTACs.

专利号:US-2011143967-A1
优先权日:2009-12-15
标 题:Surface modifications and methods for their synthesis and use
发明人：MCGALL GLENN H; BARONE ANTHONY D; TRUE RANDALL J
权利人:MCGALL GLENN H; BARONE ANTHONY D; TRUE RANDALL J
摘要:Novel processes are disclosed for forming an array of polymers by functionalizing the surface of particles by methods that include covalently attaching a functionalized silicon compound. Substrates such as microparticles having functionalized silicon compounds attached thereto are produced by introducing at least one carboxyl group directly by silanating a carboxylated silane compound to the surface of a microparticle. In a further aspect of the invention, the silane compound is a dipodal carboxylated silane.

专利号:US-4665080-A
优先权日:1984-07-06
标 题 :Imidazolyl compounds and their use as medicaments
发明人：WESS GUENTHER; BARTMANN WILHELM; BECK GERHARD; LAU HANS-HERMANN
权利人:HOECHST AG
摘要:The present invention relates to new ortho-, meta- and para-substituted imidazolylmethylstyrenes of the formula I I and to a process for their preparation. The compounds according to the invention are distinguished by having a specific inhibitory effect on the synthesis of thromboxane, and hence they can be used as medicaments.

专利号:US-9925213-B2
优先权日:2010-03-19
标 题:Nylon-3 co-polymers and synthetic lung surfactant compositions containing same
发明人：GELLMAN SAMUEL H; STAHL SHANNON S; MOWERY BRENDAN P; BARRON ANNELISE; DOHM MICHELLE
权利人:WISCONSIN ALUMNI RES FOUND; UNIV NORTHWESTERN
摘要:Non-natural oligomers have recently shown promise as functional analogs of lung surfactant proteins B and C (SP-B and SP-C), two helical and amphiphilic proteins that are critical for normal respiration. The generation of non-natural mimics of SP-B and SP-C has previously been restricted to step-by-step, sequence-specific synthesis, which results in discrete oligomers that are intended to manifest specific structural attributes. Presented herein an alternative approach to SP-B mimicry that is based on sequence-random copolymers containing cationic and lipophilic subunits. These materials, members of the nylon-3 family, are prepared by ring-opening polymerization of β-lactams. The best of the nylon-3 polymers display promising in vitro surfactant activities in a mixed lipid film. Pulsating bubble surfactometry data indicate that films containing the most surface-active polymers attain adsorptive and dynamic-cycling properties that surpass those of discrete peptides intended to mimic SP-B. Attachment of an N-terminal octadecanoyl unit to the nylon-3 copolymers affords further improvements by reducing the percent surface area compression to reach low minimum surface tension.

专利号:CN-113567380-B
优先权日:2021-07-26
标 题 :A kind of benzyl chloropyridinium salt derivative as pH indicator and its synthesis method

专利号:CN-109053527-A
优先权日:2018-07-27
标 题:Synthesis method and application of a kind of polymer cationic bleach activator