CAS: 67219-55-0; N-(1-((2R,4S,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Hydroxytetrahydrofuran-2-yl)-2-Oxo-1,2-Dihydropyrimidin-4-yl)Benzamide

相似化合物

104579-03-5 81246-76-6 110764-74-4

上下游产品

CAS号40615-36-9 4,4'-二甲氧基三苯基氯甲烷 | CAS号4836-13-9 N4-苯甲酰基-2'-脱氧胞苷 | CAS号951-77-9 2’-脱氧胞苷 | CAS号118352-74-2 5'-O-(4,4'-dime... | CAS号98-88-4 苯甲酰氯 | CAS号3992-42-5 2'-脱氧胞苷盐酸盐 | CAS号65-85-0 苯甲酸 | CAS号31501-22-1 N,3'-O,5'-O-Tri... | CAS号4836-13-9 N4-苯甲酰基-2'-脱氧胞苷 | CAS号74405-44-0 5'-O-(4,4'-DIME... | CAS号76512-82-8 5'-O-(4,4'-DIME... | CAS号807369-63-7 N4-(3-aminoprop... | CAS号6220-63-9 2ˊ-脱氧胞苷-3ˊ-一磷酸

2'-脱氧胞苷盐酸盐置于sodium Hydroxide体系中,用 四氢呋喃,吡啶,甲醇,水 作为反应溶剂,化学反应 18.17H,反应生成 N4-苯甲酰基-5'-O-(4,4'-二甲氧基三苯基)-2'-脱氧胞苷
参考文献:四个十氧代核糖核苷酸的简化液相制备及其初步光谱表征
标题:四个十氧代核糖核苷酸的简化液相制备及其初步光谱表征
摘要:Daptpaptpaptpaptpapt,Daptpaptpcpgpaptpapt和dapapapapapapapapaptptptly化学合成了四个自互补的十氧杂核糖核苷酸daptpaptpaptpaptpapt,Daptpaptpcpgpcpaptpaptply.努力集中于使过程尽可能简单,同时在该过程的每个步骤中获得高纯度的产品.根据以下方案,从3'-末端以3'-O-苯甲酰化的单体开始精加工十聚体:单体+单体二聚体+二聚体四聚体+二聚六聚体+四聚体十聚体.中间体和完全封闭的十聚体的纯度通过色谱法和300Mhz 1 Hn M R.光谱法进行监测.解封闭的十氧杂核糖核苷酸的特征在于它们的uv,Cd和1 HNMR.光谱.
DOI:10.1002/hlca.19820650803

专利信息

专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人：XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.

专利号:US-4849513-A
优先权日:1983-12-20
标 题 :Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
发明人：SMITH LLOYD M; FUNG STEVEN; KAISER ROBERT J
权利人:CALIFORNIA INST OF TECHN
摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

专利号:US-12337291-B2
优先权日:2017-09-11
标 题 :Guide RNA synthesis system and method
发明人：DABROWSKI PAUL; GERLINGHAUS FABIAN; KELSO REED; WALKER II JOHN ANDREW
权利人:SYNTHEGO CORP
摘要:The present invention provides improved automated systems and methods for synthesis of biopolymers including DNA and RNA. The automated systems and methods represent a number of improvements over existing systems for multiplex synthesis of biopolymers in a combinatorial fashion.

专利号:US-5118800-A
优先权日:1983-12-20
标 题 :Oligonucleotides possessing a primary amino group in the terminal nucleotide
发明人：SMITH LLOYD M; FUNG STEVEN; KAISER JR ROBERT J
权利人:CALIFORNIA INST OF TECHN
摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

专利号:WO-0127126-A1
优先权日:1999-10-14
标题 :Process for the preparation of phosphorothioate triesters and oligonucleotides
发明人：DOUGLAS MARK EDWARD; SCOTT KEVIN GERARD
权利人:AVECIA LTD; DOUGLAS MARK EDWARD; SCOTT KEVIN GERARD
摘要:A process for the synthesis of a phosphorothioate triester is provided. The process comprises the reaction, in the presence of a coupling agent, of an H-phosphonate with a substrate comprising a free hydroxy group and bonded to a solid support, thereby forming a supported H-phosphonate diester, and subjecting the H-phosphonate diester to sulphur transfer with a sulphur transfer agent.

专利号:US-5015733-A
优先权日:1983-12-20
标题 :Nucleosides possessing blocked aliphatic amino groups
发明人：SMITH LLOYD M; FUND STEVEN; KAISER JR ROBERT J
权利人:CALIFORNIA INST OF TECHN
摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieites may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.