CAS: 60280-45-7; Boc-Met(O2)-Oh

相似化合物

163437-14-7 7314-32-1 1247791-23-6

上下游产品

CAS号1070-19-5 Carbonazidic ac... | CAS号7314-32-1 L-蛋氨酸砜 | CAS号2488-15-5 B°C-L-蛋氨酸 | CAS号148927-60-0 L-368,899 hydro...

📜Boc-L-蛋氨酸置于oxone体系中,用 甲醇 作为反应溶剂,化学反应 2.0H,反应生成 丁氧羰基-甲硫氨酸(O2)-Oh
参考文献:代谢组学指导的铜绿微囊藻培养物中微精蛋白肽的发现
标题:代谢组学指导的铜绿微囊藻培养物中微精蛋白肽的发现
摘要:我们报告的实验室培养的菌株的基于质谱的代谢组学研究铜绿微囊藻(utex Lb2385),这导致了5种肽(的发现1-5)属于microginin类线性cyanopeptides的.这些肽的结构和构型是通过光谱分析和化学衍生法确定的.所述microginin肽本文描述了含有所述第一报道衍生物ñ甲基甲硫氨酸(1,5)和ñ甲基蛋氨酸亚砜(2-4).两个三肽microginin类似物(4,5所鉴定的)代表该肽家族的最小成员.还研究了它们对血管紧张素转化酶(ace)的抑制活性.microginin 527(4)是该组中最有效的,Ic 50为31μm.
DOI:10.1021/acs.Jnatprod.7B00829

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-6359144-B1
优先权日:1997-02-04
标 题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
发明人：OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; BLONDELLE SYLVIE E; SCHONER CHRISTA C; HOUGHTEN RICHARD A
权利人:LION BIOSCIENCE AG
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.

专利号:EP-0614894-A1
优先权日:1993-03-12
标 题 :Process for the synthesis of substituted amide derivatives of piperazinylcamphorsulfonyl oxytocin antagonists