专利号:US-10253153-B2 优先权日:2015-04-24 标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support 发明人:MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI 权利人:NITTO DENKO CORP 摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.
专利号:US-10730904-B2 优先权日:2012-11-14 标 题:Method for liquid-phase synthesis of nucleic acid 发明人:NONOGAWA MITSURU; NAGATA TOSHIAKI; SAITO HIDEKI; YASUMA TSUNEO 权利人:TAKEDA PHARMACEUTICALS CO 摘要:In this method, an oligonucleotide represented by formula (II) [wherein Y 1 , Q, Base, r and r′ are each as defined in claim 1 ] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.
专利号:EP-3560936-A1 优先权日:2018-04-24 标题:Method for the synthesis of alkenyl-phosphorous compounds 发明人:SCHÄFER SASCHA WILHELM; ZHAO LIGANG; STUDER AMIDO 权利人:HENKEL AG & CO KGAA 摘要:The invention pertains to a method for the synthesis of specific alkenyl-phosphorous compounds according to formula (I)whereinR1and R2are independently selected from hydrogen or a substituted or unsubstituted C1-40hydrocarbon group, whereby the group optionally contains at least one heteroatom, preferably O, N or S;X is independently O or S;R3and R4are independently selected from a substituted or unsubstituted C1-40hydrocarbon group, whereby the group optionally contains at least one heteroatom, preferably O, N or S;m is independently 0 or 1; andn is an integer from 1 to 4. Furthermore, the invention relates to compounds obtained by this method, and compositions comprising the compounds of the present invention, wherein the compositions are compositions for lighting applications, optical applications, microelectronic compounds, optical brighteners or are detergent compositions. Finally, the invention relates to the use of the compounds of the present invention in lighting lighting applications, optical applications microelectronic compounds, optical brighteners or detergent compositions.
专利号:US-4879389-A 优先权日:1986-06-25 标题:Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds 发明人:ACHIWA KAZUO 权利人:ACHIWA KAZUO 摘要:New chiral phosphinopyrrolidine compounds of the general formula: (I) or (I') wherein R1 is a hydrogen atom, -COR, -COOR, -CONHR or -SO2-R where R is an alkyl or aryl group, R2 and R3 each represents independently an aryl group which may have a substituent or substituents, and R4 and R5 each represents independently an aliphatic or cycloaliphatic hydrocarbyl group which may have a substituent or substituents, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.
专利号:US-9181237-B2 优先权日:2013-10-04 标 题 :Substituted berbines and their synthesis 发明人:GROTE CHRISTOPHER W 权利人:MALLINCKRODT LLC 摘要:The present invention provides substituted berbines, processes for the synthesis of substituted berbine compounds, as well as intermediates used in the synthesis of substituted berbine compounds. Also provided are methods for using the substituted berbines to inhibit cancer cell growth.
专利号:US-8835656-B2 优先权日:2012-01-30 标 题 :Linker and support for solid phase synthesis of nucleic acid 发明人:TSUKAMOTO MASAKI; SUZUKI NORITAKA; HAYAKAWA YOSHIHIRO; MAETA ERI; MORI KENJIRO; MINOMI KENJIRO 权利人:NITTO DENKO CORP; UNIV NAGOYA NAT UNIV CORP 摘要:The invention provides a universal linker capable of synthesizing nucleic acid having a hydroxy group at the 3′ terminal, a universal support carrying the linker, and a synthesis method of nucleic acid using the universal support. The linker contains a compound represented by the formula n nwherein each symbol is as defined in the specification.