溴甲烷,Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于氯仿体系中,化学反应生成 溴丙胺太林 参考文献:Quaternary Ammonium Salts Of Dialkyl Aminoalkyl Xanthene-9-Carboxylates And The Production Thereof 标题:Quaternary Ammonium Salts Of Dialkyl Aminoalkyl Xanthene-9-Carboxylates And The Production Thereof
专利号:US-9751877-B2 优先权日:2012-09-21 标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders 发明人:PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT 权利人:PFIZER 摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
专利号:US-4151187-A 优先权日:1977-02-22 标题:Intermediates for prostaglandin synthesis 发明人:COLLINS PAUL W; PAPPO RAPHAEL 权利人:SEARLE G D & 摘要:Compounds of the formula ##STR1## wherein R is phenyl cyclohexyl or lower alkyl containing 1-6 carbon atoms; R' is hydrogen or methyl; R'' is alkenyl or alkynyl having 3-5 carbon atoms; R' is hydrogen, tetrahydrofuran-2-yl tetrahydropyran-2-yl or trialkylsilyl wherein the alkyl contains 1-4 carbon atoms. Compounds of the present invention are useful in synthesizing prostaglandin like molecules which are active anti-secretory agents.
专利号:EP-1930323-A1 优先权日:2004-03-11 标 题:Biphenyl compounds useful in the synthesis of muscarinic receptor antagonists
专利号:EP-1930323-B1 优先权日:2004-03-11 标 题:Biphenyl compounds useful in the synthesis of muscarinic receptor antagonists
专利号:US-2023047961-A1 优先权日:2019-12-03 标 题 :The cholesterol-syntesis intermediates for treatment demyelinating disorders 发明人:BERGHOFF STEFAN; SAHER GESINE 权利人:MAX PLANCK GESELLSCHAFT 摘要:The present invention relates to a cholesterol-synthesis intermediate as pharmaceutically active agent and/or pharmaceutical composition comprising the cholesterol-synthesis intermediate optionally together with one or two further pharmaceutically active agent(s) for use in the prophylaxis and/or treatment of demyelinating disorders/diseases, in particular multiple sclerosis.
专利号:US-9550795-B2 优先权日:2011-08-31 标 题:Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds 发明人:BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; HELAL CHRISTOPHER JOHN; O'NEILL BRIAN THOMAS 权利人:BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; HELAL CHRISTOPHER JOHN; O'NEILL BRIAN THOMAS; PFIZER 摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
1: Gyldenløve M, Thyssen JP. [Propantheline bromide is effective against dog drooling]. Ugeskr Laeger. 2015 Dec 21;177(52). pii: V67934. Danish. doi: 10.1016/j.talanta.2014.08.068. Epub 2014 Sep 6. doi: 10.1016/j.saa.2012.10.070. Epub 2012 Nov 7. German. doi: 10.1023/A:1016336005391. 14: Rigby GV, Vose CW, Haskins NJ, Allan EF, Harrison IR, Shelton JR, Brownsill RD, Perkins RM, Ford GC, Hawkins AJ, et al. Propantheline bromide plasma level, urinary excretion and pharmacological data in a comparison of the bioavailability of three oral formulations of Pro-Banthine. Eur J Drug Metab Pharmacokinet. 1983 Jul-Sep;8(3):219-24.
合成参考文献
参考文献:10.1007/s00535-005-1687-8 摘要:Hojo M, Miwa H, Yokoyama T, Ohkusa T, Nagahara A, Kawabe M, Asaoka D, Izumi Y, Sato N. Treatment of functional dyspepsia with antianxiety or antidepressive agents: systematic review. J Gastroenterol. 2005 Nov;40(11):1036–42. doi: 10.1007/s00535-005-1687-8.