CAS: 6877-32-3; Corynoxine

上下游产品

19H26N2O4C19H26N2O4 tert-butyl 2-oxohex-5-enoate tryptamine tert-butyl 2,5-dioxopentanoate

📜在 Palladium 10% On Activated Carbon,氢气,三氟乙酸,三氟乙酸酐体系中,用 四氢呋喃,二氯甲烷,乙酸乙酯 作为反应溶剂,-78.0~20.0 °C,101.33 Kpa 条件下,反应 46.08H,反应生成 柯诺辛
参考文献:螺环羟吲哚生物碱棒碱,棒棒碱 B,棒棒碱和钩藤碱的全合成
标题:螺环羟吲哚生物碱棒碱,棒棒碱 B,棒棒碱和钩藤碱的全合成
摘要:报道了四种螺环羟吲哚生物碱的外消旋全合成.一般的起始材料是 N-2-丁烯基化的 2-羟色胺,它与官能化的醛进行碱介导的曼尼希螺环化反应以反应生成 C 环.第二个关键步骤是 Pd 催化的 α-酮酯烯醇化物(在原始醛中)环化到烯丙基碳酸酯(在 N 取代基中)以形成 D 环.关键步骤的立体选择性适中,但异构体易于纯化,可以方便地制备天然产物,其中三个是首次.
DOI:10.1002/ejoc.201201505

专利信息

专利号:US-2025092433-A1
优先权日:2023-09-20
标 题:Polypeptides for use in the synthesis of kratom alkaloids
发明人：CASARETTO JOSE; AKTAR TARIQ A; ROTHSTEIN STEVEN; SOUBEYRAND ERIC
权利人:MITRADYNE CORP
摘要:Described herein are polypeptides encoding enzymes for the synthesis of monoterpene indole alkaloids. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1-68, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1-68, or a fragment of the polypeptide, or the variant thereof.

专利号:US-9604987-B2
优先权日:2011-03-23
标题 :Synthesis of autophagy inducing compound and the uses thereof
发明人：LI MIN; Liu liang feng; SONG JU XIAN; Zhang hong jie
权利人:UNIV HONG KONG BAPTIST UNIV
摘要:The present invention relates to a composition comprising compound of formula CB6 or CB8, n nthe pharmaceutically-acceptable carrier, solvent, the salts thereof or a combination thereof which is used to treat autophagy-associated diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, etc. The present invention also relates to a method of treating these diseases by administering a therapeutically-effective amount of the compound to the subject in need of the treatment. The present invention further relates to the use of this compound in preparation of the composition to treat the diseases.

专利号:EP-4538367-A2
优先权日:2023-09-20
标 题:Polypeptides for use in the synthesis of kratom alkaloids

专利号:US-2016046629-A1
优先权日:2011-03-23
标题:Synthesis of autophagy inducing compound and the uses thereof