CAS: 585543-15-3; 6-(5-(Cyclopropylcarbamoyl)-3-Fluoro-2-Methylphenyl)-N-Neopentylnicotinamide

📜3-氟-4-甲基-5-碘苯甲酸置于(1,1'-Bis(Diphenylphosphino)Ferrocene)Palladium(II) Dichloride,四(三苯基膦)钯,氯化亚砜,Potassium Acetate,碳酸氢钠,Sodium Carbonate体系中,用 二氯甲烷,N,N-二甲基甲酰胺,异丙醇 作为反应溶剂,化学反应 29.0H,反应生成 罗斯匹莫
参考文献:Ep3357916
标题:Ep3357916

专利信息

专利号:US-9295731-B2
优先权日:2013-04-01
标题 :Cleavable drug conjugates, compositions thereof and methods of use
发明人：NGUYEN MARK QUANG
权利人:NGUYEN MARK QUANG
摘要:Base-labile crosslinkers, base-labile conjugates comprising such crosslinkers, methods of their synthesis and use are disclosed.

专利号:WO-2013078523-A1
优先权日:2011-11-29
标题:Heterocyclic n-glycinyl-n-acyl hydrazone compounds, synthesis method, pharmaceutical compositions and treatment method
发明人：MANSSOUR FRAGA CARLOS ALBERTO; DE LACERDA BARREIRO ELIEZER DE JESUS; BARBOSA LACERDA RENATA; PALHARES DE MIRANDA ANA LUISA; LOUBACK DA SILVA LEANDRO; FREITAS DE LIMA CLEVERTON KLEITON
权利人:UNIV RIO DE JANEIRO
摘要:New heterocyclic derivatives are described, having the N-glycinyl-N-acyl hydrazone subunit and acting as analgesic and anti-inflammatory agents with in vitro e in vivo inhibiting activity on pro-inflammatory TNF-α cytokine, and useful therefore for the treatment of pain and acute and chronic inflammation, including: relieving hyperalgesia associated with acute and chronic inflammation in mammals, preferably humans. Also described are pharmaceutical compositions containing these compounds and methods for preparing the same.

专利号:CN-110950848-B
优先权日:2018-09-27
标题 :Synthesis and Application of New Aminopyrazole Derivatives